Differin XP

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0.1%, 0.3%

What is Differin XP?

Differin XP (Adapalene) belongs to a family of medications known as retinoids.  It is used to treat common forms of Acne.

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Differin XP frequently asked questions

How To Buy Differin XP Online?

You can buy Differin XP online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Differin XP?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Differin XP in Canada?

Shipping cost for Differin XP to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Differin XP delivered to my home?

You could get Differin XP delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Differin XP in Canada for free?

You can get Differin XP for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Differin XP for free.

Can I consult a doctor online to get Differin XP?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Differin XP.

Can I buy Differin XP without a prescription?

You need a valid prescription to buy Differin XP from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.

Differin XP Uses

Differin XP (Adapalene) belongs to a family of medications known as retinoids. It is used to treat common forms of Acne. It works by reducing the number of acne-blocked oil glands (plugs or comedones) and preventing the formation of the plugs. You may see an improvement in acne in about 4 to 8 weeks.

Differin XP (Adapalene) may be available under multiple brand names and/or in several different forms. Any specific brand name of Differin XP (Adapalene) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Differin XP (Adapalene) may not be used for all of the conditions discussed here.

Your doctor may have suggested Differin XP (Adapalene) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are using Differin XP (Adapalene), speak to your doctor. Do not stop using Differin XP (Adapalene) without consulting your doctor.

Do not give Differin XP (Adapalene) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Differin XP (Adapalene) if their doctor has not prescribed it.

Differin XP Dosage

Apply a thin layer of Differin XP (Adapalene) once a day before bedtime after washing the area with a gentle cleanser and drying gently with a towel. It should be applied to all the areas that are prone to acne; this may include the chest and back as well as the face. Do not apply Differin XP (Adapalene) to cuts, open wounds, sunburned areas, or areas of the skin with Eczema.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Differin XP (Adapalene) exactly as prescribed by your doctor. If you miss one application, do not apply it more than once per day. Skip the missed dose and continue with your regular dosing schedule the following day at bedtime. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing an application, contact your doctor or pharmacist for advice.

Store Differin XP (Adapalene) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Differin XP Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses Differin XP (Adapalene). If you are concerned about side effects, discuss the risks and benefits of Differin XP (Adapalene) with your doctor.

The following side effects have been reported by at least 1% of people using Differin XP (Adapalene). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • burning or stinging
  • discomfort
  • dry skin
  • itchiness
  • peeling
  • redness
  • skin irritation
  • Sunburn

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • excessively dry, red, swollen, or blistered skin

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Differin XP (Adapalene).

Differin XP Available form

Each g of topical gel contains Differin XP (Adapalene) 0.3% (3 mg). Nonmedicinal ingredients: carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water, and sodium hydroxide and/or hydrochloric acid for pH adjustment.

Differin XP Contraindications

Do not use Differin XP (Adapalene) if you:

  • are allergic to Differin XP (Adapalene) or any other ingredients of the medication
  • have eczema or seborrheic dermatitis
  • are pregnant or planning to become pregnant

Differin XP Precautions

There are no known interactions with other medications when Differin XP (Adapalene) is used as directed. However, Differin XP (Adapalene) can irritate the skin, so other products such as harsh or abrasive cleansers, strong drying agents or other products that may be irritating should be avoided in the areas of the skin where Differin XP (Adapalene) is applied. Many over-the-counter acne medications contain sulfur, resorcinol or salicylic acid. It is best to stop using these before starting Differin XP (Adapalene) therapy. When using other topical acne medications (e.g., erythromycin topical solution, clindamycin phosphate topical solution or benzoyl peroxide), it is best to use Differin XP (Adapalene) at night and the others in the morning.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Differin XP Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Differin XP (Adapalene).

Area of use: Differin XP (Adapalene) is for external use only. Do not apply to areas near the eyes, lips, angles of the nose, mucous membranes, and open wounds.

Cosmetics: Avoid the use of certain cosmetics that might make your skin worse. Ask a cosmetician for non-comedogenic cosmetics or use water-based makeup. Remove any makeup before applying Differin XP (Adapalene).

Sunlight: Avoid exposure to excessive sunlight (outdoors, sunlamps, and tanning beds). If sun exposure cannot be avoided, use a sunscreen (minimum SPF 30). Waxing as a hair removal method should be avoided.

Pregnancy: Women who are pregnant or considering pregnancy should not use Differin XP (Adapalene). Women who use Differin XP (Adapalene) should ensure that they are using adequate birth control while they are using Differin XP (Adapalene).

Breast-feeding: It is not known if Differin XP (Adapalene) passes into breast milk. If you are a breast-feeding mother and are taking Differin XP (Adapalene), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Differin XP (Adapalene) have not been established for children under the age of 12.

Seniors: The safety and effectiveness of using Differin XP (Adapalene) have not been established for people over the age of 65.


All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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