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Voriconazole belongs to the family of medications called antifungals. It is used to treat certain types of invasive (inside the body) fungal infections, specifically Aspergillus or Candida infections.
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Voriconazole belongs to the family of medications called antifungals. It is used to treat certain types of invasive (inside the body) fungal infections, specifically Aspergillus or Candida infections. It works by preventing the fungus from growing.
Voriconazole may be available under multiple brand names and/or in several different forms. Any specific brand name of Voriconazole may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Voriconazole may not be used for all of the conditions discussed here.
Your doctor may have suggested Voriconazole for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Voriconazole, speak to your doctor. Do not stop taking Voriconazole without consulting your doctor.
Do not give Voriconazole to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Voriconazole if their doctor has not prescribed it.
The recommended adult starting dose of voriconazole is either 200 mg or 400 mg, taken 12 hours apart for the first 24 hours. After the first 24 hours, the recommended dose is 100 mg or 200 mg, taken twice daily. For both the starting dose and the maintenance dose, the dose used depends on your body weight and the type of infection. Your dose may be adjusted by your doctor depending on how you respond to voriconazole and the side effects you experience.
Voriconazole tablets should be taken 1 hour before or 2 hours after a meal.
Voriconazole oral suspension must be taken 1 hour before or after a meal.
If you are using the oral suspension, shake the closed bottle for approximately 10 seconds before each use. The suspension should only be administered using the oral dispenser supplied with each pack.
Voriconazole oral suspension should not be mixed with any other medication or flavouring agent and it should not be further diluted with water or any other drinks.
Injection: The dose for voriconazole intravenous (into the vein) injection depends on body weight and the type of infection. Your doctor will determine the right dose for you. The typical recommended starting dose of voriconazole injection during the first 24 hours is 2 doses of 6 mg for each kilogram of body weight, given 12 hours apart. After the first 24 hours, the recommended dose is 3 mg or 4 mg for each kilogram of body weight twice daily. Intravenous treatment with voriconazole should not exceed 6 months. The dose is usually injected slowly into a vein over 1 to 2 hours in a clinic setting (e.g., hospital). Your dose may be adjusted by your doctor depending on how you respond to voriconazole and the side effects you experience.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Your dose may be adjusted by your doctor depending on how you respond to voriconazole and the side effects you experience.
It is important to use Voriconazole exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule.
Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Voriconazole tablets and oral suspension, as well as the injectable forms of Voriconazole, should be stored at room temperature. Keep it out of reach of children. Safely discard any suspension that is left over after 14 days.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Voriconazole. If you are concerned about side effects, discuss the risks and benefits of Voriconazole with your doctor.
The following side effects have been reported by at least 1% of people taking Voriconazole. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Voriconazole.
Each single-use vial of white, sterile, lyophilized powder contains voriconazole 200 mg and sulphobutylether-ß-cyclodextrin sodium (SBECD) 3,200 mg. Preservative-free. Vials containing 200 mg lyophilized voriconazole are intended for reconstitution with water for injection to produce a solution containing 10 mg/mL voriconazole and 160 mg/mL of (SBECD) as a molecular inclusion complex.
Do not take voriconazole if you:
There may be an interaction between voriconazole and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Voriconazole. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Voriconazole.
Abnormal heart rhythms: This medication can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, droperidol, pimozide, gatifloxacin, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Dolasetron mesylate, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with voriconazole. You are more at risk for this type of abnormal heart rhythm and its complications if you:
If you have heart disease and abnormal heart rhythms, or are taking certain medications, discuss with your doctor how Voriconazole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Voriconazole, and whether any special monitoring is needed.
Allergy: It is not clear whether people who have previously had an allergic reaction to another "azole" antifungal will have an allergic reaction to voriconazole. Make certain all medical professionals involved in your care know if you have had an allergic reaction to a different antifungal medication in this class, before taking voriconazole.
Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing, or swelling of the face and throat.
Infusion related problems: Reactions may occur during the infusion of the intravenous formulation of voriconazole. These include flushing, fever, sweating, rapid heart rate, chest tightness, difficulty breathing, feeling faint, nausea, itching, and rash. Report these to your doctor if they occur, as the infusion may have to be stopped.
Kidney problems: Rarely, voriconazole has been linked to developing kidney problems. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Voriconazole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Voriconazole, and whether any special monitoring is needed.
Signs of decreasing kidney function include the production of very small amounts of urine, swelling in your legs and feet, loss of appetite, nausea, vomiting, confusion and anxiousness, or excessive sleepiness. If you notice any of these, contact your doctor as soon as possible.
Lactose: Voriconazole tablets contain lactose. If you have or suspect you have galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption, voriconazole tablets may worsen your condition.
Liver function: Liver disease or reduced liver function may cause Voriconazole to build up in the body, causing side effects. As well, voriconazole may reduce liver function and can cause liver failure. Your doctor will monitor the function of your liver while you are taking Voriconazole. If you have liver problems, discuss with your doctor how Voriconazole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Voriconazole, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Voriconazole.
Although serious liver reactions have been rare, contact your doctor if you notice signs of liver problems such as unusual fatigue, loss of appetite, nausea or vomiting, yellowing of the skin or eyes, dark urine, or pale stools. If you have severe liver cirrhosis, voriconazole should only be used if the benefits outweigh the risks, and you should be closely monitored by your doctor while you are taking the medication.
Pancreatitis (inflammation of the pancreas): Voriconazole may cause or worsen pancreatitis. If you have a history of or are at risk for developing pancreatitis (i.e., have had chemotherapy or a stem cell transplant), you should be closely monitored by your doctor while taking Voriconazole. If you develop signs of pancreatitis (e.g., upper left abdominal pain, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen), contact your doctor.
Skin reactions: In rare cases, people have had skin reactions when they have taken Voriconazole. If you get a skin rash that worsens, or if you experience exfoliating skin conditions such as peeling, shedding, or scaling of the skin, or any other unusual reaction of the skin, contact your doctor immediately. Your skin may also become sensitive to sunlight. Try to avoid strong sunlight while taking Voriconazole.
Vision changes: Voriconazole may cause blurry vision, reduced vision, colour vision change, and increased sensitivity of the eyes to sunlight. Most visual symptoms should clear up within 60 minutes. Avoid driving or operating machinery if you experience any changes in vision. Do not drive at night while taking voriconazole.
Pregnancy: Voriconazole can cause harm to the fetus when the medication is taken during pregnancy. Voriconazole should not be used during pregnancy. Women who may become pregnant should always use an effective form of birth control during treatment with voriconazole. If you become pregnant while taking Voriconazole, contact your doctor immediately.
Breast-feeding: It is not known if voriconazole passes into breast milk. If you are a breast-feeding mother and are taking Voriconazole, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Voriconazole have not been established for children less than 12 years of age.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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