Ipratropium belongs to the group of medications called bronchodilators. It is used to treat COPD (Chronic Obstructive Pulmonary Disease) (COPD), including chronic Bronchitis and emphysema.

It is also used along with other medications to treat Asthma attacks.

Ipratropium works by opening the air passages, making breathing easier. This solution is given with the help of compressed air or nebulizers.

Ipratropium Polyneb (Ipratropium-inh) may be available under multiple brand names and/or in several different forms. Any specific brand name of Ipratropium Polyneb (Ipratropium-inh) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Ipratropium Polyneb (Ipratropium-inh) may not be used for all of the conditions discussed here.

Your doctor may have suggested Ipratropium Polyneb (Ipratropium-inh) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Ipratropium Polyneb (Ipratropium-inh), speak to your doctor. Do not stop using Ipratropium Polyneb (Ipratropium-inh) without consulting your doctor.

Do not give Ipratropium Polyneb (Ipratropium-inh) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Ipratropium Polyneb (Ipratropium-inh) if their doctor has not prescribed it.

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The recommended adult dose of ipratropium inhalation solution is 250 µg to 500 µg. For children (5 to 12 years of age), the recommended dose is 125 µg to 250 µg. The dose may be repeated every 4 to 6 hours as needed.

For regular treatment of breathing difficulties caused by chronic bronchitis or emphysema, the recommended adult dose is 500 µg 3 to 4 times a day. If less than 2 mL of solution is to be nebulized, a sterile, preservative-free saline or another suitable nebulizer solution should be used to make up the total volume to between 2 mL and 5 mL.

Your doctor or pharmacist should tell you how to use Ipratropium Polyneb (Ipratropium-inh) properly. Also, follow the instructions found with the medication and with your nebulizer for proper treatment, care, maintenance, and equipment cleaning procedures. It is very important to adjust the face mask, if required, to prevent the mist from getting into your eyes.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important that Ipratropium Polyneb (Ipratropium-inh) be used exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Ipratropium Polyneb (Ipratropium-inh) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Ipratropium Polyneb (Ipratropium-inh). If you are concerned about side effects, discuss the risks and benefits of Ipratropium Polyneb (Ipratropium-inh) with your doctor.

The following side effects have been reported by at least 1% of people taking Ipratropium Polyneb (Ipratropium-inh). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Constipation
• cough
• Diarrhea
• Dry Mouth
• dizziness
• headache
• hoarseness
• nausea
• nervousness
• throat irritation
• trembling
• unpleasant taste
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• difficulty swallowing
• difficulty or pain when urinating
• fast or irregular heart beat
• blurred vision or eye pain
• skin rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

• symptoms of a Anaphylaxis (severe allergic reaction) (e.g., sudden wheezing, chest pain or chest tightness; Hives; swelling of the eyelids, face, tongue or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Ipratropium Polyneb (Ipratropium-inh).

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inhalation solution
Each mL of clear, colourless solution contains ipratropium bromide 125 µg.

1 mL Polyneb
Each mL of clear, colourless solution contains ipratropium bromide 250 µg in isotonic solution, presented in a plastic single use vial.

2 mL Polyneb
Each mL of clear, colourless solution contains ipratropium bromide 250 µg in isotonic solution, presented in a plastic single use vial.

Ipratropium inhalation solution should not be used by anyone with an allergy or sensitivity to ipratropium, to atropine-like medications in general, or to any of the ingredients of the medication.

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There may be an interaction between ipratropium inhalation solution and any of the following:

• anticholinergic medications (e.g., tiotropium, Benztropine, Diphenhydramine)
• beta-adrenergic medications (e.g., salbutamol, salmeterol)
• potassium chloride tablets

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ipratropium Polyneb (Ipratropium-inh).

Allergy: In rare cases, immediate allergic reactions may occur after using ipratropium inhalation solution, causing hives, swelling around the throat and tongue, rash, and worsening of breathing problems. If this occurs, get emergency medical help at once.

Asthma attack: Do not use ipratropium alone for the relief of an asthma attack since Ipratropium Polyneb (Ipratropium-inh) works slower than other types of medications used for asthma attacks. If it is used for an asthma attack, it should be used together with other medications (e.g., salbutamol) that help open up the airways quickly.

Cystic Fibrosis: If you have cystic fibrosis, you may be more likely to experience certain side effects such as constipation. Talk to your doctor about how Ipratropium Polyneb (Ipratropium-inh) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ipratropium Polyneb (Ipratropium-inh), and whether any special monitoring is needed.

Eye concerns: Make sure the nebulizer mask fits the user's face properly and that nebulized solution does not escape into the eyes. There have been rare reports of eye complications (e.g., tearing, increased eye pressure, Glaucoma, and eye pain) when Ipratropium Polyneb (Ipratropium-inh) has been released into the eyes.

If you have glaucoma, talk to your doctor about how Ipratropium Polyneb (Ipratropium-inh) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ipratropium Polyneb (Ipratropium-inh), and whether any special monitoring is needed.

Mixing with other medications: Do not mix ipratropium solution with preservatives (i.e., from the 20 mL multidose bottle) and sodium cromoglycate, as this produces a cloudy solution caused by an interaction between the preservatives and the sodium cromoglycate. If sodium cromoglycate needs to be used, use ipratropium solution without preservatives (the unit dose vials).

Preservatives: Ipratropium solution in the 20 mL multidose bottle contains preservatives (benzalkonium chloride, disodium ethylene diamine tetraacetic acid (EDTA) disodium). It has been reported that these preservatives may cause a worsening of breathing in some patients with very sensitive airways.

The unit dose vials do not contain preservatives.

Urination problems: If you have a medical condition (e.g., prostate problems, urinary retention, or obstruction) that affects your ability to urinate, discuss with your doctor how Ipratropium Polyneb (Ipratropium-inh) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ipratropium Polyneb (Ipratropium-inh), and whether any special monitoring is needed.

Pregnancy: The safety of using ipratropium during pregnancy has not been established. Ipratropium Polyneb (Ipratropium-inh) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Ipratropium Polyneb (Ipratropium-inh), contact your doctor.

Breast-feeding: It is not known if Ipratropium Polyneb (Ipratropium-inh) passes into breast milk. If you are a breast-feeding mother and are using ipratropium inhalation solution, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The efficacy and safety of Ipratropium Polyneb (Ipratropium-inh) have not been established for children under 5 years of age.

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