Vectibix 100 (Panitumumab) belongs to the group of cancer-fighting medications known as antineoplastics. It is a monoclonal antibody that recognizes and attaches to certain types of cancer cells. This may prevent cancer cells from growing and dividing. Vectibix 100 (Panitumumab) is used in combination with other medications to treat a certain type of colorectal cancer that has spread to other parts of the body (metastatic colorectal cancer) and has not been treated with other medications. It is also used alone to treat metastatic colorectal cancer that has not responded to other specific anticancer medications.

Vectibix 100 (Panitumumab) may be available under multiple brand names and/or in several different forms. Any specific brand name of Vectibix 100 (Panitumumab) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Vectibix 100 (Panitumumab) may not be used for all of the conditions discussed here.

Your doctor may have suggested Vectibix 100 (Panitumumab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Vectibix 100 (Panitumumab), speak to your doctor. Do not stop using Vectibix 100 (Panitumumab) without consulting your doctor.

Do not give Vectibix 100 (Panitumumab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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The usual recommended dose of Vectibix 100 (Panitumumab) is 6 mg per kilogram of body weight given as an infusion into a vein every 2 weeks. If you experience certain side effects or do not tolerate Vectibix 100 (Panitumumab), your doctor may temporarily stop Vectibix 100 (Panitumumab), restart it at a lower dose, and then gradually increase the dose until the recommended dose is reached.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.

Very careful handling of Vectibix 100 (Panitumumab) is required. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

It is important to receive Vectibix 100 (Panitumumab) within 3 days before or 3 days after each scheduled dose (except if your dose is adjusted because of side effects). If you miss an appointment to receive Vectibix 100 (Panitumumab), contact your doctor as soon as possible to reschedule your appointment.

This medication is stored in the refrigerator and should be protected from light. Do not shake Vectibix 100 (Panitumumab) or allow it to freeze.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses.

Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Vectibix 100 (Panitumumab). If you are concerned about side effects, discuss the risks and benefits of Vectibix 100 (Panitumumab) with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Diarrhea (mild and not associated with other symptoms)
• fatigue
• mouth sores or ulcers
• nausea
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• cracked, dry or itchy skin
• diarrhea (more than one day along with Fever, decreased urination, dizziness, or a fast heartbeat)
• eye problems (e.g., itchy, dry, irritated eyes, increased tear production, vision changes)
• irritation, redness of swelling of tongue or lips
• nail infection (swelling and inflammation around the finger nails and toe nails)
• painful swollen skin
• peeling or red raised skin
• signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
• signs of kidney problems (e.g., decreased urination, nausea, vomiting, swelling of the feet and ankles)
• signs of low blood calcium levels (e.g., muscle spasms, tingling or numbness of the fingers and mouth, twitching, or memory loss)
• signs of low potassium levels in the blood (e.g., weakness, fatigue, muscle cramps, irregular heartbeat)
• symptoms of lung problems (e.g., difficulty breathing, shortness of breath, wheezing)
• skin fissures
• skin infection (warmth, swelling, redness)
• symptoms of an infusion reaction (fever, chills, shortness of breath, swelling of the face, rash, dizziness, increased heart rate, sweating)
• symptoms of low magnesium levels in the blood (severe weakness and fatigue)
• skin rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

• symptoms of a blood clot in the lung (severe shortness of breath, coughing up blood, sudden chest pain)
• symptoms of an allergic reaction (difficulty breathing, sweating, swelling of the face or throat, Hives)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Vectibix 100 (Panitumumab).

Automatic Refills

We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.

Each mL of sterile, colourless solution contains 20 mg of Vectibix 100 (Panitumumab). Nonmedicinal ingredients: sodium acetate USP, sodium chloride USP, and water for injection USP. Preservative-free.

Do not use Vectibix 100 (Panitumumab) if you are allergic to Vectibix 100 (Panitumumab) or to any of the ingredients of the medication.

Personalized PocketPacks

We sort your medication into clearly labeled, individual packs so you can be sure you're taking the right dose at the right time.

There may be an interaction between Vectibix 100 (Panitumumab) and any of the following:

• other chemotherapy medications
• Porfimer
• vertiporfin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reactions: Vectibix 100 (Panitumumab) can cause allergic reactions and side effects that are related to receiving the infusion. Some of these reactions can be severe. If you experience shortness of breath, wheezing, fever, chills, lightheadedness, dizziness, or swelling of the face and throat, tell your doctor immediately or get immediate medical attention.

Diarrhea: Vectibix 100 (Panitumumab) can cause diarrhea that can lead to dehydration (loss of too much water from the body). If you experience severe diarrhea for more than a day, or if you have diarrhea along with fever, decreased urination, dizziness, or a fast heartbeat, contact your doctor immediately.

Fluid and electrolyte balance: Vectibix 100 (Panitumumab) may cause the levels of electrolytes such as potassium, sodium, magnesium, chloride, and calcium in the blood to change while taking Vectibix 100 (Panitumumab). If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; Dry Mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible. Your doctor will do blood tests regularly to monitor the levels of these electrolytes in your blood while you are taking Vectibix 100 (Panitumumab).

Infusion reactions: Vectibix 100 (Panitumumab) can cause a hypersensitivity or infusion reaction. Symptoms of this type of reaction generally appear during the infusion of the medication and may include flushing, chest pain, shortness of breath, and a dramatic drop in blood pressure. These reactions can cause death if a health care provider is not informed immediately. If you experience any of these symptoms, or notice them happening to someone, let your nurse or doctor know immediately.

Kidney function: Vectibix 100 (Panitumumab) can cause decreased kidney function or kidney failure, especially for people who are experiencing dehydration, which can occur with severe diarrhea. If you experience puffy hands, face or feet, high blood pressure, unusual muscle cramping, or darkened urine, this medication may be affecting how well your kidneys are working. If you notice any of these symptoms, contact your doctor as soon as possible

The safety and effectiveness of using Vectibix 100 (Panitumumab) have not been established for people with kidney problems. If you have decreased kidney function or Kidney Disease, discuss with your doctor how Vectibix 100 (Panitumumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: The safety and effectiveness of using Vectibix 100 (Panitumumab) have not been established for people with liver problems. If you have liver disease or decreased liver function, discuss with your doctor how Vectibix 100 (Panitumumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Vectibix 100 (Panitumumab), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Vectibix 100 (Panitumumab).

Lung problems: Vectibix 100 (Panitumumab) and similar medications can cause lung problems. If you experience difficulty breathing or shortness of breath while you are taking Vectibix 100 (Panitumumab), contact your doctor immediately.

If you have or have had interstitial pneumonitis (swelling of the lungs causing cough and difficulty breathing) or Pulmonary Fibrosis (scarring and thickening in the lungs with shortness of breath), discuss with your doctor how Vectibix 100 (Panitumumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Vectibix 100 (Panitumumab), and whether any special monitoring is needed.

Skin reactions: Vectibix 100 (Panitumumab) commonly causes skin reactions. Some of these reactions can be severe. If you experience skin redness, itching, rash, peeling, cracks, dryness, or swelling and inflammation around the nails, contact your doctor. Since sunlight may worsen skin reactions caused by this medication, people taking it should wear sunscreen and a hat, and limit sun exposure.

Pregnancy: Vectibix 100 (Panitumumab) should not be used during pregnancy. Women who could become pregnant should use effective contraception while receiving Vectibix 100 (Panitumumab) and for 6 months after stopping it. If you become pregnant while taking Vectibix 100 (Panitumumab), contact your doctor immediately.

Breast-feeding: It is not known if Vectibix 100 (Panitumumab) passes into breast milk. If you are a breast-feeding mother and are taking Vectibix 100 (Panitumumab), it may affect your baby. If you are taking Vectibix 100 (Panitumumab), you should not breast-feed during treatment and for 2 months after the last dose.

Children: The safety and effectiveness of using Vectibix 100 (Panitumumab) have not been established for children less than 18 years of age.

Seniors: People over the age of 65 years may be more at risk of side effects from this medication.

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