This combination product contains two medications: clindamycin and benzoyl peroxide. Clindamycin belongs to the family of medications known as antibiotics. Benzoyl peroxide is a medication that has antibacterial effects and is a peeling agent. This combination product is used to treat certain types of Acne. It works by killing bacteria that cause acne and by peeling off skin cells. It may take several weeks to months for your acne to improve.

Clindoxyl may be available under multiple brand names and/or in several different forms. Any specific brand name of Clindoxyl may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Clindoxyl may not be used for all of the conditions discussed here.

Your doctor may have suggested Clindoxyl for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Clindoxyl, speak to your doctor. Do not stop using Clindoxyl without consulting your doctor.

Do not give Clindoxyl to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Clindoxyl if their doctor has not prescribed it.

Clindamycin - benzoyl peroxide should be applied to the affected skin areas once daily before bedtime. Wash your skin, rinse with warm water, gently pat dry, and then apply the medication. Avoid contact with eyes, nostrils, mouth, and sensitive skin. If contact does occur, rinse with plenty of cool tap water. Wash your hands before and after using Clindoxyl.

It is important to use Clindoxyl exactly as prescribed by your doctor.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

Store Clindoxyl at room temperature, keep tube tightly closed and keep out of the reach of children. Discard any unused gel after 60 days.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Clindoxyl. If you are concerned about side effects, discuss the risks and benefits of Clindoxyl with your doctor.

The following side effects have been reported by at least 1% of people taking Clindoxyl. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• skin peeling, redness, dryness, burning, or itching at the application site
• sensitivity to sunlight

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• abdominal pain or cramps, severe pain or bloating
• nausea and vomiting
• severe watery Diarrhea that may be bloody

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of an allergic reaction (e.g., rash, Hives, swelling of the lips or face, difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Clindoxyl.

Each 1 g of gel contains 10 mg of clindamycin and 50 mg of benzoyl peroxide. Nonmedicinal ingredients: carbomer homopolymer, dimethicone, disodium lauryl sulfosuccinate, edetate disodium, glycerin, silicon dioxide, methylparaben, poloxamer, purified water, and sodium hydroxide.

Do not take Clindoxyl if you:

• are allergic to clindamycin, lincomycin, benzoyl peroxide, or to any of the ingredients of Clindoxyl
• have a history of colitis associated with antibiotic use
• have a history of Crohn's Disease, Ulcerative Colitis, or inflammation of the small intestine

There may be an interaction between clindamycin - benzoyl peroxide and any of the following:

• BCG vaccine
• erythromycin
• neuromuscular blocking agents (e.g., tubocurarine, pancuronium)
• other acne medications (e.g., Dapsone)
• sulphonamides (topical)
• Tazarotene
• tretinoin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Clindoxyl. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.