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Botox

Botox

Onabotulinumtoxin-a

Botulinum toxin is a neuromuscular paralytic agent. It blocks the nerves that are responsible for muscle activity and helps to relax muscles that are in constant contraction (spasm).

Available form

Powder

Dosage

50IU, 100IU, 200IU

Manufacturers

Abbvie Corporation, Allergan

Generic brand of

Onabotulinumtoxin-a

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Botox information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Botulinum toxin is injected into a muscle (or under the skin when used for excessive underarm sweating) by a qualified health professional. When given for conditions of the eye, the medication is injected into the surrounding muscle or tissue of the eye.

The dose of medication required depends on the condition being treated and individual circumstances. More than one dose may be required, depending on the condition being treated. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications.

It is important Botox (Onabotulinumtoxin-a) be given exactly as recommended by your doctor. If you miss an appointment to receive botulinum toxin type A, contact your doctor as soon as possible to reschedule your appointment. It is very important to keep your appointments for treatment and follow-up.

The dried product should be stored in a refrigerator at 2°C to 8°C, or in a freezer at or below -5°C. The dried product should be diluted with the supplied solution after it is removed from the freezer and kept in the refrigerator until use or up to 24 hours. Botox (Onabotulinumtoxin-a) should be kept out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Botox (Onabotulinumtoxin-a). If you are concerned about side effects, discuss the risks and benefits of Botox (Onabotulinumtoxin-a) with your doctor.

The following side effects have been reported by at least 1% of people taking Botox (Onabotulinumtoxin-a). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

General side effects:

pain, tenderness, or bruising at the place of injection

When used for blepharospasm:

drooping of the upper eyelid
double vision
dry eye
irritation or watering of the eye
not able to close the eye completely
sensitivity of the eye to light
swelling of the eyelid

When used for cervical dystonia:

flu symptoms
local or general weakness
nausea
neck weakness

When used for focal spasticity:

decreased coordination
feeling of "pins and needles"
Fever
flu symptoms
headache
increased sensitivity to touch
itching
joint pain
muscle tightness or weakness
nausea
pain in the affected limb (arm or leg)

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

difficult or painful swallowing, dizziness, shortness of breath, or vision changes (when used for cervical dystonia)
facial paralysis or persistent eye irritation or pain (when used for eye conditions)
falling (when used for spasticity due to cerebral palsy)
fever, especially when accompanied by coughing and shortness of breath
irregular heartbeat
shortness of breath
skin rash
symptoms of a urinary tract infection (e.g. pain when urinating, urinating more often than usual, low back or flank pain)

Stop taking the medication and seek immediate medical attention if any of the following occur:

breathing problems
difficulty swallowing
muscle weakness
peeling or blistering skin
seizures
signs of an allergic reaction (e.g., Hives; difficulty breathing; swelling of the mouth, tongue, or throat)
signs of a Heart Attack (e.g., chest pain or pressure; shortness of breath; jaw, shoulder, or arm pain; nausea; lightheadedness; sweating)
speech problems

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Botox (Onabotulinumtoxin-a).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Botox (Onabotulinumtoxin-a).

Angle-closure Glaucoma: Botulinum toxin can cause angle-closure glaucoma in those at risk. Your doctor will monitor for this if necessary. If you have glaucoma, discuss with your doctor how Botox (Onabotulinumtoxin-a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Botox (Onabotulinumtoxin-a), and whether any special monitoring is needed.

Distant toxin spread: Very rarely, Botox (Onabotulinumtoxin-a) may spread to other parts of the body other than where it was injected, leading to muscle weakness, difficulty swallowing, pneumonia, speech difficulties, and breathing problems. Distant toxin spread can be fatal. If you develop severe difficulty swallowing, speaking, or breathing while using Botox (Onabotulinumtoxin-a), contact your doctor immediately.

Heart disease: Botulinum toxin has rarely been reported to cause arrhythmia and heart attack. People with heart conditions may be at increased risk of irregular heartbeat or heart attack. If you have a heart condition, discuss with your doctor how Botox (Onabotulinumtoxin-a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Botox (Onabotulinumtoxin-a), and whether any special monitoring is needed.

Other medical conditions: People with certain nerve or muscle disorders are at increased risk of developing serious side effects, such as difficulty swallowing or breathing. If you have amyotrophic lateral sclerosis, any disorder that produces a depletion of acetylcholine, or disorders that produce peripheral neuromuscular dysfunction, discuss with your doctor how Botox (Onabotulinumtoxin-a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Botox (Onabotulinumtoxin-a), and whether any special monitoring is needed.

Pregnancy: Botox (Onabotulinumtoxin-a) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while receiving Botox (Onabotulinumtoxin-a), contact your doctor immediately.

Breast-feeding: It is not known if botulinum toxin passes into breast milk. If you are a breast-feeding mother and are receiving Botox (Onabotulinumtoxin-a), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this have not been established for children under 18 years of age.

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All material © 1996-2025 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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