Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Typherix (Typhoid-vaccine-inactivated). If you are concerned about side effects, discuss the risks and benefits of Typherix (Typhoid-vaccine-inactivated) with your doctor.

The following side effects have been reported by at least 1% of people taking Typherix (Typhoid-vaccine-inactivated). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Diarrhea
• fever
• general body ache or discomfort
• headache
• itching
• muscle ache
• nausea
• soreness, pain, redness, or swelling at the injection site

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (such as abdominal cramps, difficulty breathing, nausea and vomiting, swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Typherix (Typhoid-vaccine-inactivated).

Each 0.5 mL dose of clear, colourless liquid for intramuscular injection contains Salmonella typhi (TY2 strain) Vi polysaccharide 25 µg. Nonmedicinal ingredients: sodium chloride, disodium phosphate dihydrate, sodium dihydrogen phosphate dehydrate, phenol, and water for injection.

Do not take Typherix (Typhoid-vaccine-inactivated) if you:

• are allergic to typhoid vaccine or any ingredients of the medication
• have a fever or severe illness at the time of vaccination

There may be an interaction between typhoid vaccine and any of the following:

• antineoplastic or chemotherapy medications
• corticosteroids (e.g., Dexamethasone, Prednisone)
• immunosuppressants (e.g., Azathioprine, Cyclosporine, Fingolimod, hydroxychloroquine, Leflunomide, Tacrolimus)
• other live vaccines

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Typherix (Typhoid-vaccine-inactivated). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Typherix (Typhoid-vaccine-inactivated).

Allergic reactions: Rarely, this vaccine may cause severe allergic reactions. If you notice the signs of a Anaphylaxis (severe allergic reaction) (Hives; trouble breathing or swallowing; or swelling of the lips, face, throat, or tongue) get medical attention immediately.

Bleeding problems: If you have blood clotting problems or are currently taking blood thinners (oral anticoagulants), notify your doctor prior to injection.

Immunocompromised people: Typhoid vaccine may not be as effective for people with a compromised immune system (e.g., people with AIDS, people receiving chemotherapy, or people taking any medication that suppresses the immune system). People with any of these conditions should discuss with their doctor how Typherix (Typhoid-vaccine-inactivated) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Typherix (Typhoid-vaccine-inactivated), and whether any special monitoring is needed.

Infection and fever: Delay receiving the typhoid vaccine if you have an infection or fever, unless, in the opinion of your doctor, the benefits of receiving the vaccine while you are ill outweigh the risks.

Protection against typhoid: Not all people who take the vaccine will be fully protected against typhoid. This is especially so if the vaccine is given less than 2 weeks before arriving in the areas with typhoid exposure risk.

Pregnancy: The effects of Typherix (Typhoid-vaccine-inactivated) on an unborn baby are not known. Typherix (Typhoid-vaccine-inactivated) should not be used during pregnancy unless the benefits outweigh the risks. If you are or may be pregnant, discuss the risks and benefits of using this vaccine with your doctor.

Breast feeding: It is not known if typhoid vaccine passes into breast milk. If you are a breast-feeding mother and are taking Typherix (Typhoid-vaccine-inactivated), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Typherix (Typhoid-vaccine-inactivated) have not been established for children under 2 years of age.