Trimebutine belongs to the class of medications called spasmolytics. It is used to treat irritable bowel syndrome (spastic colon). This condition is caused by overactive movements of the bowels. Trimebutine works by slowing down or normalizing the abnormal movements of the bowel.

Your doctor may have suggested Trimebutine for conditions other than those listed in these drug information articles. As well, some forms of Trimebutine may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking Trimebutine, speak to your doctor. Do not stop taking Trimebutine without consulting your doctor.

Do not give Trimebutine to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Trimebutine if their doctor has not prescribed it.

The adult recommended dose consists of up to 600 mg daily taken in 3 divided doses (200 mg 3 times daily) before meals.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Trimebutine exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Trimebutine at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Trimebutine. If you are concerned about side effects, discuss the risks and benefits of Trimebutine with your doctor.

The following side effects have been reported by at least 1% of people taking Trimebutine. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Constipation
• Diarrhea
• dizziness
• drowsiness
• Dry Mouth
• fatigue
• foul taste
• Headaches
• hot or cold sensations
• indigestion
• nausea
• rash

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Trimebutine.

100 mg
Each white, round, biconvex tablet, scored, and engraved "TMB" over "100" on one side contains 100 mg of trimebutine maleate. Nonmedicinal ingredients: magnesium stearate and methylcellulose.

200 mg
Each white, round, biconvex tablet, scored, and engraved "TMB" over "200" on one side contains 200 mg of trimebutine maleate. Nonmedicinal ingredients: magnesium stearate and methylcellulose.

Trimebutine should not be taken by anyone who is allergic to trimebutine or to any of the ingredients of the medication.

There may be an interaction between trimebutine and any of the following:

• tubocurarine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Trimebutine. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Trimebutine.

Pregnancy: The use of trimebutine by pregnant women is not recommended. If you become pregnant while taking Trimebutine, contact your doctor immediately.

Breast-feeding: It is not known if trimebutine passes into breast milk. If you are a breast-feeding mother and are taking Trimebutine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Trimebutine is not recommended for use by children under 12 years of age.