Fluorouracil belongs to a group of medications called antineoplastics. It is used topically to treat a type of Skin Cancer known as superficial basal cell carcinoma.
Available form
Cream
Dosage
Manufacturer
Allergan
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Wash the area to be treated with soap and water, then dry the area thoroughly. Apply the cream to the affected area twice a day with a nonmetal applicator (e.g., a cotton swab) or while wearing a suitable glove. Apply a thin layer, enough to cover the entire affected area of the skin. If fingertips are used to apply, wash your hands well with soap and water immediately afterwards.
Avoid contact with the eyes, eyelids, corners of the nose and mouth, easily irritated areas, or other areas where treatment is not intended. If you apply the medication near the eyes, nose, or mouth, take care to avoid getting the medication in these sensitive areas.
Fluoroplex (Fluorouracil-topical) will cause the skin to become severely inflamed and irritated, but continue to use it for the length of time recommended by your doctor, usually for 2 to 4 weeks. Complete healing of the treated area may take 1 to 2 months after stopping treatment. If the area becomes severely irritated, contact your doctor.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important to use Fluoroplex (Fluorouracil-topical) exactly as prescribed by your doctor. If you miss a dose, apply it as soon as possible and continue with your regular schedule. If more than a few hours have passed, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, or you have missed more than one dose, contact your doctor or pharmacist for advice.
Store Fluoroplex (Fluorouracil-topical) at room temperature and protect it from light, heat, and moisture. Keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who uses Fluoroplex (Fluorouracil-topical). If you are concerned about side effects, discuss the risks and benefits of Fluoroplex (Fluorouracil-topical) with your doctor.
The following side effects have been reported by at least 1% of people using Fluoroplex (Fluorouracil-topical). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Fluoroplex (Fluorouracil-topical).
Fluoroplex is no longer being manufactured for sale in Canada. For brands that may still be available, search under fluorouracil. This article is being kept available for reference purposes only. If you are using Fluoroplex (Fluorouracil-topical), speak with your doctor or pharmacist for information about your treatment options.
Do not take Fluoroplex (Fluorouracil-topical) if you:
There may be an interaction between fluorouracil and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Fluoroplex (Fluorouracil-topical). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Fluoroplex (Fluorouracil-topical).
Covering the affected area: Applying this cream and then covering it with a dressing that doesn't allow air to contact the skin may increase skin irritation caused by Fluoroplex (Fluorouracil-topical). If you are unsure whether to cover the affected area, call your doctor for advice.
Dihydropyrimidine dehydrogenase (DPD) deficiency: The enzyme dihydropyrimidine dehydrogenase breaks down fluorouracil in the body. Fluoroplex (Fluorouracil-topical) should not be used by people with a known DPD deficiency since accumulation of fluorouracil can result in severe side effects.
Sunlight exposure: Fluorouracil may increase your sensitivity to the sun. Prolonged exposure to sunlight, sunlamps, wind, and cold should be avoided during treatment as these may cause more irritation. If you cannot avoid exposure to sunlight, use sunscreen products with a sun protection factor (SPF) of 30 or higher, and wear protective clothing over treated areas if possible. The sunscreen should be reapplied after swimming. If Sunburn occurs, stop using the medication and call your doctor for advice.
Pregnancy: Fluoroplex (Fluorouracil-topical) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Fluoroplex (Fluorouracil-topical), contact your doctor immediately.
Breast-feeding: It is not known if fluorouracil passes into breast milk. If you are a breast-feeding mother and are using Fluoroplex (Fluorouracil-topical), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Fluoroplex (Fluorouracil-topical) have not been established for children.
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