Glucagen Hypokit (Glucagon) belongs to the group of medications called hyperglycemic agents. It is used to treat severe Hypoglycemia (low blood sugar) when someone with insulin-treated Diabetes is unable to give glucose to themselves (e.g., unconscious). Symptoms of severely low blood sugar include disorientation, unconsciousness, and seizures.

Glucagen Hypokit (Glucagon) works in the liver to produce glucose (sugar) and increase blood sugar. It usually works within 10 to 15 minutes. If a person does not respond to Glucagen Hypokit (Glucagon) within 10 to 15 minutes, get immediate medical attention.

Glucagen Hypokit (Glucagon) can also be used as part of certain radiologic tests to temporarily reduce the movement of the stomach and intestines.

Glucagen Hypokit (Glucagon) may be available under multiple brand names and/or in several different forms. Any specific brand name of Glucagen Hypokit (Glucagon) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Glucagen Hypokit (Glucagon) may not be used for all of the conditions discussed here.

Your doctor may have suggested Glucagen Hypokit (Glucagon) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Glucagen Hypokit (Glucagon), speak to your doctor.

Do not give Glucagen Hypokit (Glucagon) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Glucagen Hypokit (Glucagon) if their doctor has not prescribed it.

[for GlucaGen]

The usual dose for adults and children who weigh more than 25 kg (55 lbs) and are 6 to 8 years and older is 1 mg (1 unit) injected into a muscle. For children who weigh less than 25 kg (55 lbs) and are younger than 6 to 8 years, the dose is 0.5 mg (0.5 units) or based on body weight.

To give a Glucagen Hypokit (Glucagon) injection, first prepare the injection. Do not prepare the injection until the medication is needed. Once prepared, use it immediately and do not store for later use.

1. Remove the plastic cap from the vial.
2. Pull the needle cap cover off the syringe.
3. Draw up the water for injection (1.1 mL) in a disposable syringe (not needed for Hypokit).
4. Insert the needle through the rubber stopper (within the marked circle) and inject the water for injection into the vial containing the freeze-dried Glucagen Hypokit (Glucagon).
5. Without taking the needle out of the vial, shake the vial gently until the Glucagen Hypokit (Glucagon) is completely dissolved and the solution is clear.
6. Make sure the plunger is completely down. While keeping the needle in the liquid, slowly withdraw the solution back into the syringe.
7. Remove any air bubbles from the syringe by tapping on the needle with the needle pointing upwards, and push the plunger slightly to release any air that has collected at the top of the syringe.
8. Continue to push the plunger until you have the correct dose.
9. Inject into a muscle.

As soon as someone responds to Glucagen Hypokit (Glucagon), they should eat glucose (e.g., candy, orange juice, regular pop) to prevent low blood sugar from returning and contact their doctor.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you use the medication without consulting your doctor.

It is important that Glucagen Hypokit (Glucagon) be used exactly as prescribed by your doctor.

Store Glucagen Hypokit (Glucagon) in the refrigerator at 2°C to 8°C and keep it out of the reach of children. The Hypokit form of Glucagen Hypokit (Glucagon) can be stored at a temperature no greater than 25°C for up to 18 months, provided the expiry date is not exceeded.

[for Glucagen Hypokit (Glucagon)]

The usual dose of Glucagen Hypokit (Glucagon) for adults and children who weight more than 20 kg (44 lbs) is 1 mg (1 unit) injected under the skin, into a muscle, or into a vein. For children who weight less than 20 kg (44 lbs), the dose is 0.5 mg (0.5 units) or is based on body weight.

Injections into a vein are given by health care professionals with the appropriate training and supplies to do so.

To give a Glucagen Hypokit (Glucagon) injection under the skin, first prepare the injection. Once prepared, use it immediately and do not store for later use.

1. Remove the flip-off seal from the vial (bottle) of Glucagen Hypokit (Glucagon).
2. Remove the needle protector from the syringe, and inject the entire contents of the syringe into the bottle of Glucagen Hypokit (Glucagon). Do not remove the plastic clip from the syringe. Remove the syringe from the bottle.
3. Swirl the bottle gently until the Glucagen Hypokit (Glucagon) dissolves completely. Glucagen Hypokit (Glucagon) should not be used unless the solution is clear and completely dissolved.
4. Using the same syringe, hold bottle upside down and, making sure the needle tip remains in solution, withdraw all of the solution (1 mg mark on syringe) from the bottle. The plastic clip on the syringe will prevent the plunger from being pulled out of the syringe; however, if the plastic plunger rod separates from the rubber stopper, simply reinsert the rod by turning it clockwise.
5. Clean the injection site on the buttock, arm, or thigh with an alcohol swab.
6. Insert the needle into the fatty tissue under the cleaned injection site, and inject the Glucagen Hypokit (Glucagon) solution. There is no danger of overdose.
7. Apply light pressure at the injection site, and withdraw the needle. Press an alcohol swab against the injection site.
8. Turn the patient on their side. When an unconscious person awakens, they may vomit. Turning the patient on their side will prevent them from choking.

As soon as someone responds to Glucagen Hypokit (Glucagon), they should eat glucose (e.g., candy, orange juice, regular pop) to prevent low blood sugar from returning, and they should contact their doctor.

Glucagen Hypokit (Glucagon) is not very helpful when the low blood glucose is due to prolonged fasting, starvation, reduced adrenal function, and chronic low blood sugar. Under these circumstances, it is important to get immediate medical help to treat the low blood sugar.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you use the medication without consulting your doctor.

It is important that Glucagen Hypokit (Glucagon) be used exactly as prescribed by your doctor.

Before adding the diluent to the Glucagen Hypokit (Glucagon) vial, Glucagen Hypokit (Glucagon) may be stored at room temperature.

Keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses.

Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who uses Glucagen Hypokit (Glucagon). If you are concerned about side effects, discuss the risks and benefits of Glucagen Hypokit (Glucagon) with your doctor.

The following side effects have been reported by at least 1% of people using Glucagen Hypokit (Glucagon). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• dizziness
• nausea
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• fast, pounding heartbeat

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs and symptoms of a Anaphylaxis (severe allergic reaction) (Hives, itchy skin, difficulty breathing or swallowing, swelling of the face, mouth, tongue, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Glucagen Hypokit (Glucagon).

GlucaGen

Each 1 mg/mL vial is supplied as a sterile, freeze-dried white powder of Glucagen Hypokit (Glucagon) in a 2 mL vial and accompanying solvent also in a 2 mL vial. Glucagen Hypokit (Glucagon) powder is reconstituted with 1.0 mL of water for injection (WFI), forming a solution of 1 mg (1 IU) Glucagen Hypokit (Glucagon) and 107 mg of lactose monohydrate in each mL prior to use. One stoppered glass vial contains 1 mg Glucagen Hypokit (Glucagon), corresponding to 1 mg glucagon/mL after reconstitution. Nonmedicinal ingredients: lactose monohydrate, hydrochloric acid and/or sodium hydroxide (pH adjusters), and water for injection.

GlucaGen Hypokit
Each 1 mg/mL vial is supplied as a sterile, freeze-dried white powder of Glucagen Hypokit (Glucagon) in a 2 mL vial and accompanying solvent in a 1.5 mL disposable syringe. Glucagen Hypokit (Glucagon) powder is reconstituted with 1.0 mL of water for injection (WFI), forming a solution of 1 mg (1 IU) Glucagen Hypokit (Glucagon) and 107 mg of lactose monohydrate in each mL prior to use. Nonmedicinal ingredients: lactose monohydrate, hydrochloric acid and/or sodium hydroxide (pH adjusters), and water for injection.

Glucagen Hypokit (Glucagon)

Each kit contains 1 rubber-stoppered vial of lyophilized powder containing Glucagen Hypokit (Glucagon) for injection USP 1 unit (1 mg) and 1 prefilled Hyporet of diluting solution. Nonmedicinal ingredients: lactose and glycerin. May contain hydrochloric acid for pH adjustment.

Do not use Glucagen Hypokit (Glucagon) if you:

• are allergic to Glucagen Hypokit (Glucagon) or any ingredients of the medication
• have pheochromocytoma (a tumour on the adrenal glands)

There may be an interaction between Glucagen Hypokit (Glucagon) and any of the following:

• alcohol
• Indomethacin
• insulin
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Glucagen Hypokit (Glucagon). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.