Repatha

The recommended dose of Repatha (Evolocumab) for prevention of cardiovascular events and to treat primary hyperlipidemia is 140 mg injected subcutaneously (under the skin) every 2 weeks or 420 mg injected subcutaneously once a month.

To treat homozygous familial hyperlipidemia, the starting dose is 420 mg injected once monthly. After 3 months, your doctor may increase your dose to 420 mg every 2 weeks, depending on your response to Repatha (Evolocumab).

If your dose is 420 mg, you will use 1 prefilled cartridge of 420 mg or 3 prefilled autoinjectors injected one after the other, within 30 minutes. Before injecting the medication, allow it to sit at room temperature for 45 minutes if using the 420 mg cartridge or 30 minutes if using the 120 mg autoinjector. Do not warm it in any other way. Subcutaneous injections are administered in the abdomen, upper arm, or thigh area. Do not use the injection if it is discolored, cloudy, or if you can see particles in the solution.

If you are injecting Repatha (Evolocumab) yourself, your doctor will show you how to use Repatha (Evolocumab) properly. If you are not sure how to use it or have questions about how to use it, contact your doctor. Before using Repatha (Evolocumab), thoroughly read the patient information provided and, if you have any questions, ask your doctor. If a family member or caregiver will be giving you the injections, your doctor should instruct them on how to give the injection.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Repatha (Evolocumab) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible, as long as there are more than 7 days until your next scheduled dose. If there are 7 days or less until your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Repatha (Evolocumab) in the refrigerator, protect it from light and moisture, and keep it out of the reach of children. Do not freeze or shake Repatha (Evolocumab). Once it is removed from the refrigerator, it may be stored at room temperature for 30 days.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.