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Replagal

Replagal

Agalsidase-alfa

Agalsidase alfa belongs to the group of medications known as enzyme replacement therapy. It is used as enzyme replacement therapy for people with Fabry disease.

Available form

Injectable

Dosage

1mg/ml

Manufacturers

Takeda

Generic brand of

Agalsidase-alfa

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Replagal information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Currently, the usual dose of agalsidase alfa is 0.2 mg per kilogram of body weight given every 2 weeks as an infusion into a vein. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important that Replagal (Agalsidase-alfa) be given exactly as recommended by your doctor. If you miss an appointment to receive agalsidase alfa, contact your doctor as soon as possible to reschedule your appointment. If you are receiving Replagal (Agalsidase-alfa) at home and miss a dose, contact your doctor.

Vials of Replagal (Agalsidase-alfa) should be stored in the refrigerator. Keep Replagal (Agalsidase-alfa) out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Replagal (Agalsidase-alfa). If you are concerned about side effects, discuss the risks and benefits of Replagal (Agalsidase-alfa) with your doctor.

The following side effects have been reported by at least 1% of people taking Replagal (Agalsidase-alfa). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal discomfort
Acne
change in taste of food
changed sensitivity to touch
decreased sense of smell
Diarrhea
dry skin
eye problems
fatigue
flushing
headache
heartburn
increased blood pressure
increased tear production
nausea
numbness
"pins and needles" feeling in arms or legs
tremors
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

dizziness or lightheadedness
fast heartbeat
Fever
infusion-related reactions (chills, fever, feeling hot or cold, high blood pressure, nausea, vomiting, flushing, burning sensation, fatigue, pain, headache, chest pain, itchy skin)
pain or tenderness in chest, muscles, or joints
puffiness around eyes
sensation of spinning
shortness of breath
skin rash or itching
swelling of the legs, feet, or hands
symptoms of an infection (cough, runny nose, sore throat)

Stop taking the medication and seek immediate medical attention if any of the following occur:

symptoms of a serious allergic reaction (e.g., shortness of breath; difficulty breathing; wheezing; Hives; swelling of the face, lips, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Replagal (Agalsidase-alfa).

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All material © 1996-2025 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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