Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Nocdurna (Desmopressin). If you are concerned about side effects, discuss the risks and benefits of Nocdurna (Desmopressin) with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• back pain
• cough
• diarrhea
• dizziness
• Dry Mouth
• headache
• nausea
• tiredness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• symptoms of a urinary tract infection (e.g. pain when urinating, urinating more often than usual, low back or flank pain)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• symptoms of low blood sodium (e.g., unexpected weight gain, confusion, bad headache, nausea or vomiting, loss of appetite, muscle cramps)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Nocdurna (Desmopressin).

25 µg
Each white, round, orally disintegrating tablet with "25" on one side contains 25 µg of Nocdurna (Desmopressin). Nonmedicinal ingredients: gelatin, mannitol, and anhydrous citric acid.

50 µg
Each white, round, orally disintegrating tablet with "50" on one side contains 50 µg of Nocdurna (Desmopressin). Nonmedicinal ingredients: gelatin, mannitol, and anhydrous citric acid.

Do not take Nocdurna (Desmopressin) ODT if you:

• are allergic to Nocdurna (Desmopressin) or any ingredients of the medication
• are using diuretics to treat other medical conditions
• drink excessive amounts of fluid to purposely cause high urine production
• have, or have had, a history of a low level of sodium in the blood
• have a medical condition that causes slow blood clotting (e.g., type IIB or platelet type (pseudo) von Willebrand's disease)
• have a medical condition that causes sodium to be lost from the body (Eating Disorders, chronic Diarrhea or vomiting, adrenal problems)
• have heart problems such as heart failure (cardiac insufficiency)
• have moderate to severely reduced kidney function
• have syndrome of inappropriate antidiuretic hormone (SIADH) secretion

There may be an interaction between Nocdurna (Desmopressin) ODT and any of the following:

• Carbamazepine
• Celecoxib
• Chlorpromazine
• demeclocycline
• Lamotrigine
• lithium
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Ketoprofen, Naproxen)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Duloxetine, Fluoxetine, Paroxetine, Sertraline)
• Tramadol
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Bladder problems: If you have severe bladder or voiding problems, discuss with your doctor how Nocdurna (Desmopressin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Cystic Fibrosis: People with cystic fibrosis are more likely to develop hyponatremia (low blood sodium) than other individuals. If you have cystic fibrosis, discuss with your doctor how Nocdurna (Desmopressin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nocdurna (Desmopressin), and whether any special monitoring is needed.

Fluid and electrolyte balance: Fluid intake should be adjusted in order to reduce the possibility of water retention and low levels of sodium in the blood, especially for seniors. People who are dehydrated should wait until their water balance has been adequately restored before taking Nocdurna (Desmopressin). Seniors should be closely observed for possible water retention and low sodium in the blood due to excessive fluid intake. Talk to your doctor about adjusting your fluid intake to the amount that is right for you. For control of nighttime urination, a restricted fluid intake is recommended a few hours before using Nocdurna (Desmopressin).

Heart disease: Nocdurna (Desmopressin) can cause changes in heart rate and blood pressure. If you have any medical condition affecting your heart, discuss with your doctor how Nocdurna (Desmopressin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: Kidney Disease or reduced kidney function may cause Nocdurna (Desmopressin) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nocdurna (Desmopressin), and whether any special monitoring is needed.

Short term illness: If you experience illness, such as infection, Fever or diarrhea, stop taking Nocdurna (Desmopressin) ODT. You may re-start the medication after the illness has passed.

Low sodium levels: Reduced fluid intake is essential with the use of Nocdurna (Desmopressin). When fluid intake is not reduced enough, fluid retention and possible low levels of sodium in the blood may result. If you experience symptoms of low blood sodium, such as headache, nausea or vomiting, weight gain, or muscle spasms or cramps, contact your doctor as soon as possible. Too little sodium in the body can become dangerous.

Medical conditions: Nocdurna (Desmopressin) is not effective in controlling excessive urination caused by kidney disease, Diabetes, psychosomatic conditions, low blood potassium, or high blood calcium.

Pregnancy: Nocdurna (Desmopressin) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Nocdurna (Desmopressin), contact your doctor immediately.

Breast-feeding: Nocdurna (Desmopressin) may pass into breast milk. If you are a breast-feeding mother and are taking Nocdurna (Desmopressin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Although the effectiveness of other forms of Nocdurna (Desmopressin) have been found to be safe and effective for treating nocturnal enuresis, Nocdurna (Desmopressin) ODT has not been studied for use by children. Nocdurna (Desmopressin) should not be used by children or adolescents less than 18 years of age.

Seniors: People over the age of 65 may be at greater risk of developing low sodium levels.  Your doctor may want to monitor you sodium levels more closely.