Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Flonase (Fluticasone-propionate-nasal). If you are concerned about side effects, discuss the risks and benefits of Flonase (Fluticasone-propionate-nasal) with your doctor.

The following side effects have been reported by at least 1% of people taking Flonase (Fluticasone-propionate-nasal). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• burning, dryness, or other irritation inside the nose
• change in sense of taste or smell
• cough
• headache
• hoarseness
• nasal congestion
• runny nose
• sneezing after using the spray
• sore throat

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• bloody nasal mucus
• eye problems (eye pain, blurred vision)
• getting infections more often than usual; cold or flu-like symptoms
• mood changes (e.g., irritability, aggression, anxiety)
• nasal septum perforation (small holes in the wall between the nostrils)
• pain in arms, back, hips, legs, ribs, or shoulders
• severe, unexplained nosebleeds
• signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• slowed growth in children and adolescents
• slowed wound healing
• sores or ulcers inside the nose or mouth
• symptoms of decreased adrenal function (e.g., tiredness, weakness, nausea, vomiting, Low Blood Pressure)
• symptoms of a fungal infection in the nose (e.g., nasal discharge, fever, headache, fatigue, generally not feeling well)
• symptoms of too much corticosteroid (e.g., weight gain especially around the body and face, "moon face," sweating, thinning of the skin, easy bruising, muscle and bone weakness)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (sudden wheezing or difficulty breathing, chest pain or tightness; Hives; swelling of the face, lips, or eyes)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Flonase (Fluticasone-propionate-nasal).

Each 100 mg of spray (1 spray) delivered by the nasal adaptor contains 50 µg of fluticasone. Nonmedicinal ingredients: benzalkonium chloride, dextrose, microcrystalline cellulose and carboxymethylcellulose sodium, phenylethyl alcohol, polysorbate 80, and purified water.

Fluticasone propionate nasal spray should not be used by anyone who:

• is allergic to fluticasone or to any of the ingredients of the medication
• has untreated fungal, bacterial, or Tuberculosis infections of the respiratory tract

There may an interaction between fluticasone propionate nasal spray and any of the following:

• Aspirin
• "azole" antifungals (e.g., ketoconazole, itraconazole, Voriconazole)
• boceprevir
• Ceritinib
• Cobicistat
• conivaptan
• delaviridine
• Desmopressin
• HIV protease inhibitors (atazanavir, darunavir, lopinavir, ritonavir, tipranavir)
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• nefazodone
• ritonavir
• telaprevir

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Flonase (Fluticasone-propionate-nasal). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Flonase (Fluticasone-propionate-nasal).

Additional medication: Although fluticasone propionate will control seasonal allergic rhinitis in most cases, an abnormally heavy amount of summer pollen may sometimes require additional treatment, particularly to control eye symptoms. Speak to your doctor if you have been using Flonase (Fluticasone-propionate-nasal) for 3 weeks and are still experiencing allergic rhinitis symptoms.

Growth in children and adolescents: Corticosteroids such as fluticasone propionate nasal spray may impair the growth of children and adolescents. Your doctor will monitor for this. Talk to your doctor if you have any concerns.

Infections: Corticosteroids such as fluticasone propionate nasal spray may worsen existing infections, mask the signs of infection, and cause new infections. If you use Flonase (Fluticasone-propionate-nasal) for several months or longer, your doctor will monitor you periodically for signs of infection. People who have not had Chickenpox or Measles or have not been vaccinated against these infections should take special care to avoid exposure to them.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Flonase (Fluticasone-propionate-nasal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Flonase (Fluticasone-propionate-nasal), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Flonase (Fluticasone-propionate-nasal).

Stopping treatment: Under most circumstances, treatment with corticosteroids such as fluticasone propionate nasal spray should be tapered off gradually and not stopped suddenly. In the case of fluticasone propionate nasal spray, this is usually only a concern at high doses. Talk with your doctor if you have questions about stopping regular use of Flonase (Fluticasone-propionate-nasal).

Thyroid function: People with an underactive thyroid gland (Hypothyroidism), you may experience increased effects of this medication. If you are hypothyroid or are being monitored for thyroid function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Flonase (Fluticasone-propionate-nasal), and whether any special monitoring is needed.

Vision problems: Corticosteroids such as fluticasone propionate nasal spray may cause Glaucoma or Cataracts. Report any vision changes to your doctor immediately. If you have glaucoma or cataracts, discuss with your doctor how Flonase (Fluticasone-propionate-nasal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Flonase (Fluticasone-propionate-nasal), and whether any special monitoring is needed.

Wound healing: Corticosteroids such as fluticasone propionate nasal spray can impair the ability of wounds to heal. Flonase (Fluticasone-propionate-nasal) should be avoided if you have recently had nasal surgery or nasal trauma until wounds have completely healed.

Pregnancy: The safety of fluticasone propionate nasal spray during pregnancy has not been established. Flonase (Fluticasone-propionate-nasal) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Flonase (Fluticasone-propionate-nasal), contact your doctor immediately.

Breast-feeding: It is not known if fluticasone propionate passes into breast milk. If you are a breast-feeding mother and are using Flonase (Fluticasone-propionate-nasal), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Flonase (Fluticasone-propionate-nasal) have not been established for children less than 4 years of age and should not be used by children under 4 years old. Long-term use of fluticasone propionate nasal spray is not recommended for children under 12 years old. Consult a doctor before using Flonase (Fluticasone-propionate-nasal) for children and adolescents less than 18 years of age.