Vasotec IV (Enalapril) belongs to the class of medications called angiotensin converting enzyme (ACE) inhibitors. It is used to treat high blood pressure and Congestive Heart Failure.

Vasotec IV (Enalapril) works by relaxing blood vessels and by making the heart pump more efficiently. The injectable form is used to lower high blood pressure when the oral form cannot be used.

Vasotec IV (Enalapril) may be available under multiple brand names and/or in several different forms. Any specific brand name of Vasotec IV (Enalapril) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Vasotec IV (Enalapril) may not be used for all of the conditions discussed here.

Your doctor may have suggested Vasotec IV (Enalapril) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Vasotec IV (Enalapril), speak to your doctor. Do not stop using Vasotec IV (Enalapril) without consulting your doctor.

Do not give Vasotec IV (Enalapril) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Vasotec IV (Enalapril) if their doctor has not prescribed it.

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The recommended starting dose for high blood pressure is 2.5 mg to 5 mg taken once a day. The usual treatment dose ranges from 2.5 mg once daily to 20 mg twice daily, depending on the needs and circumstances of the person using the medication. The dose may need to be adjusted according to how well the kidneys are functioning and the effectiveness of the medication.

The starting dose for children less than 16 years of age is based on body weight and will be calculated by your child’s doctor.

The recommended starting dose to treat congestive heart failure is 2.5 mg taken once a day. The dose may be increased gradually to a maximum of 40 mg daily, depending on the effectiveness of the medication.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Vasotec IV (Enalapril) exactly as prescribed by your doctor. If you miss a dose, and it is within 6 hours of your regularly scheduled time, administer it as soon as possible and continue with your regular schedule. If more than 6 hours has passed, skip the missed dose and continue with your regular dosing schedule. Do not administer a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Vasotec IV (Enalapril) at room temperature, protect it from moisture and keep out of reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Vasotec IV (Enalapril). If you are concerned about side effects, discuss the risks and benefits of Vasotec IV (Enalapril) with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• cough (dry, persistent)
• Diarrhea
• fatigue
• headache
• loss of appetite
• nausea
• rash
• sore throat
• vomiting

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• chest pain
• dizziness, lightheadedness, or fainting (signs of Low Blood Pressure)
• flu-like symptoms (sudden lack of energy, Fever, cough, sore throat)
• shortness of breath
• signs of  liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of too much potassium in the body (e.g., confusion; irregular heartbeat; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath or difficulty breathing; weakness or heaviness of legs)
• symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heart beat, weakness

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of angioedema (e.g., swelling of face, mouth, hands, or feet)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Vasotec IV (Enalapril).

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Tablets
2.5 mg
Each white, oval-shaped, tablet engraved "MSD 14" on one side and scored on both sides contains 2.5 mg of Vasotec IV (Enalapril) maleate. Nonmedicinal ingredients: cornstarch, lactose, magnesium stearate, pregelatinized starch, and sodium bicarbonate. The splitting of VASOTEC tablets is not advised.

5 mg
Each white, rounded, triangle-shaped tablet engraved "MSD 712" on one side and scored on the other contains 5 mg of Vasotec IV (Enalapril) maleate. Nonmedicinal ingredients: cornstarch, lactose, magnesium stearate, pregelatinized starch, and sodium bicarbonate. The splitting of VASOTEC tablets is not advised.

10 mg
Each rust red, rounded, triangle-shaped tablet engraved "MSD 713" on one side and scored on the other contains 10 mg of Vasotec IV (Enalapril) maleate. Nonmedicinal ingredients: cornstarch, lactose, magnesium stearate, pregelatinized starch, red or yellow iron oxides, and sodium bicarbonate. The splitting of VASOTEC tablets is not advised.

20 mg
Each peach-coloured, rounded, triangle-shaped tablet engraved "MSD 714" on one side and scored on the other contains 20 mg of Vasotec IV (Enalapril) maleate. Nonmedicinal ingredients: cornstarch, lactose, magnesium stearate, pregelatinized starch, red and/or yellow iron oxides, and sodium bicarbonate. The splitting of VASOTEC tablets is not advised.

Vasotec I.V.
Each mL of clear, colourless solution contains 1.25 mg of enalaprilat (anhydrous equivalent), 6.2 mg of sodium chloride to adjust tonicity, sodium hydroxide to adjust pH (to approximately 7.0), water for injection, with 9 mg of benzyl alcohol as preservative.

Do not take Vasotec IV (Enalapril) if you:

• are allergic to Vasotec IV (Enalapril) or any ingredients of the medication
• are pregnant or planning to get pregnant
• have been diagnosed with hereditary angioedema
• have had angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any other ACE inhibitors (e.g., Captopril, Vasotec IV (Enalapril), Ramipril)
• have Diabetes or Kidney Disease and are taking Aliskiren

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There may be an interaction between Vasotec IV (Enalapril) and any of the following:

• acetylsalicylic acid (Asa)
• Aldesleukin
• aliskiren
• Allopurinol
• alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• alpha agonists (e.g., Clonidine, methyldopa)
• amifostine
• Amiodarone
• amphetamines (e.g., Dextroamphetamine, lisdexamphetamine)
• angiotensin II receptor blockers (ARBs; e.g., Candesartan, Losartan)
• antidiabetes medications (e.g., insulin, Metformin, Glyburide)
• atypical anti-psychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
• Azathioprine
• barbiturates (e.g., butalbital, pentobarbital Phenobarbital)
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
• brimonidine
• Bromocriptine
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Canagliflozin
• ciprofloxacin
• conivaptan
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• drospirenone
• Duloxetine
• Eplerenone
• Everolimus
• "gliptin" diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• grass pollen allergen extract
• Guanfacine
• Heparin
• iron dextran complex
• iron gluconate
• levodopa
• lithium
• low-molecular-weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
• medications that increase potassium levels (e.g., potassium supplements, Spironolactone, Amiloride, and salt substitutes containing potassium)
• metformin
• Methylphenidate
• Minoxidil
• nitrates (e.g., Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
• nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., Ibuprofen, Indomethacin, Naproxen)
• other angiotensin-converting-enzyme inhibitors (ACEIs; e.g., captopril,  ramipril)
• Pentoxifylline
• phosphodiesterase-5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• Pregabalin
• quinine
• Ropinirole
• sacubitril
• Selegiline
• Sirolimus
• sodium phosphates
• Temsirolimus
• Tizanidine
• tolcapone
• Tolvaptan
• Trimethoprim
• Yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

HEALTH CANADA ADVISORY

February 4, 2014

Health Canada has issued new restrictions concerning the use of Vasotec IV (Enalapril). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Angioedema: Angioedema (a serious allergic reaction that causes the area around the throat and tongue to swell) may occur with ACE inhibitors, including Vasotec IV (Enalapril), although uncommonly. If you experience swelling of the face, tongue, or throat, you should stop taking Vasotec IV (Enalapril) at once and get immediate medical attention. People who have had angioedema caused by other substances may be at increased risk of angioedema while receiving an ACE inhibitor such as Vasotec IV (Enalapril).

Cough: People taking Vasotec IV (Enalapril) may develop a dry, persistent cough that usually disappears only after stopping or lowering the Vasotec IV (Enalapril) dose. Be sure to tell your doctor of any cough that does not seem to be related to a usual cause.

Diabetes: Vasotec IV (Enalapril) may cause a loss of blood glucose control, and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Vasotec IV (Enalapril). If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Vasotec IV (Enalapril) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: Changes in kidney function have been seen in certain people taking Vasotec IV (Enalapril). The use of diuretics (water pills) or aliskiren may further increase the risk of kidney problems for those already at risk for this problem. If you have kidney disease, discuss with your doctor how Vasotec IV (Enalapril) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Vasotec IV (Enalapril), and whether any special monitoring is needed.

Liver function: Changes in liver function have occurred in people with or without preexisting liver problems during treatment with Vasotec IV (Enalapril). In most cases, the changes were reversed when the medication was stopped. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Occasionally, blood pressure drops too low after taking Vasotec IV (Enalapril). This usually happens after the first or second dose or when the dose is increased. It is more likely to occur in those who take aliskiren, are on dialysis, are experiencing diarrhea or vomiting, are sweating excessively and not drinking enough fluids, have a salt-restricted diet, or are taking water pills. People with these conditions should be monitored closely by their doctor for the first weeks of treatment and whenever the dose of the medication is increased. To reduce the risk of dizziness, get up slowly from a lying down or sitting position. If low blood pressure causes you to faint or feel lightheaded, contact your doctor.

Excessive sweating and lack of fluid intake may lead to an excessive fall in blood pressure because of reduced fluid in your blood vessels. Vomiting or diarrhea may also lead to a fall in blood pressure. Consult your doctor if you feel your blood pressure is too low.

Potassium levels: Increases in blood levels of potassium occur for a small percentage of people taking Vasotec IV (Enalapril). This rarely causes problems, but potassium levels should be monitored by your doctor. Avoid using salt substitutes that contain potassium while you are taking Vasotec IV (Enalapril).

Pregnancy: ACE inhibitors such as Vasotec IV (Enalapril) may cause severe harm or death to the developing fetus if taken by the mother during pregnancy. Vasotec IV (Enalapril) should not be used during pregnancy. If you become pregnant while taking Vasotec IV (Enalapril), contact your doctor immediately.

Breast-feeding: Vasotec IV (Enalapril) passes into breast milk in small amounts. If you are a breast-feeding mother and are taking Vasotec IV (Enalapril), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Vasotec IV (Enalapril) have not been established for infants and children with decreased kidney function.

Seniors: Seniors have an increased risk of experiencing side effects when taking enalalpril due to reduced kidney function. Lower doses may be necessary to minimize side effects.

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