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Elaprase

Elaprase

Idursulfase

Elaprase (Idursulfase) belongs to the class of medications called enzyme replacement therapies (ERT). It is used to help improve walking capacity for people with Hunter syndrome, or mucopolysaccharidosis II (MPS II).

Available form

Injectable

Dosage

2mg/ml

Manufacturers

Takeda

Generic brand of

Idursulfase

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Elaprase information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual dose of Elaprase (Idursulfase) is based on body weight at 0.5 mg per kg. It is given every week by intravenous (into a vein) infusion, usually over 1 to 3 hours. Elaprase (Idursulfase) is always prepared and given by a health care professional.

It is important to receive Elaprase (Idursulfase) exactly as prescribed by your doctor. If you cannot keep an appointment to receive your medication, contact your doctor for advice.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.

Elaprase (Idursulfase) is stored in the refrigerator at 2°C to 8°C and should be kept out of the reach of children. Do not freeze or shake Elaprase (Idursulfase).

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Elaprase (Idursulfase). If you are concerned about side effects, discuss the risks and benefits of Elaprase (Idursulfase) with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Acne
Diarrhea
ear problems
Eczema
heartburn
increased tear production
joint pain
nausea
sore throat
tremor
upper abdominal pain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

dizziness
Fever
infusion reactions (e.g., headache, rash, itching, flushing redness, Hives, high blood pressure)
increased blood pressure
skin rash
swelling at the place of injection
swelling of the feet, ankles, or hands

Stop taking the medication and seek immediate medical attention if any of the following occur:

abnormal heart rhythm(skipped or extra heartbeats)
bluish skin colour (e.g., lips)
chest pain
seizures
signs of a blood clot in the lung (e.g., difficulty breathing, cough, chest pain, increased breathing rate)
signs of a Anaphylaxis (severe allergic reaction) (e.g., hives; difficulty breathing; wheezing; dizziness; seizure; swelling of the face, lips, tongue, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Elaprase (Idursulfase).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Elaprase (Idursulfase).

Allergic reactions: Elaprase (Idursulfase) can cause serious allergic reactions that can be life-threatening. If you experience hives; difficulty breathing; bluish skin; seizures; severe dizziness; or swelling of the face, tongue, mouth, or lips while receiving Elaprase (Idursulfase), get immediate medical attention. In some cases, people who have had an allergic reaction to Elaprase (Idursulfase) will get more allergy symptoms after the infusion has stopped. If this occurs, get immediate medical attention.

Infusion-related reactions: Infusion-related reaction caused by Elaprase (Idursulfase) can include skin rash, itchy skin, fever, headache, flushing, hives, and high blood pressure. If these occur, you doctor may suggest that the infusion be slowed down or stopped temporarily. Your doctor may also recommend medications such as antihistamines and corticosteroids to reduce or prevent infusion-related reactions.

Lung problems: People with poor lung function or other lung problems may be more likely to experience infusion-related reactions. Infusion-related reactions include headache, rash, itchy skin, red skin, and high blood pressure. Your doctor will monitor you closely if you have lung problems and are receiving Elaprase (Idursulfase).

Pregnancy: Elaprase (Idursulfase) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Elaprase (Idursulfase), contact your doctor immediately.

Breast-feeding: It is not known if Elaprase (Idursulfase) passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Elaprase (Idursulfase) have not been established for children under 5 years of age.

Seniors: The safety and effectiveness of using Elaprase (Idursulfase) have not been established for seniors.

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