Uptravi (Selexipag) belongs to the class of medications called prostacyclin receptor agonists. It is used alone and in combination with other medications for long-term treatment of pulmonary arterial hypertension (PAH).
Available form
Tablet
Dosage
Manufacturer
Janssen
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The recommended starting dose of Uptravi (Selexipag) is 200 μg taken by mouth, 2 times a day. The doses should be spaced approximately 12 hours apart. Gradually, your doctor will increase your dose until you reach a dose that is effective without too many side effects. The maximum dose of Uptravi (Selexipag) is 1,600 μg taken 2 times daily.
Uptravi (Selexipag) may be taken with or without food. Taking the medication with food may reduce the severity of side effects. Swallow the tablets whole, with water. Do not split, crush, or chew the tablets.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Uptravi (Selexipag) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 6 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
If you miss taking your medication for 3 days or more, contact your doctor for directions on how to restart the medication. You may need to restart your treatment at a lower dose.
Store Uptravi (Selexipag) in its original package at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Uptravi (Selexipag). If you are concerned about side effects, discuss the risks and benefits of Uptravi (Selexipag) with your doctor.
The following side effects have been reported by at least 1% of people taking Uptravi (Selexipag). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Uptravi (Selexipag).
200 μg
Each round, light yellow, film-coated tablet with "2" debossed on one side contains 200 μg of Uptravi (Selexipag). Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide yellow (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
400 μg
Each round, red, film-coated tablet with "4" debossed on one side contains 400 μg of Uptravi (Selexipag). Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide red (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
600 μg
Each round, light violet, film-coated tablet with "6" debossed on one side contains 600 μg of Uptravi (Selexipag). Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide black (E172), iron oxide red (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
800 μg
Each round, green, film-coated tablet with "8" debossed on one side contains 800 μg of Uptravi (Selexipag). Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide black (E172), iron oxide yellow (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
1000 μg
Each round, orange, film-coated tablet with "10" debossed on one side contains 1,000 μg of Uptravi (Selexipag). Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide red (E172), iron oxide yellow (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
1200 μg
Each round, dark violet, film-coated tablet with "12" debossed on one side contains 1,200 μg of Uptravi (Selexipag). Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide black (E172), iron oxide red (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
1400 μg
Each round, dark yellow, film-coated tablet with "14" debossed on one side contains 1,400 μg of Uptravi (Selexipag). Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide yellow (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
1600 μg
Each round, brown, film-coated tablet, with "16" debossed on one side contains Uptravi (Selexipag) 1,600 μg. Nonmedicinal ingredients: carnauba wax, corn starch, D-mannitol, hydroxypropyl cellulose, hypromellose, iron oxide black (E172), iron oxide red (E172), iron oxide yellow (E172), low substituted hydroxypropyl cellulose, magnesium stearate, propylene glycol, and titanium dioxide (E171).
Do not take Uptravi (Selexipag) if you:
There may be an interaction between Uptravi (Selexipag) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Uptravi (Selexipag). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Uptravi (Selexipag).
Liver function: Liver disease or reduced liver function may cause Uptravi (Selexipag) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Uptravi (Selexipag) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Uptravi (Selexipag), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Uptravi (Selexipag). People with severely decreased liver function should not use Uptravi (Selexipag).
Low blood pressure: Uptravi (Selexipag) can cause low blood pressure to become worse. If you have any conditions that may be affected by decreased blood pressure, such as taking blood pressure medications, having low blood pressure, dehydration, or certain heart conditions, discuss with your doctor how Uptravi (Selexipag) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Uptravi (Selexipag), and whether any special monitoring is needed.
Thyroid problems: Some people taking Uptravi (Selexipag) develop changes in the function of their thyroid. Symptoms of these changes include feeling cold or hot all the time, a change in weight (gain or loss) without a change in your diet or amount of exercise you get, or feeling emotional. Contact your doctor if you experience these symptoms.
Pregnancy: Uptravi (Selexipag) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Uptravi (Selexipag), contact your doctor immediately.
Breast-feeding: It is not known if Uptravi (Selexipag) passes into breast milk. If you are a breast-feeding mother and are taking Uptravi (Selexipag), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Uptravi (Selexipag) have not been established for children.
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