Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Flagystatin. If you are concerned about side effects, discuss the risks and benefits of Flagystatin with your doctor.

The following side effects have been reported by at least 1% of people taking Flagystatin. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Constipation
• darker urine
• Dry Mouth
• granular sensation in the vagina
• headache
• heartburn
• loss of appetite
• metallic taste or other change in taste sensation
• minor itching, burning, or irritation in the vagina
• nausea
• trouble sleeping
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• difficulty moving
• fast heartbeat or skipped heartbeats
• flu-like symptoms (e.g., Fever, chills, body aches, sore throat, extreme tiredness)
• signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• signs of liver problems (e.g., nausea, vomiting, Diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• tingling feeling on skin

Stop taking the medication and seek immediate medical attention if any of the following occur:

• chest pain
• seizures
• signs of Meningitis (e.g., sudden high fever, headache, stiff neck, confusion, nausea and vomiting)
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Flagystatin.

Vaginal cream
Each full applicator of cream delivers metronidazole 500 mg and nystatin 100,000 units. Nonmedicinal ingredients: glycerin, glyceryl monostearate, methylparaben, propylparaben, purified water, stearic acid, and trolamine.

Vaginal ovules
Each ovule contains metronidazole 500 mg and nystatin 100,000 units. Nonmedicinal ingredient: glycerides of saturated fatty acid (hard fat).

Do not use metronidazole - nystatin vaginal if you:

• are allergic to metronidazole, nystatin, or any other ingredients of Flagystatin
• are taking oral (by mouth) metronidazole and also have an active neurological disorder, a history of blood disorders, an underactive Thyroid, or underactive adrenal glands

There may be an interaction between metronidazole - nystatin vaginal and any of the following:

• alcohol
• barbiturates (e.g., Phenobarbital)
• BCG vaccine
• Busulfan
• Cyclosporine
• disulfiram
• lithium
• lopinavir
• Phenytoin
• Progesterone (vaginal)
• sodium picosulfate
• tipranavir
• Warfarin
• 5-fluorouracil

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Flagystatin.

Alcohol: A severe set of side effects including nausea, vomiting, and rapid heartbeat may occur if you consume alcohol while taking metronidazole. Although this usually occurs with the oral (taken by mouth) form of metronidazole, it is possible to experience this reaction with the vaginal form of metronidazole. If you are taking this medication, wait until at least one day after finishing treatment before drinking alcohol.

Confusion/dizziness: This medication may cause confusion or dizziness. Avoid driving or other tasks requiring alertness if the medication affects you in this way.

Effectiveness of other products: Condoms and diaphragms may be less effective while using metronidazole - nystatin vaginal cream or ovule. Other methods of birth control should be used while you are taking Flagystatin.

Liver function: Metronidazole may reduce liver function and can cause liver failure. Although this is more common with the form of metronidazole that is taken by mouth, it can occur with the vaginal form. If you have severe liver disease, this medication may build up in the body, causing side effects.

If you have decreased liver function or have had liver problems in the past as a result of taking metronidazole, discuss with your doctor how Flagystatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Flagystatin, and whether any special monitoring is needed. Your doctor may want to test your liver function with blood tests while you are taking Flagystatin.

Male partner: When there is evidence of infection in a male sexual partner, he should be treated at the same time with oral metronidazole (taken by mouth) to avoid re-infection.

Neurological side effects: Stop treatment with Flagystatin and see your doctor if muscle incoordination, seizures, or numbness or tingling in the hands or feet occur.

Personal hygiene: Menstrual tampons and soaps with an acid pH should not be used while you are using this medication. These products may promote the growth of fungi, making treatment more difficult.

Side effects: It is possible (but much less likely) that side effects normally associated with the use of oral metronidazole may occur following the use of metronidazole used vaginally.

Underclothing: To help the infection go away more quickly, wear cotton (instead of synthetic) underwear or pantyhose with cotton gussets.

Pregnancy: Flagystatin has not been studied for use by pregnant women. Flagystatin should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Flagystatin, contact your doctor immediately. The applicator should not be used after the seventh month of pregnancy.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are using metronidazole - nystatin vaginal, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.