Progesterone belongs to the class of medications called progestins. Progesterone injection is used to treat amenorrhea (lack of menstrual periods) and abnormal bleeding from the vagina caused by changes in hormone levels. When used for amenorrhea, the effects are usually seen within 2 to 3 days of the last injection. When used for abnormal bleeding from the vagina, effects are usually seen within 6 days.

Your doctor may have suggested Progesterone for conditions other than those listed in these drug information articles. As well, some forms of Progesterone may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are using Progesterone, speak to your doctor. Do not stop using Progesterone without consulting your doctor.

Do not give Progesterone to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Progesterone if their doctor has not prescribed it.

Amenorrhea: The usual recommended dose is 5 to 10 mg injected into a muscle once daily for 6 to 8 days.

Abnormal bleeding from the vagina: The usual recommended dose is 5 to 10 mg injected into a muscle once daily for 6 days.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important Progesterone be given exactly as recommended by your doctor. If you miss an appointment to receive progesterone injection, contact your doctor as soon as possible to reschedule your appointment.

Store Progesterone at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Progesterone. If you are concerned about side effects, discuss the risks and benefits of Progesterone with your doctor.

The following side effects have been reported by at least 1% of people using Progesterone. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain or cramping Acne bloating or swelling of ankles or feet blood pressure increase (mild) breast pain or tenderness brown spots on exposed skin, possibly long-lasting dizziness drowsiness

headache (mild) hot flashes loss or gain of body, facial, or scalp hair loss of sexual desire mood changes nervousness swelling of face, ankles, or feet trouble sleeping unusual or rapid weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Depression
• skin rash
• symptoms of blood sugar problems (Dry Mouth, frequent urination, loss of appetite, or unusual thirst)
• unexpected changes in vaginal bleeding such as:
  • heavier vaginal bleeding between regular monthly periods
  • increased amounts of menstrual bleeding occurring at regular monthly periods
  • lighter vaginal bleeding between menstrual periods
  • stopping of menstrual periods
• unexpected or increased flow of breast milk

Stop taking the medication and seek immediate medical attention if any of the following occur:

• headache or migraine
• loss of or change in speech, coordination, or vision (including double vision)
• numbness of or pain in chest, arm, or leg
• unexplained shortness of breath

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Progesterone.

Each mL of injection contains progesterone 50 mg. Nonmedicinal ingredients: benzyl alcohol 10% (as a preservative) and sesame oil.