Oleptro (Trazodone) belongs to the class of medications called antidepressants. It is used to treat symptoms of Depression. It works by affecting the balance of chemicals in the brain that are associated with depression. Oleptro (Trazodone) is thought to work by increasing the levels of serotonin in the brain. It may take several weeks before the full benefit of Oleptro (Trazodone) is seen.

Your doctor may have suggested Oleptro (Trazodone) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Oleptro (Trazodone), speak to your doctor. Do not stop taking Oleptro (Trazodone) without consulting your doctor.

Do not give Oleptro (Trazodone) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Oleptro (Trazodone) if their doctor has not prescribed it.

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The usual recommended adult dose of Oleptro (Trazodone) extended-release is 150 mg taken once daily in the evening before bed. After this, the dose may be gradually increased to a maximum of 375 mg daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Oleptro (Trazodone) extended-release caplets should be swallowed whole or broken in half along the score line. Oleptro (Trazodone) is controlled-release and is meant to work over a 24-hour period. It should not be chewed or crushed. This will cause the medication to be released into the body at one time.

Oleptro (Trazodone) should be taken at the same time every day, in the evening before bed, and on an empty stomach.

It is important to take Oleptro (Trazodone) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a dose in the morning to make up for a missed dose the night before. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Oleptro (Trazodone) at room temperature, protect it from light, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Oleptro (Trazodone). If you are concerned about side effects, discuss the risks and benefits of Oleptro (Trazodone) with your doctor.

The following side effects have been reported by at least 1% of people taking Oleptro (Trazodone). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain or discomfort
• back pain
• Constipation
• decreased appetite
• decreased sense of taste
• decreased sexual desire or ability
• Diarrhea
• dizziness or lightheadedness
• drowsiness
• Dry Mouth
• fatigue
• headache
• joint pain or swelling
• muscle ache or stiffness
• nausea
• rash
• tremor

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• agitation
• blurred vision
• breast enlargement (in men)
• breast leakage of milk (in women, even if not pregnant)
• changes in menstrual cycle
• confusion
• decreased hearing
• dizziness when rising from sitting or lying position
• fast or pounding heartbeat
• Fever, sore throat, general feeling of being unwell
• migraine
• new or worsened emotional or behavioural problems
• pounding heartbeat
• problems with balance
• reduced sexual function
• ringing in the ears
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
• signs of a urinary tract infection such as difficult or painful urination, or blood in the urine
• swelling in the feet or legs
• symptoms of low sodium in the blood (e.g., tiredness, weakness, or confusion combined with achy uncoordinated muscles)
• symptoms of mania (e.g., elevated or irritable mood, reduced need for sleep, racing thoughts)
• uncontrollable movements of the hands or face
• vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

• painful, prolonged, or inappropriate erection of the penis lasting more than 4 hours
• seizures
• symptoms of a serious allergic reaction (swelling of the face or throat, difficulty breathing, wheezing, or itchy skin rash)
• symptoms of serotonin syndrome (e.g., confusion, fast heartbeat, hallucinations, restlessness, shaking, shivering, sudden jerking of muscles, sweating)
• thoughts of self-harm or suicide

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Oleptro (Trazodone).

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150 mg
Each yellowish-beige caplet, printed with a logo on one side and scored on both sides, contains 150 mg of Oleptro (Trazodone). Nonmedicinal ingredients: hydroxypropyl distarch phosphate (Contramid®), hypromellose, sodium stearyl fumarate, colloidal silicon dioxide, iron oxide yellow (CI number 77492), iron oxide red (CI number 77491), talc, Polyethylene Glycol 3350, polyvinyl alcohol, titanium dioxide (CI number 77891), iron oxide black (CI number 77499), shellac glaze, ethanol, isopropyl alcohol, N-butyl alcohol, propylene glycol, and ammonium hydroxide.

300 mg
Each beige-orange caplet, printed with a logo on one side and scored on both sides contains 300 mg of Oleptro (Trazodone). Nonmedicinal ingredients: hydroxypropyl distarch phosphate (Contramid®), hypromellose, sodium stearyl fumarate, colloidal silicon dioxide, iron oxide yellow (CI number 77492), iron oxide red (CI number 77491), talc, polyethylene glycol 3350, polyvinyl alcohol, titanium dioxide (CI number 77891), iron oxide black (CI number 77499), shellac glaze, ethanol, isopropyl alcohol, N-butyl alcohol, propylene glycol, and ammonium hydroxide.

Do not take this mediction if you are allergic to Oleptro (Trazodone) or any ingredients of the medication.

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Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.

There may be an interaction between Oleptro (Trazodone) extended-release and any of the following:

• Abiraterone
• alcohol
• amphetamines (e.g., Dextroamphetamine, lisdexamphetamine)
• antiarrhythmic medications (e.g., Amiodarone, sotalol, quinidine, Flecainide)
• antiepileptic medications (e.g., Carbamazepine, Phenytoin, Valproic acid)
• antipsychotics (e.g., chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• azole antifungals (e.g., itraconazole, ketoconazole, posaconazole, Voriconazole)
• beta-blocker inhalers (e.g., salmeterol, formoterol)
• boceprevir
• Bromocriptine
• Buspirone
• Cabergoline
• Cobicistat
• conivaptan
• Cyclobenzaprine
• Dextromethorphan
• Deferasirox
• Diltiazem
• Domperidone
• droperidol
• Enzalutamide
• ergotamine-like medications (e.g., dihydroergoatime, ergotamine, methylergonovine)
• grapefruit juice
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Levomilnacipran
• Linagliptin
• Linezolid
• lithium
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• mefloquine
• methylene blue
• Metoclopramide
• mifepristone
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., Maprotiline, Moclobemide, Phenelzine, Selegiline, Tranylcypromine)
• nefazodone
• nicardipine
• opioid pain medications (e.g., Codeine, Morphine)
• Phenobarbital
• Primaquine
• primidone
• protein kinase inhbitors (e.g., Dasatinib, imatinib, Lapatinib, Pazopanib, Sunitinib)
• quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, moxifloxacin)
• quinidine
• quinine
• rifabutin
• rifampin
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, Venlafaxine)
• simeprevir
• St. John's wort
• tacrolimus
• telaprevir
• tetrabenzine
• tricyclic antidepressants (e.g., Amitriptyline, Desipramine, Trimipramine)
• "triptan" migraine medications (e.g., Sumatriptan, Zolmitriptan)
• Tryptophan
• Verapamil
• warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Oleptro (Trazodone). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Oleptro (Trazodone).

Abnormal bleeding: Other medications similar to Oleptro (Trazodone) have been known to cause abnormal bleeding, including bleeding in the stomach or intestines. If you have or have had a history of bleeding disorders, discuss with your doctor how Oleptro (Trazodone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Oleptro (Trazodone), and whether any special monitoring is needed.

Report any unusual bruising or bleeding to your doctor, especially if you are taking medications that affect blood clotting. These medications include acetylsalicylic acid (Asa), Clopidogrel, Dipyridamole, nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., Ibuprofen or Naproxen), other anticoagulant drugs (e.g., Warfarin), and certain antipsychotic and antidepressant medications.

Abnormal heart rhythms: Oleptro (Trazodone) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, droperidol, Pimozide, ciprofloxacin, moxifloxacin, Mefloquine, pentamidine, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Oleptro (Trazodone).

QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death. You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are a woman
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have Diabetes
• have had a Stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies

If you are at risk for heart rhythm problems, discuss with your doctor how Oleptro (Trazodone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Oleptro (Trazodone), and whether any special monitoring is needed.

Behaviour changes and suicidal thoughts: Oleptro (Trazodone), like other medications used to treat depression, may worsen symptoms of depression. People taking Oleptro (Trazodone) may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after starting Oleptro (Trazodone).

If you experience these side effects or notice them in a family member who is taking Oleptro (Trazodone), contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking Oleptro (Trazodone).

Dizziness: Oleptro (Trazodone) can cause severe dizziness, especially when rising from a sitting or lying position. People taking medications that can cause dizziness should rise slowly from sitting or lying down to reduce the possibility of severe dizziness or fainting.

Drowsiness/reduced alertness: Oleptro (Trazodone) may cause drowsiness or dizziness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how Oleptro (Trazodone) affects you.

Priapism: Oleptro (Trazodone) has been associated with prolonged or inappropriate erections (priapism) for a number of men taking Oleptro (Trazodone). If this occurs, stop taking the medication, and seek immediate medical attention.

Seizures: Seizures have been reported for a small number of people taking Oleptro (Trazodone). If you have a history of Epilepsy or medical conditions that increase the risk of seizures, discuss with your doctor how Oleptro (Trazodone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Oleptro (Trazodone), and whether any special monitoring is needed.

Serotonin syndrome: Rarely, severe, life-threatening reactions are possible when Oleptro (Trazodone) is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, which are other medications used to treat depression. This is called serotonin syndrome. These combinations should be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation. Coma and death are possible.

Stopping the medication: Stopping Oleptro (Trazodone) suddenly may lead to side effects such as agitation, anxiety, and sleep disturbances. If you are thinking of stopping the medication, check with your doctor first. Your doctor may want you to decrease the dose of the medication gradually when it is time to stop taking Oleptro (Trazodone).

Pregnancy: Oleptro (Trazodone) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Oleptro (Trazodone), contact your doctor immediately.

Breast-feeding: Oleptro (Trazodone) may pass into breast milk. If you are a breast-feeding mother and are taking Oleptro (Trazodone) extended-release, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Oleptro (Trazodone) have not been established for people less than 18 years of age.

Seniors: People over 65 years of age may require doses that are lower than those recommended here, to reduce the possibility and severity of side effects.

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