NI Odan (Niacin) extended release belongs to the family of medications known as lipid metabolism regulators. It is used to treat High Cholesterol. It is believed to work by decreasing the production of cholesterol in the body. It helps to lower total cholesterol, LDL-cholesterol (bad cholesterol) and triglycerides, and increase HDL-cholesterol (good cholesterol).

NI Odan (Niacin) should be used in combination with an appropriate diet and exercise program to reduce cholesterol. It is not intended to be a substitute for healthy eating and exercise.

NI Odan (Niacin) may be available under multiple brand names and/or in several different forms. Any specific brand name of NI Odan (Niacin) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of NI Odan (Niacin) may not be used for all of the conditions discussed here.

Your doctor may have suggested NI Odan (Niacin) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking NI Odan (Niacin), speak to your doctor. Do not stop taking NI Odan (Niacin) without consulting your doctor.

Do not give NI Odan (Niacin) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take NI Odan (Niacin) if their doctor has not prescribed it.

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The usual recommended starting dose of NI Odan (Niacin) extended release is 500 mg at bedtime, after a low-fat snack. The dose is gradually increased every 4 weeks to a maximum dose of 2,000 mg at bedtime. NI Odan (Niacin) extended release should be used in combination with an appropriate exercise program to reduce cholesterol and it is not intended as a substitute for such a program.

NI Odan (Niacin) extended release tablets should be swallowed whole and not crushed or chewed.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take NI Odan (Niacin) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you miss taking NI Odan (Niacin) for 7 days or more, contact your doctor for instructions on how to restart taking it.

Store NI Odan (Niacin) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes NI Odan (Niacin). If you are concerned about side effects, discuss the risks and benefits of NI Odan (Niacin) with your doctor.

The following side effects have been reported by at least 1% of people taking NI Odan (Niacin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Diarrhea
• dizziness
• drowsiness
• Dry Mouth
• flu-like symptoms (e.g., Fever, chills, sweating, muscle aches, tiredness)
• fluid retention (swelling of the hands, feet, or ankles)
• flushing (warmth, redness, itching, or tingling) of the face, neck, chest, and back
• headache
• heartburn
• increased cough
• nausea
• rapid or pounding heartbeat
• rash
• ringing in the ears
• sweating
• tiredness
• vomiting
• weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• fainting
• joint pain
• muscle pains or weakness
• severe headache (migraine)

• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)

• signs of liver problems (e.g., yellow eyes or skin, abdominal pain, dark urine or pale stools, nausea, vomiting)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• chest pain
• signs of a serious allergic reaction (swelling of the face, tongue, or throat; Hives; difficulty breathing)
• symptoms of bleeding in the stomach or intestines (dark, tarry stools; blood coming from rectum; vomiting blood or material that looks like coffee grounds; fast heartbeat; weakness or fainting)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking NI Odan (Niacin).

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Each white, caplet-shaped, unscored, time-release (extended-release) tablet, engraved "N-500" on one side, contains 500 mg of NI Odan (Niacin) (nicotinic acid). Nonmedicinal ingredients: methylcellulose, povidone, and stearic acid (plant source). This product does not contain cornstarch, gluten, lactose, sugar, yeast, soy, animal by-products, or artificial colours, flavours, or preservatives.

Do not take NI Odan (Niacin) if you:

• are allergic to NI Odan (Niacin) or any ingredients of the medication
• have active peptic (stomach or intestine) ulcer disease
• have bleeding
• have severe or unexplained liver or kidney problems or a history of jaundice (yellow skin)

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There may be an interaction between NI Odan (Niacin) extended release tablets and any of the following:

• acetylsalicylic acid (ASA)
• alcohol
• bile acid sequestrants (drugs that prevent cholesterol reabsorption by the body; Cholestyramine, Colestipol)
• certain blood pressure medications (e.g., Metoprolol, Propranolol, Verapamil, Diltiazem)
• diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Nateglinide, Rosiglitazone)
• nitrates (e.g., Nitroglycerin)
• "statin" cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• vitamins or nutritional supplements containing NI Odan (Niacin), nicotinic acid, or nicotinamide
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with NI Odan (Niacin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use NI Odan (Niacin).

Bleeding: NI Odan (Niacin) may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor may order routine blood tests to make sure potential problems are caught early.

Diabetes: People with diabetes may experience higher fasting blood sugar levels. If you have diabetes, your doctor may ask you to monitor your blood sugar more frequently and report any changes in your usual blood sugar patterns to your doctor. Your doctor may need to adjust the doses of your diabetes medications.

Fluid retention: NI Odan (Niacin) may cause fluid retention and swelling, possibly worsening high blood pressure, Congestive Heart Failure, or decreased heart function. If you have these conditions, discuss with your doctor how NI Odan (Niacin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of NI Odan (Niacin), and whether any special monitoring is needed.

If you develop shortness of breath; fatigue; excessive weight gain; chest pain; or swelling of the legs, feet, or ankles while taking NI Odan (Niacin), consult your doctor immediately.

Flushing: Some people taking NI Odan (Niacin) extended release may experience flushing, usually at the start of treatment or when the dose is increased. The flushing usually occurs during the first 8 weeks of treatment and will become milder and less frequent as treatment continues. Flushing usually occurs within 2 to 4 hours after taking a dose and may last a few hours.

Taking the medication at bedtime with a low-fat snack will help you deal with flushing by making it more likely to happen while you are asleep. If flushing wakes you up at night, get up slowly, especially if you are feeling faint or dizzy or if you are taking blood pressure medications.

Avoid alcohol, spicy foods, or hot drinks around the time you take NI Odan (Niacin) extended release, as these may increase flushing. If flushing is bothersome, your doctor may recommend that you take acetylsalicylic acid (Asa), if this is appropriate for you, up to 30 minutes before taking NI Odan (Niacin) extended release.

Gout: NI Odan (Niacin) may cause increased levels of uric acid in the blood, causing flare-ups of gout. If you have gout, discuss with your doctor how NI Odan (Niacin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of NI Odan (Niacin), and whether any special monitoring is needed. Report any joint pain, joint swelling, or warmth to your doctor immediately.

Heart problems: If you have unstable Angina or other heart conditions, discuss with your doctor how NI Odan (Niacin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of NI Odan (Niacin), and whether any special monitoring is needed.

Kidney function: Kidney Disease and reduced kidney function may cause NI Odan (Niacin) to build up in the body and cause an increase in side effects. If you have kidney disease, discuss with your doctor how NI Odan (Niacin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of NI Odan (Niacin), and whether any special monitoring is needed.

Liver disease: On rare occasions, liver damage has occurred in people taking NI Odan (Niacin). If you have liver disease or a large alcohol intake you should be closely monitored by your doctor while taking NI Odan (Niacin) extended release. People with severe or unexplained liver disease should not take NI Odan (Niacin) extended release.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Restarting the medication: If you need to restart the medication after you have not taken it for a long period of time, check with your doctor first. You may need to restart treatment at a lower dose and gradually increase the dose over time.

Serious warnings and precautions: If you were previously taking another NI Odan (Niacin) tablet, do not start extended-release NI Odan (Niacin) at the same dose. You must start with a lower dose of extended release NI Odan (Niacin) and gradually increase your dose as directed by your doctor.

Do not substitute one NI Odan (Niacin) product for another; improper substitution can cause severe liver disorders.

Stomach problems: NI Odan (Niacin) may cause stomach problems such as ulcers or bleeding. If you have stomach problems, discuss with your doctor how NI Odan (Niacin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of NI Odan (Niacin), and whether any special monitoring is needed.

Call your doctor immediately if you notice signs such as stomach or abdominal pain, black tarry stools, or vomiting blood. Using acetylsalicylic (ASA) to reduce flushing caused by NI Odan (Niacin) may increase the risk of stomach problems.

Pregnancy: NI Odan (Niacin) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking NI Odan (Niacin), contact your doctor immediately.

Breast-feeding: NI Odan (Niacin) passes into breast milk. If you are a breast-feeding mother and are taking NI Odan (Niacin) extended release, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using NI Odan (Niacin) have not been established for children.

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