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Available Form:   Injectable
Manufacturer name:   Shire
Generic name:   agalsidase-alfa
Strength:   1mg/ml

What is Replagal?

Agalsidase alfa belongs to the group of medications known as enzyme replacement therapy. It is used as enzyme replacement therapy for people with Fabry disease.

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Replagal frequently asked questions

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Replagal in Canada?

Shipping cost for Replagal to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Replagal delivered to my home?

You could get Replagal delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Replagal in Canada for free?

You can get Replagal for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Replagal for free.

Replagal How to Take

Agalsidase alfa belongs to the group of medications known as enzyme replacement therapy. It is used as enzyme replacement therapy for people with Fabry disease. Fabry disease is a genetic disorder where the level of alfa-galactosidase (an enzyme that breaks down fats) is low or absent. With Fabry disease globotriaosylceramide or GL-3, a fat substance, is not removed from cells in the body and starts to accumulate in the walls of blood vessels and organs. By reducing GL-3 levels in the body, agalsidase alfa slows the rate of progression of Fabry disease in the kidney, heart and brain.

Agalsidase alfa has been granted a notice of compliance with conditions (NOC/c) by Health Canada. Health Canada has approved Replagal (Agalsidase-alfa) to be marketed based on promising evidence of effectiveness but that additional are needed to verify optimal individual dosing. An NOC/c is used to allow access to products that are used for the treatment or prevention of serious, life-threatening or severely debilitating illness.

Your doctor may have suggested Replagal (Agalsidase-alfa) for conditions other than those listed in these drug information articles. As well, some forms of Replagal (Agalsidase-alfa) may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are using Replagal (Agalsidase-alfa), speak to your doctor. Do not stop using Replagal (Agalsidase-alfa) without consulting your doctor.

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Replagal Dosage

Currently, the usual dose of agalsidase alfa is 0.2 mg per kilogram of body weight given every 2 weeks as an infusion into a vein.  Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important that Replagal (Agalsidase-alfa) be given exactly as recommended by your doctor. If you miss an appointment to receive agalsidase alfa, contact your doctor as soon as possible to reschedule your appointment. If you are receiving Replagal (Agalsidase-alfa) at home and miss a dose, contact your doctor.

Vials of Replagal (Agalsidase-alfa) should be stored in the refrigerator.  Keep Replagal (Agalsidase-alfa) out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Replagal Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Replagal (Agalsidase-alfa). If you are concerned about side effects, discuss the risks and benefits of Replagal (Agalsidase-alfa) with your doctor.

The following side effects have been reported by at least 1% of people taking Replagal (Agalsidase-alfa). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal discomfort
  • Acne
  • change in taste of food
  • changed sensitivity to touch
  • decreased sense of smell
  • Diarrhea
  • dry skin
  • eye problems
  • fatigue
  • flushing
  • headache
  • heartburn
  • increased blood pressure
  • increased tear production
  • nausea
  • numbness
  • "pins and needles" feeling in arms or legs
  • tremors
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • dizziness or lightheadedness
  • fast heartbeat
  • Fever
  • infusion-related reactions (chills, fever, feeling hot or cold, high blood pressure, nausea, vomiting, flushing, burning sensation, fatigue, pain, headache, chest pain, itchy skin)
  • pain or tenderness in chest, muscles, or joints
  • puffiness around eyes
  • sensation of spinning
  • shortness of breath
  • skin rash or itching
  • swelling of the legs, feet, or hands
  • symptoms of an infection (cough, runny nose, sore throat)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of a serious allergic reaction (e.g., shortness of breath; difficulty breathing; wheezing; Hives; swelling of the face, lips, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Replagal (Agalsidase-alfa).

Automatic Refills

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Replagal Available Form

Each mL of concentrated solution for infusion contains 3.5 mg of agalsidase alfa. Nonmedicinal ingredients: polysorbate 20, sodium chloride, sodium hydroxide, sodium phosphate monobasic monohydrate, and water for injection.

Replagal Contraindications

Do not use agalsidase alfa if you:

  • are allergic to agalsidase alfa or any ingredients of the medication

Discreet Packaging

Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.

Replagal Precautions

There may be an interaction between agalsidase alfa and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Replagal (Agalsidase-alfa). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Replagal Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Replagal (Agalsidase-alfa).

Allergic and infusion-related reactions: Replagal (Agalsidase-alfa) can cause allergic reactions, some of which can be severe. You will receive Replagal (Agalsidase-alfa) under close medical supervision, especially at the beginning of treatment.

Most people develop antibodies when treated with enzyme replacement therapy. If you develop antibodies to agalsidase alfa, you might experience allergic side effects such as an infusion-related reaction. The antibodies are not likely to stop Replagal (Agalsidase-alfa) from working and will decrease with time. Infusion-related reactions can include chills and fever and usually start within the first 2 to 4 months of treatment.

If you experience an infusion-related reaction, your doctor can decrease the infusion rate or treat the reaction with other medications (e.g., Acetaminophen, Ibuprofen, antihistamines, or corticosteroids).

Pregnancy: Replagal (Agalsidase-alfa) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Replagal (Agalsidase-alfa), contact your doctor immediately.

Breast-feeding: It is not known if agalsidase alfa passes into breast milk. If you are a breast-feeding mother and are taking Replagal (Agalsidase-alfa), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Replagal (Agalsidase-alfa) have not been studied in children under the age of 7 years.

Seniors: The safety and effectiveness of using Replagal (Agalsidase-alfa) have not been established for seniors.

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All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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