Besifloxacin belongs to a class of medications called quinolone antibiotics. It is used to treat certain types of Eye Infections (called bacterial conjunctivitis or "pink eye") that are caused by bacteria. Besivance (Besifloxacine-eent) works by killing the bacteria that cause these infections.

Your doctor may have suggested Besivance (Besifloxacine-eent) for conditions other than those listed in these drug information articles. As well, some forms of Besivance (Besifloxacine-eent) may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given Besivance (Besifloxacine-eent), speak to your doctor. Do not stop using Besivance (Besifloxacine-eent) without consulting your doctor.

Do not give Besivance (Besifloxacine-eent) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Besivance (Besifloxacine-eent) if their doctor has not prescribed it.

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The usual recommended dose for adults and children over 1 year of age is one drop in each affected eye 3 times a day for 7 days.

Before using the eye drops, wash your hands thoroughly. Follow your doctor's or pharmacist's instructions on how to use the eye drops. Before each use, invert the closed bottle and shake once. Do not allow the eye dropper to touch your eyelids, surrounding areas, or any surface. This could contaminate the dropper and lead to an eye infection. Keep the bottle tightly closed when you are not using it.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Besivance (Besifloxacine-eent) exactly as prescribed by your doctor. If you miss a dose, instill it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double a dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Besivance (Besifloxacine-eent) at room temperature, protect it from light, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Besivance (Besifloxacine-eent). If you are concerned about side effects, discuss the risks and benefits of Besivance (Besifloxacine-eent) with your doctor.

The following side effects have been reported by at least 1% of people taking Besivance (Besifloxacine-eent). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• blurred vision
• eye discharge
• eye irritation
• eye itching
• eye pain

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Besivance (Besifloxacine-eent).

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Each mL contains 6 mg besifloxacin. Nonmedicinal ingredients: benzalkonium chloride 0.01% as a preservative, polycarbophil, mannitol, poloxamer 407, sodium chloride, edetate disodium dihydrate, sodium hydroxide, and water for injection.

Besifloxacin eye drops should not be used by anyone who:

• is allergic to besifloxacin or to any of the ingredients of the medication
• is allergic to other fluoroquinolones (e.g., ciprofloxacin, gemifloxacin, levofloxacin)

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Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Besivance (Besifloxacine-eent).

Appropriate use of eye drops: When using Besivance (Besifloxacine-eent), avoid allowing the tip of the eye dropper to contact the eye, eyelid, fingers, or any other surface. If the tip touches these surfaces, it can become contaminated with bacteria and may worsen your condition. Do not share this product with anyone as it may spread the infection.

Contact lenses: If you wear soft contact lenses, remove them while you are being treated for bacterial conjunctivitis.

Eye infections: If eye irritation occurs or if the eye infection worsens or has not started to improve in 2 days, you should call your doctor immediately. To minimize the risk of spreading the infection to others, wash your hands frequently and avoid sharing towels, pillowcases, face cloths, or soap with anyone who is infected.

Overgrowth of organisms: Prolonged use of Besivance (Besifloxacine-eent) may cause an overgrowth of organisms that Besivance (Besifloxacine-eent) does not effectively kill. If your symptoms worsen or do not improve, call your doctor as soon as possible.

Pregnancy: Besivance (Besifloxacine-eent) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using Besivance (Besifloxacine-eent), contact your doctor immediately.

Breast-feeding: It is not known if besifloxacin passes into breast milk. If you are a breast-feeding mother and are taking Besivance (Besifloxacine-eent), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Besivance (Besifloxacine-eent) have not been established for children under 1 year of age.

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