Prescription required

Buy Aklief Online

FREE Shipping in Canada

Available Form:  


Manufacturer name:  


Generic name:  




What is Aklief?

Trifarotene belongs to a group of medications called Acne therapy. Specifically, it is in the category of retinoids.

Canada's Leading Online Pharmacy

We make it unbelievably easy to fill prescriptions, consult with pharmacists, and order medications online

What would you like to do?


Refill your Aklief prescription

Consult a doctor for Aklief over call

Upload your Aklief prescription

Enter your phone to save time & money


By proceeding, you agree to our Terms of Use & Privacy Policy

Aklief Price and Cost Calculator


Total no. of GRAM

Insurance coverage

We accept all insurance plans

Estimated copay


Drug cost


Dispensing fee


Delivery cost


Insurance coverage


**Actual price will depend on the insurance coverage in your province

How much does Aklief cost?

  • The cost of Aklief is $2.7 with us here at PocketPills. The cost of Aklief can be lower if your insurance covers it. To calculate the total price of purchasing Aklief, you should also consider dispensing and delivery fees.

How much is the dispensing fee for Aklief

  • The dispensing cost to order Aklief with us is only $7. Pocketpills aims to offer you the most affordable Aklief price in Canada.
  • Remember, we offer you FREE Shipping in Canada.



Trifarotene belongs to a group of medications called Acne therapy. Specifically, it is in the category of retinoids. It is used to treat acne vulgarison the face and torso of adults and adolescents older than 12 years of age. 

Trifarotene appears to help acne partly by clearing the skin pores and keeping them clear. You will begin to see improvement 4 to 8 weeks after starting the medication, with further improvement as you continue to use the cream.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of Aklief (Trifarotene-topical) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Aklief (Trifarotene-topical), speak to your doctor. Do not stop taking Aklief (Trifarotene-topical) without consulting your doctor.

Do not give Aklief (Trifarotene-topical) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Aklief (Trifarotene-topical) if their doctor has not prescribed it.



To use Aklief (Trifarotene-topical) gently cleanse and dry the skin. Apply a thin layer of cream to cover the affected area once a day, in the evening. A single pump of cream from the container will provide enough cream for the face, including forehead, cheeks, nose and chin. Two pumps will provide enough cream to cover the upper back, shoulders and chest. If needed, one additional pump may be used for the middle and lower back. Apply the cream only to the areas that are affected by acne.

Take special care to minimize contact with the eyes, lips, and other easily irritated areas. Make sure the skin is dry before application. If you apply a moisturizer before Aklief (Trifarotene-topical), allow it to absorb into the skin before applying the trifarotene cream.

Wash your hands with soap and water after applying this medication.

Aklief (Trifarotene-topical) may cause increased sensitivity of the skin to sunlight. Sunscreen (minimum SPF 30) and protective clothing should be used when the skin is exposed to sunlight. Avoid getting the medication in your eyes, and do not take the medication by mouth. Do not cover the treatment areas with dressings or bandages. Do not apply to skin that is broken or severely inflamed. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor. It is important to apply this medication exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Aklief (Trifarotene-topical) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Aklief (Trifarotene-topical). If you are concerned about side effects, discuss the risks and benefits of Aklief (Trifarotene-topical) with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • burning
  • dryness
  • loss of skin pigment
  • peeling
  • skin redness
  • stinging

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of an allergic reaction (e.g., extreme stinging, burning, redness, swelling)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Aklief (Trifarotene-topical).


Available form

Each gram of white cream contains 50 µg trifarotene. Nonmedicinal ingredients: allantoin, copolymer of acrylamide and sodium acryloyldimethyltaurate with isohexadecane, polysorbate 80 and sorbitan oleate, cyclomethicone 5, ethanol (96% alcohol), phenoxyethanol, propylene glycol, triglycerides medium-chain and purified water.



Do not take this medication if you:

  • are allergic to trifarotene or any ingredients of the medication
  • are pregnant or planning to become pregnant
  • have Eczema or seborrheic dermatitis



There may be an interaction between trifarotene and any of the following:

  • other medications that increase the skin’s sensitivity to sun exposure (e.g., certain diuretics, quinolone antibiotics, Tetracycline antibiotics, certain sedatives, “sulfa” antibiotics)
  • other acne medications that contain sulfur, resorcinol or salicylic acid

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Aklief (Trifarotene-topical). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.



Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Aklief (Trifarotene-topical).

Exposure to sunlight: Aklief (Trifarotene-topical) can make the skin more sensitive to sunlight. Make sure you use sunscreen (minimum SPF 30) and protective clothing when exposed to sunlight. If you have a Sunburn, you should not use trifarotene until you have fully recovered.

Skin Care: Trifarotene can make your skin dry and possibly irritated. It is important to avoid using other skin products or treatments with strong drying or irritant effects. These products and procedures may include electrolysis, hair depilatories, medicated soaps or shampoos, permanent wave solution, waxes, and products containing high amounts of alcohol, astringents, spices, or lime peel.

Exposure to wind and cold may also dry and irritate your skin.

Other acne medications may contribute to skin irritation. Discuss your options with your doctor.

Pregnancy: It is recommended that pregnant women do not use trifarotene. When similar medications have been taken by mouth during pregnancy, the babies born to these women were at an increased risk of birth defects. Because the amount of Aklief (Trifarotene-topical) that is absorbed through the skin varies, there is a risk that the unborn baby may be exposed to trifarotene if it is used during pregnancy. Women who may become pregnant should use an effective method of birth control while using Aklief (Trifarotene-topical). If you become pregnant while taking Aklief (Trifarotene-topical), contact your doctor immediately.

Breast-feeding: It is not known if trifarotene passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of this medication have not been established for children less than 12 years of age.

Aklief frequently asked questions

How To Buy Aklief Online?

You can buy Aklief online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Aklief?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Aklief in Canada?

Shipping cost for Aklief to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada and low dispensing fees to help you get access to treatment.

How to get Aklief delivered to my home?

You could get Aklief delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Aklief in Canada for free?

You can get Aklief for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Aklief for free.

Can I consult a doctor online to get Aklief?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Aklief.

Can I buy Aklief without a prescription?

You need a valid prescription to buy Aklief from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.


All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

Reading is good for you...

Reading about what's good for you is even better.

Type 1 and Type 2 Diabetes
All about Erectile Dysfunction (ED) Medications
How Effective Is Bupropion In Treating Seasonal Affective Disorder?

Related Drugs

Already a member?

Sign In
You're almost there!

Simply sign in to join
our 100k+ satisfied members:



By proceeding, you agree to our Terms of Use & Privacy Policy

Prefer to sign up over the phone?

Our care team can't wait to take your call!


Refill your Aklief prescription 

You don't have to wait in line at the store to fill your prescriptions. You can have your doctor fax your prescription to them, input the details of your old pharmacy online, or take a picture of your prescription with the online pharmacy app.

Get an online prescription for Aklief from a Canadian doctor now

Skip the waiting room! See a Canadian doctor online, for free and get treated for any common condition on your phone. 

*Note: Fully covered with a British Columbia, Alberta, Manitoba or Ontario health card

Upload your Aklief prescription

Upload a picture of your prescription(s), allowing us to receive an image of your prescription and begin the process of filling your prescription(s). However, we will require the original hard copy of your prescription to be sent to us in order to complete filling your prescription.