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Nplate (Romiplostim) belongs to a class of medications called thrombopoiesis-stimulating proteins. Nplate (Romiplostim) is a medication used to treat low platelet levels in people with immune (idiopathic) thrombocytopenic purpura (ITP).
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Nplate (Romiplostim) belongs to a class of medications called thrombopoiesis-stimulating proteins. Nplate (Romiplostim) is a medication used to treat low platelet levels in people with immune (idiopathic) thrombocytopenic purpura (ITP). ITP is a disease where the immune system is confused and attacks the platelet cells in the blood, destroying them.
Platelets are the cells in the blood that form Blood Clots which seal cuts and prevent us from bleeding. Nplate (Romiplostim) stimulates the bone marrow (the part of the bone that makes blood cells) to produce more platelets, which helps to prevent bleeding and bruising. Nplate (Romiplostim) may be used alone or in combination with other medications.
Nplate (Romiplostim) may be available under multiple brand names and/or in several different forms. Any specific brand name of Nplate (Romiplostim) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Nplate (Romiplostim) may not be used for all of the conditions discussed here.
Your doctor may have suggested Nplate (Romiplostim) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Nplate (Romiplostim), speak to your doctor. Do not stop using Nplate (Romiplostim) without consulting your doctor.
Do not give Nplate (Romiplostim) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
The recommended starting dose of Nplate (Romiplostim) is based on body weight and calculated as 1 µg per kilogram of body weight.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
Nplate (Romiplostim) is given as an injection under the skin (subcutaneous) once weekly.
People taking romiplostin will need to have their platelet levels checked regularly. Your doctor will order blood tests to do this. The doctor may adjust the dose of Nplate (Romiplostim) based on these test results to ensure that the proper amount of medication is being given to maintain their platelet levels.
It is important Nplate (Romiplostim) be given exactly as recommended by your doctor. If you miss an appointment to receive Nplate (Romiplostim), contact your doctor as soon as possible to reschedule your appointment.
Nplate (Romiplostim) does not contain preservatives and must be mixed with sterile water for injection before a subcutaneous injection is given. Once the powder has been mixed, it should be used within 24 hours. The mixed powder can remain at room temperature (25°C) or can be refrigerated at 2°C to 8°C for up to 24 hours prior to injection. The mixed powder must be protected from light.
Store Nplate (Romiplostim) in the refrigerator at 2°C to 8°C (do not freeze), protect it from light, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Nplate (Romiplostim). If you are concerned about side effects, discuss the risks and benefits of Nplate (Romiplostim) with your doctor.
The following side effects have been reported by at least 1% of people taking Nplate (Romiplostim). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
250 µg/0.5 mL
Each vial of sterile lyophilized solid white powder contains Nplate (Romiplostim) 375 µg. Nonmedicinal ingredients: dilute hydrochloric acid (for pH adjustment), L-histidine, mannitol, polysorbate 20, and sucrose.
500 µg/1 mL
Each vial of sterile lyophilized solid white powder contains Nplate (Romiplostim) 625 µg. Nonmedicinal ingredients: dilute hydrochloric acid (for pH adjustment), L-histidine, mannitol, polysorbate 20, and sucrose.
Do not use Nplate (Romiplostim) if you:
Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Nplate (Romiplostim).
Bleeding: Serious bleeding can occur while taking Nplate (Romiplostim). Your doctor will monitor you closely by having you take regular blood and lab tests while you are taking Nplate (Romiplostim). If you stop taking Nplate (Romiplostim), your platelet levels may drop, which can put you at risk for serious or life-threatening bleeding. If you experience any signs or symptoms of bleeding (e.g., black and tarry stools, blood in the urine, easy bruising, cuts that won't stop bleeding), contact your doctor immediately.
Blood clots: Nplate (Romiplostim) increases the amount of platelets in your blood to help prevent bleeding. This can also put you at risk of having an unwanted blood clot. If you experience any signs or symptoms of a blood clot (e.g., headache, tingling in hands or feet, swelling and redness in areas such as the calf), contact your doctor immediately.
Blood disorders: If you have blood disorders other than ITP (including blood cancers), discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nplate (Romiplostim), and whether any special monitoring is needed.
Bone marrow: Using Nplate (Romiplostim) for a long period of time may cause changes in your bone marrow, which can lead your body to make abnormal blood cells or fewer blood cells. These signs of bone marrow changes show up in blood tests. Your doctor will monitor you carefully while you are taking Nplate (Romiplostim).
Kidney function: If you have reduced kidney function or Kidney Disease, discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: If you have reduced liver function or liver disease, discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nplate (Romiplostim), and whether any special monitoring is needed.
Pregnancy: Nplate (Romiplostim) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if Nplate (Romiplostim) passes into breast milk. If you are a breast-feeding mother and are taking Nplate (Romiplostim), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Nplate (Romiplostim) have not been established for children.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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