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August 8, 2022

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Available Form:
Injectable
Manufacturer name:
Sanofi-Aventis
Generic name:
laronidase
Strength:
0.58mg/ml
Aldurazyme (Laronidase) is used to treat mucopolysaccharidosis I (MPS I), a genetic disorder where the body does not have enough of an enzyme called alpha-L-iduronidase. Without this enzyme, substances called glycosaminoglycans (GAGs) build up in the body, causing tissue and organ damage.
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Aldurazyme (Laronidase) is used to treat mucopolysaccharidosis I (MPS I), a genetic disorder where the body does not have enough of an enzyme called alpha-L-iduronidase. Without this enzyme, substances called glycosaminoglycans (GAGs) build up in the body, causing tissue and organ damage.
Aldurazyme (Laronidase) works by replacing the missing enzyme, which helps the body break down GAGs - a process known as enzyme replacement therapy (ERT). Aldurazyme (Laronidase) is used to treat the symptoms of MPS I that occur in parts of the body other than the brain and spinal cord.
Your doctor may have suggested Aldurazyme (Laronidase) for conditions other than those listed in these drug information articles. As well, some forms of Aldurazyme (Laronidase) may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given Aldurazyme (Laronidase), speak to your doctor. Do not stop receiving Aldurazyme (Laronidase) without consulting your doctor.
The recommended dose is 0.58 mg per kilogram of body weight given once per week. Aldurazyme (Laronidase) is given by intravenous (into a vein) infusion over a period of 3 to 4 hours in a clinic or hospital setting. An experienced doctor must supervise the treatment. You should keep all your appointments and follow-ups as recommended by your doctor.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.
It is important to receive Aldurazyme (Laronidase) exactly as recommended by your doctor. If you miss an appointment to receive Aldurazyme (Laronidase), contact your doctor as soon as possible to reschedule your appointment.
Aldurazyme (Laronidase) is stored in the refrigerator. It should not be shaken or allowed to freeze.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Aldurazyme (Laronidase). If you are concerned about side effects, discuss the risks and benefits of Aldurazyme (Laronidase) with your doctor.
The following side effects have been reported by at least 1% of people taking Aldurazyme (Laronidase). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor or pharmacist if you notice any symptom that worries you while you are taking Aldurazyme (Laronidase).
Each mL of sterile, colourless-to-pale-yellow, clear-to-slightly-opalescent solution contains 0.58 mg of Aldurazyme (Laronidase). The vial does not contain preservatives. Nonmedicinal ingredients: polysorbate 80, sodium chloride, sodium phosphate monobasic monohydrate, sodium phosphate dibasic heptahydrate, and water for injection.
Aldurazyme (Laronidase) should not be used by anyone who is allergic to Aldurazyme (Laronidase) or to any of the ingredients of the medication.
There may be an interaction between Aldurazyme (Laronidase) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Aldurazyme (Laronidase). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Aldurazyme (Laronidase).
Health Canada has issued new restrictions concerning the use of Aldurazyme® (Aldurazyme (Laronidase)). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Kidney or liver function: The safety and effectiveness of Aldurazyme (Laronidase) are not known in people with reduced kidney or liver function. People with reduced kidney or liver function should discuss with their doctor how Aldurazyme (Laronidase) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Aldurazyme (Laronidase), and whether any special monitoring is needed.
Premedication: Most people who receive Aldurazyme (Laronidase) will also be given medications (e.g., Acetaminophen, Diphenhydramine) to reduce infusion-related side effects such as fever, chills, headache, and flushing. These medications are usually given about 60 minutes before Aldurazyme (Laronidase) is given.
Pregnancy: Aldurazyme (Laronidase) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while receiving Aldurazyme (Laronidase), contact your doctor immediately.
Breast-feeding: It is not known if Aldurazyme (Laronidase) passes into breast milk. If you are a breast-feeding mother and are receiving Aldurazyme (Laronidase), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Aldurazyme (Laronidase) have not been established for children less than 6 months old.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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