Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Nplate (Romiplostim). If you are concerned about side effects, discuss the risks and benefits of Nplate (Romiplostim) with your doctor.

The following side effects have been reported by at least 1% of people taking Nplate (Romiplostim). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Diarrhea
• dizziness
• fatigue
• gas
• headache
• heartburn or indigestion
• joint pain
• muscle pain or weakness
• nausea
• pain in your hands and feet
• shoulder pain
• tingling or numbness of the hands or feet
• trouble sleeping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• bone marrow changes (retiuclin or increased bone marrow fibres) – this finding can only be diagnosed by your doctor with special testing
• rash
• signs of Anemia (low red blood cells; e.g., pale skin, unusual tiredness or weakness)
• signs of bleeding (e.g., nosebleeds, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding, unusual bruising, bloody, black, or tarry stools, or vomiting blood or material that looks like coffee grounds)
• signs of infection (symptoms may include Fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• burning pain, redness, and warmth of the feet and hands
• if you have stopped taking Nplate (Romiplostim) and experience any symptoms related to your ITP condition that you had before starting treatment, including bleeding
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• symptoms of a blood clot (such as headache, tingling in hands or feet, swelling and redness in areas such as the calf)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

250 µg/0.5 mL
Each vial of sterile lyophilized solid white powder contains Nplate (Romiplostim) 375 µg. Nonmedicinal ingredients: dilute hydrochloric acid (for pH adjustment), L-histidine, mannitol, polysorbate 20, and sucrose.

500 µg/1 mL
Each vial of sterile lyophilized solid white powder contains Nplate (Romiplostim) 625 µg. Nonmedicinal ingredients: dilute hydrochloric acid (for pH adjustment), L-histidine, mannitol, polysorbate 20, and sucrose.

Do not use Nplate (Romiplostim) if you:

• are allergic to Nplate (Romiplostim) or any ingredients of Nplate (Romiplostim)
• are allergic to medications made from the bacteria E. coli

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Nplate (Romiplostim).

Bleeding: Serious bleeding can occur while taking Nplate (Romiplostim). Your doctor will monitor you closely by having you take regular blood and lab tests while you are taking Nplate (Romiplostim). If you stop taking Nplate (Romiplostim), your platelet levels may drop, which can put you at risk for serious or life-threatening bleeding. If you experience any signs or symptoms of bleeding (e.g., black and tarry stools, blood in the urine, easy bruising, cuts that won't stop bleeding), contact your doctor immediately.

Blood clots: Nplate (Romiplostim) increases the amount of platelets in your blood to help prevent bleeding. This can also put you at risk of having an unwanted blood clot. If you experience any signs or symptoms of a blood clot (e.g., headache, tingling in hands or feet, swelling and redness in areas such as the calf), contact your doctor immediately.

Blood disorders: If you have blood disorders other than ITP (including blood cancers), discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nplate (Romiplostim), and whether any special monitoring is needed.

Bone marrow: Using Nplate (Romiplostim) for a long period of time may cause changes in your bone marrow, which can lead your body to make abnormal blood cells or fewer blood cells. These signs of bone marrow changes show up in blood tests. Your doctor will monitor you carefully while you are taking Nplate (Romiplostim).

Kidney function: If you have reduced kidney function or Kidney Disease, discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: If you have reduced liver function or liver disease, discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nplate (Romiplostim), and whether any special monitoring is needed.

Pregnancy: Nplate (Romiplostim) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if Nplate (Romiplostim) passes into breast milk. If you are a breast-feeding mother and are taking Nplate (Romiplostim), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Nplate (Romiplostim) have not been established for children.