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Botulinum toxin is a neuromuscular paralytic agent. It blocks the nerves that are responsible for muscle activity and helps to relax muscles that are in constant contraction (spasm).
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Botulinum toxin is a neuromuscular paralytic agent. It blocks the nerves that are responsible for muscle activity and helps to relax muscles that are in constant contraction (spasm). It is used to treat conditions that are caused by certain muscles going into spasm. These include:
Botox (Onabotulinumtoxin-a) may be available under multiple brand names and/or in several different forms. Any specific brand name of Botox (Onabotulinumtoxin-a) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Botox (Onabotulinumtoxin-a) may not be used for all of the conditions discussed here.
Your doctor may have suggested Botox (Onabotulinumtoxin-a) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Botox (Onabotulinumtoxin-a), speak to your doctor. Do not stop receiving Botox (Onabotulinumtoxin-a) without consulting your doctor.
Botulinum toxin is injected into a muscle (or under the skin when used for excessive underarm sweating) by a qualified health professional. When given for conditions of the eye, the medication is injected into the surrounding muscle or tissue of the eye.
The dose of medication required depends on the condition being treated and individual circumstances. More than one dose may be required, depending on the condition being treated. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications.
It is important Botox (Onabotulinumtoxin-a) be given exactly as recommended by your doctor. If you miss an appointment to receive botulinum toxin type A, contact your doctor as soon as possible to reschedule your appointment. It is very important to keep your appointments for treatment and follow-up.
The dried product should be stored in a refrigerator at 2°C to 8°C, or in a freezer at or below -5°C. The dried product should be diluted with the supplied solution after it is removed from the freezer and kept in the refrigerator until use or up to 24 hours. Botox (Onabotulinumtoxin-a) should be kept out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Botox (Onabotulinumtoxin-a). If you are concerned about side effects, discuss the risks and benefits of Botox (Onabotulinumtoxin-a) with your doctor.
The following side effects have been reported by at least 1% of people taking Botox (Onabotulinumtoxin-a). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
General side effects:
When used for blepharospasm:
When used for cervical dystonia:
When used for focal spasticity:
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Botox (Onabotulinumtoxin-a).
This product is available in sterile vials containing 50, 100, or 200 Allergan units of Clostridium botulinum toxin type A. Nonmedicinal ingredients: human serum Albumin and sodium chloride. This product contains no preservative.
Do not take botulinum toxin if you:
There may be an interaction between botulinum toxin type A and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Botox (Onabotulinumtoxin-a). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Botox (Onabotulinumtoxin-a).
Angle-closure Glaucoma: Botulinum toxin can cause angle-closure glaucoma in those at risk. Your doctor will monitor for this if necessary. If you have glaucoma, discuss with your doctor how Botox (Onabotulinumtoxin-a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Botox (Onabotulinumtoxin-a), and whether any special monitoring is needed.
Distant toxin spread: Very rarely, Botox (Onabotulinumtoxin-a) may spread to other parts of the body other than where it was injected, leading to muscle weakness, difficulty swallowing, pneumonia, speech difficulties, and breathing problems. Distant toxin spread can be fatal. If you develop severe difficulty swallowing, speaking, or breathing while using Botox (Onabotulinumtoxin-a), contact your doctor immediately.
Heart disease: Botulinum toxin has rarely been reported to cause arrhythmia and heart attack. People with heart conditions may be at increased risk of irregular heartbeat or heart attack. If you have a heart condition, discuss with your doctor how Botox (Onabotulinumtoxin-a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Botox (Onabotulinumtoxin-a), and whether any special monitoring is needed.
Other medical conditions: People with certain nerve or muscle disorders are at increased risk of developing serious side effects, such as difficulty swallowing or breathing. If you have amyotrophic lateral sclerosis, any disorder that produces a depletion of acetylcholine, or disorders that produce peripheral neuromuscular dysfunction, discuss with your doctor how Botox (Onabotulinumtoxin-a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Botox (Onabotulinumtoxin-a), and whether any special monitoring is needed.
Pregnancy: Botox (Onabotulinumtoxin-a) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while receiving Botox (Onabotulinumtoxin-a), contact your doctor immediately.
Breast-feeding: It is not known if botulinum toxin passes into breast milk. If you are a breast-feeding mother and are receiving Botox (Onabotulinumtoxin-a), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this have not been established for children under 18 years of age.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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