Pentoxifylline belongs to the group of medications called vasoactive agents. These medications work by improving blood flow in the arms and legs. Pentoxifylline is used to treat chronic circulation disorders of the arms and legs, such as intermittent claudication (peripheral arterial disease) or ulcers due to poor blood supply. It may allow further distances to be walked before leg pain or cramps occur. It may take up to 2 months to see the full benefits of the medication.

Your doctor may have suggested Pentoxifylline Sr for conditions other than those listed in these drug information articles. As well, some forms of Pentoxifylline Sr may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking Pentoxifylline Sr, speak to your doctor. Do not stop taking Pentoxifylline Sr without consulting your doctor.

Do not give Pentoxifylline Sr to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Pentoxifylline Sr if their doctor has not prescribed it.

The usual recommended adult starting dose of pentoxifylline is 400 mg twice daily after meals. Your doctor may adjust the dose over time as needed to a maximum of 400 mg 3 times daily. The tablets must be swallowed whole - do not crush or chew the tablets.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Pentoxifylline Sr exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Pentoxifylline Sr at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Pentoxifylline Sr. If you are concerned about side effects, discuss the risks and benefits of Pentoxifylline Sr with your doctor.

The following side effects have been reported by at least 1% of people taking Pentoxifylline Sr. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• bloating
• Diarrhea
• dizziness or lightheadedness
• flushing
• general feeling of discomfort or feeling unwell
• headache
• heartburn
• nausea
• stomach discomfort
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• irregular heartbeat

Stop taking the medication and seek immediate medical attention if any of the following occur:

• bleeding (blood in your stool or bleeding around your eyes)
• chest pain
• difficulty breathing
• symptoms of an allergic reaction, e.g.:
  • blisters
  • itching
  • red spots
  • swelling

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Pentoxifylline Sr.

Each bright pink, capsule-shaped, film-coated, sustained-release tablet, identified "APO" on one side and "400" on the other, contains pentoxifylline 400 mg. Nonmedicinal ingredients: carnauba wax, colloidal silicon dioxide, erythrosine lake (FD&C Red No. 3), hydroxypropyl methylcellulose, magnesium stearate, Polyethylene Glycol 3350 (carbowax), and titanium dioxide.

Do not take pentoxifylline if you:

• are allergic to pentoxifylline, to the class of medications called xanthines (e.g., caffeine, Theophylline, and theobromine), or to any of the ingredients of the medication
• are bleeding or at risk of increased bleeding
• are having a Heart Attack
• have severe Coronary Artery Disease and, in the doctor's judgment, stimulation of the heart could prove harmful
• have or have recently had a stomach or intestinal ulcer

There may be an interaction between pentoxifylline and any of the following:

• antidiabetes medications (e.g., Glyburide, insulin, Metformin)
• blood pressure reducing medications (e.g., Metoprolol, Ramipril)
• Cimetidine
• ciprofloxacin
• erythromycin
• Ketorolac medications that affect blood clotting (e.g., Clopidogrel, Heparin, warfarin)
• sympathomimetic medications (e.g., Pseudoephedrine)
• theophylline

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Pentoxifylline Sr. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.