This combination product contains two medications: betamethasone and Clotrimazole. It is used to treat itchy, inflamed skin rashes caused by certain types of fungus (e.g., Athlete's Foot, Tinea Cruris (Jock Itch), ringworm). Betamethasone belongs to the group of medications called corticosteroids and it works by decreasing inflammation. Clotrimazole belongs to the group of medications called antifungals and it works by killing certain types of fungus.

Once treatment is started, itching and redness are usually relieved within 3 to 5 days. If relief does not occur after 1 week of use for jock itch or ringworm, contact your doctor. If relief does not occur after 2 weeks of use for athlete's foot, contact your doctor.

Lotriderm may be available under multiple brand names and/or in several different forms. Any specific brand name of Lotriderm may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Lotriderm may not be used for all of the conditions discussed here.

Your doctor may have suggested Lotriderm for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Lotriderm, speak to your doctor. Do not stop using Lotriderm without consulting your doctor.

Do not give Lotriderm to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Lotriderm if their doctor has not prescribed it.

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Apply a thin film of cream to completely cover the affected and surrounding skin areas twice daily, in the morning and at night or as directed by your doctor. The cream is usually used for a period of 2 to 4 weeks depending on the condition being treated. Using the cream for more than 4 weeks is not recommended.

This cream should not be covered with bandages or other coverings after application. Do not use Lotriderm in or near the eyes.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one above, do not change the way that you are using the medication without consulting your doctor.

It is important to use Lotriderm exactly as prescribed by your doctor. If you miss a dose, apply it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Lotriderm at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses Lotriderm. If you are concerned about side effects, discuss the risks and benefits of Lotriderm with your doctor.

The following side effects have been reported by at least 1% of people using Lotriderm. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Acne outbreaks with skin redness
• blistering, stinging, itching, peeling, redness, swelling, or other signs of skin irritation not present before use of Lotriderm
• excessive hair growth
• numbness of the hands and feet
• patches of lighter skin tone
• skin rash
• skin redness around the mouth

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• Hives
• reddish purple lines on the skin
• skin infection
• stretch marks
• thinning of the skin or easy bruising
• tingling or pins and needles sensation on the skin

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Lotriderm.

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Lotriderm

Each 1 g of white-to-off-white cream contains 10 mg of clotrimazole USP and 0.64 mg of betamethasone dipropionate, USP, equivalent to 0.5 mg (0.05%) of betamethasone USP, in a hydrophilic emollient cream. Nonmedicinal ingredients: cetostearyl alcohol, macrogol cetostearyl ether, purified water, liquid paraffin, white soft paraffin, alcohol, propylene glycol, sodium dihydrogen phosphate dihydrate, and phosphoric acid; benzyl alcohol as preservative and sodium hydroxide to adjust pH.

Taro-Clotrimazole/Betamethasone dipropionate

Each 1 g of smooth white cream contains 10 mg of clotrimazole USP and 0.64 mg of betamethasone dipropionate, USP, equivalent to 0.5 mg (0.05%) of betamethasone USP, in a hydrophilic emollient cream. Nonmedicinal ingredients: purified water, cetostearyl alcohol, white petrolatum, mineral oil, cetomacrogol 1000, phosphoric acid, monobasic sodium phosphate, propylene glycol, benzyl alcohol as preservative and sodium hydroxide to adjust the pH.

Do not use betamethasone dipropionate - clotrimazole if you:

• are allergic to betamethasone, clotrimazole, or any ingredients of Lotriderm
• are allergic to other corticosteroids (e.g., Hydrocortisone, clobetasol) or imidazoles (e.g., miconazole)
• have untreated bacterial infections of the skin
• have untreated Tuberculosis of the skin
• have viral diseases of the skin, including:
• vaccinia
• varicella (Chickenpox)
• herpes simplex

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There may be an interaction between betamethasone - clotrimazole and any of the following:

• Aldesleukin
• Sirolimus
• Tacrolimus
• other topical medications containing corticosteroids
• topical medications that have irritating effects

If you are using any medications that fit this description, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Lotriderm. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or illegal drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Lotriderm.

Inform all health professionals involved in your care that you have been using corticosteroids.

Eyes: Do not use Lotriderm in or around the eyes. Wash your hands and do not touch your eyes after applying Lotriderm. Absorption of Lotriderm around the eyes can increase the risks for developing Cataracts or Glaucoma. If you experience blurred vision or any other changes to your eyesight, contact your doctor as soon as possible.

Medical conditions: If you have stasis dermatitis and other skin conditions with reduced blood circulation, discuss with your doctor how Lotriderm may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lotriderm, and whether any special monitoring is needed.

Overuse of medication: Side effects caused by absorption into the blood stream are less common with betamethasone dipropionate - clotrimazole than some other medications containing corticosteroids. Long-term use of Lotriderm over large areas of the body or under dressings that don't breathe could lead to the absorption of betamethasone into the body's blood circulation, resulting in changes in hormone levels and other side effects. Discuss any concerns you may have with your doctor.

Thinning of skin: Prolonged use of topical (applied to the skin) corticosteroid products may produce thinning of the skin and tissues under it. If you notice this, call your doctor.

Pregnancy: Lotriderm should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Lotriderm, contact your doctor immediately. Topical medications that contain corticosteroids should not be used by pregnant woman in large amounts or for prolonged periods of time.

Breast-feeding: It is not known if Lotriderm passes into breast milk. If you are a breast-feeding mother and are using Lotriderm, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Lotriderm have not been established for children under the age of 12 years. The use of topical corticosteroids such as betamethasone by children should be limited to the least amount that will give good results. Chronic corticosteroid therapy may interfere with growth and physical development of children.

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