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Cipher Pharmaceuticals



What is Actikerall?

Fluorouracil - salicylic acid is a combination of two medications. Together they are used to reduce the growth of skin lesions called Actinic Keratosis on the face, forehead, and balding scalp.

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Fluorouracil - salicylic acid is a combination of two medications. Together they are used to reduce the growth of skin lesions called Actinic Keratosis on the face, forehead, and balding scalp. These lesions are caused by sun damage to the skin. If not treated, they may become cancerous.

Fluorouracil belongs to the class of medications antineoplastics. It works by interfering with cell division and growth to slow down the growth of cells. It is most active in cells that are growing quickly, such as skin cells affected by actinic keratosis. Salicylic acid is a keratolytic: it breaks down the outer layer of the skin to allow fluorouracil to be absorbed more effectively.

Actikerall may be available under multiple brand names and/or in several different forms. Any specific brand name of Actikerall may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Actikerall may not be used for all of the conditions discussed here.

Your doctor may have suggested Actikerall for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Actikerall, speak to your doctor. Do not stop taking Actikerall without consulting your doctor.

Do not give Actikerall to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Actikerall if their doctor has not prescribed it.



The usual adult dose of fluorouracil - salicylic acid is 1 application of the solution to the lesions, once daily. Several lesions may be treated at a time, but the area being treated should not be larger than 25 cm² (5 cm × 5 cm). A total of 10 lesions may be treated at a time.

Fluorouracil - salicylic acid should only come into contact with the lesion and a very small area of healthy skin surrounding the lesion.

Clean the affected area with warm water and wait until the skin has completely dried before applying the solution.

Actikerall comes in a bottle with a brush applicator attached to the cap. Wipe the brush on the neck of the bottle before applying it to the affected area. After applying the solution to the lesion, let the solution dry on the skin, uncovered. A white film will form over the affected area. This improves the absorption of the medication into the lesion and protects the lesion from dirt and debris. Do not cover the treatment area with any type of dressing. Before applying the next dose, peel the film off the lesion to expose it to the next dose of medication. Warm water may also help remove the film.

Do not allow Actikerall to come in contact with the eyes, the inside of the nose or mouth, or the genitals. Close the lid of the bottle tightly after using to prevent it from drying out. Do not use Actikerall if it dries out or forms any crystals.

Actikerall usually starts to work within 6 weeks. Continue to use the medication for up to 12 weeks or until the lesions have completely cleared up. It may take up to 8 weeks after stopping the medication for the lesions to completely heal.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use Actikerall exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Actikerall at room temperature, protect it from light and moisture, and keep it out of the reach of children. Actikerall is flammable. Keep it away from fire or flames. If there is any medication left in the bottle 3 months after opening it, safely discard the remaining medication.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Actikerall. If you are concerned about side effects, discuss the risks and benefits of Actikerall with your doctor.

The following side effects have been reported by at least 1% of people taking Actikerall. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • dry eyes, eye itching, or increased tearing
  • headache
  • mild-to-moderate irritation where solution is applied (e.g., skin redness, inflammation, burning, pain, itch)
  • skin discoloration
  • skin peeling

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • severe skin irritation (e.g., bleeding, scab, redness, swelling)
  • stomach-flu-like symptoms (e.g., Diarrhea, nausea, vomiting)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of high blood levels of fluorouracil (e.g., stomach pain, nausea, vomiting, diarrhea, unusual bleeding or bruising, black stools)
  • symptoms of high blood levels of salicylic acid (e.g., ringing in the ears, breathing fast, hast heartbeat, confusion, tiredness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Actikerall.


Available form

Each 1 mL of clear, colourless to slightly orange-white solution contains 0.5% fluorouracil and 10% salicylic acid. Nonmedicinal ingredients: dimethyl sulfoxide, ethanol, ethyl acetate, pyroxyline, poly(butyl metacrylate, methyl methacrylate).



Do not take Actikerall if you:

  • are allergic to fluorouracil, salicylic acid, or any ingredients of the medication
  • are allergic to Capecitabine
  • are allergic to salicylates
  • have reduced kidney function
  • are pregnant
  • are breast-feeding
  • have a condition known as dihydropyrimidine dehydrogenase (DPD) deficiency
  • are taking medications that interfere with DPD



There may be an interaction between fluorouracil - salicylic acid and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Actikerall. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.



Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Actikerall.

Diabetes: If you have diabetes, you may not notice severe reactions to Actikerall, particularly if you are applying Actikerall to an area of skin that you cannot see. Your doctor should closely monitor the progress of your treatment to avoid severe skin reactions.

Skin sensitivity: The area that is treated with Actikerall will be more sensitive to exposure to the sun. An exaggerated Sunburn reaction may occur. Avoid exposure to excessive sunlight, including sunlamps and tanning beds, and use sunblock with minimum SPF 15. It is normal to experience some redness and irritation in the areas where Actikerall has been applied.

Staining: This solution may cause permanent staining to clothing, fabric, or acrylics, such a bathubs. Avoid contact with these until the solution has dried.

Pregnancy: Although Actikerall is applied to the skin and is not expected to be absorbed into the body, other forms of fluorouracil cause harm to the developing baby when used during pregnancy. To avoid exposing the developing baby to Actikerall, it should not be used during pregnancy. If you become pregnant while taking Actikerall, contact your doctor immediately.

Breast-feeding: It is not known if fluorouracil - salicylic acid passes into breast milk. If you are a breast-feeding mother and are taking Actikerall, it may affect your baby. Breast-feeding is not recommended while using Actikerall.

Children: The safety and effectiveness of using Actikerall have not been established for children.

Actikerall frequently asked questions

How To Buy Actikerall Online?

You can buy Actikerall online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Actikerall?

You can consult a Canadian doctor online at Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Actikerall in Canada?

Shipping cost for Actikerall to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada and low dispensing fees to help you get access to treatment.

How to get Actikerall delivered to my home?

You could get Actikerall delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Actikerall in Canada for free?

You can get Actikerall for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Actikerall for free.

Can I consult a doctor online to get Actikerall?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Actikerall.

Can I buy Actikerall without a prescription?

You need a valid prescription to buy Actikerall from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.


All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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