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August 8, 2022

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Available Form:
Capsule
Manufacturer name:
Cheplapharm Arzneimittel Gmbh
Generic name:
orlistat
Strength:
120mg
Xenical (Orlistat) belongs to a class of medications known as anti-obesity agents, specifically gastrointestinal lipase inhibitors. When combined with a mildly reduced-calorie diet that contains no more than 30% of calories from fat, Xenical (Orlistat) is used to help obese people lose weight and maintain weight loss.
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Xenical (Orlistat) belongs to a class of medications known as anti-obesity agents, specifically gastrointestinal lipase inhibitors. When combined with a mildly reduced-calorie diet that contains no more than 30% of calories from fat, Xenical (Orlistat) is used to help obese people lose weight and maintain weight loss.
Lipase is an enzyme that is needed to breakdown dietary fats into fatty acids, which is the form of fat that gets absorbed. Xenical (Orlistat) blocks the action of lipase and therefore prevents dietary fat from being absorbed. At the recommended dose, Xenical (Orlistat) inhibits dietary fat absorption by approximately 30%.
Xenical (Orlistat) should only be used by people who have a body mass index (BMI) of 30 kg/m² or higher, or by people with a BMI of 27 kg/m² or higher with other health risk factors such as high blood pressure, Type 2 Diabetes, High Cholesterol, or large waist measurement. BMI is not a direct measure of fat and these guidelines do not apply to athletes and pregnant women.
BMI is calculated by dividing your body weight in kilograms by the square of your height in metres. For example, if you weigh 150 lbs (68 kg) and are 5 ft 8 in (1.73 m) tall, divide 68 by (1.73×1.73), or 2.99. The result is a BMI of 22.7 kg/m².
Xenical (Orlistat) can also be used in combination with diabetes medications to improve blood glucose control in overweight or obese people with type 2 diabetes whose blood glucose levels are inadequately controlled with diet, exercise, and diabetes medications (e.g., Glyburide, insulin, Metformin).
Xenical (Orlistat) may be available under multiple brand names and/or in several different forms. Any specific brand name of Xenical (Orlistat) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Xenical (Orlistat) may not be used for all of the conditions discussed here.
Your doctor may have suggested Xenical (Orlistat) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Xenical (Orlistat), speak to your doctor. Do not stop taking Xenical (Orlistat) without consulting your doctor.
Do not give Xenical (Orlistat) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Xenical (Orlistat) if their doctor has not prescribed it.
The recommended adult dose is 120 mg three times daily with each main meal (breakfast, lunch, and dinner) or up to 1 hour after the meal. If you occasionally miss a meal or the meal does not contain fat, do not take the dose of Xenical (Orlistat). Swallow the capsule whole with some water.
Xenical (Orlistat) should be taken with a mildly reduced-calorie diet that contains no more than 30% of calories from fat, as recommended by your doctor, dietitian, or other health care professional.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Xenical (Orlistat) exactly as prescribed by your doctor. If you miss a dose, it can be taken up to 1 hour after a meal and still be effective. However, if it is greater than an hour when you remember, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Xenical (Orlistat) at room temperature in the original package, protect it from moisture, and keep it away from heat and out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Xenical (Orlistat). If you are concerned about side effects, discuss the risks and benefits of Xenical (Orlistat) with your doctor.
The following side effects have been reported by at least 1% of people taking Xenical (Orlistat). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Xenical (Orlistat).
Each turquoise capsule, with "Roche Xenical 120" printed in black ink, contains 120 mg of Xenical (Orlistat). Nonmedicinal ingredients: gelatin, indigo carmine, microcrystalline cellulose, povidone K30, sodium lauryl sulfate, sodium starch glycolate, talc, and titanium dioxide.
Do not take Xenical (Orlistat) if you:
There may be an interaction between Xenical (Orlistat) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Xenical (Orlistat). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription) and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Xenical (Orlistat).
Diabetes: If you have type 2 diabetes and are taking Xenical (Orlistat) in combination with other diabetes medications, you may be more at risk of experiencing Hypoglycemia (low blood sugar). If you experience hypoglycemia symptoms such as sweating, dizziness, shakiness, hunger, or confusion, contact your doctor. Your doctor may need to adjust the dose of your medication(s). You should continue to monitor your blood sugar levels regularly.
Fat intake: It is very important to follow recommended dietary guidelines while taking Xenical (Orlistat). The risk of side effects associated with the stomach (such as gas with discharge or oily spotting of underclothes) increases when Xenical (Orlistat) is taken with a high-fat diet. Your daily intake of fat should be distributed over three main meals and should not be more than 30% of the total calories. Discuss with your doctor or dietitian if you have any concerns or questions regarding how to manage your diet.
Gastrointestinal problems: If you have bowel or rectal problems, discuss with your doctor how Xenical (Orlistat) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xenical (Orlistat), and whether any special monitoring is needed. Bleeding from the rectum has been reported with the use of Xenical (Orlistat). If this occurs, contact your doctor as soon as possible.
Kidney stones: If you have a history of kidney stones, discuss with your doctor how Xenical (Orlistat) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xenical (Orlistat), and whether any special monitoring is needed.
Liver: There have been rare reports of severe liver injury in people taking Xenical (Orlistat). If you experience any symptoms such as loss of appetite, yellow skin or eyes, abdominal pain, dark urine, light-coloured stools, or pain in the upper right part of the abdomen, contact your doctor immediately.
Seizures: Xenical (Orlistat) may interact with seizure medications by decreasing the amount of seizure medication that your body absorbs. This can result in increased seizures. If you have a history of seizures, discuss with your doctor how Xenical (Orlistat) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xenical (Orlistat), and whether any special monitoring is needed.
Thyroid: Xenical (Orlistat) may affect how well your thyroid gland works, possibly by reducing the amount of iodine available from your diet for your body to produce thyroid hormone. If you have Hypothyroidism (low thyroid hormone levels), your doctor should closely monitor your condition while you are taking Xenical (Orlistat), as it may affect thyroid levels.
Vitamins: Xenical (Orlistat) may reduce the absorption of beta-carotene and fat-soluble vitamins such as vitamin A, vitamin D, vitamin E, and vitamin K. Talk to your doctor or pharmacist about taking a multivitamin supplement. If you are already on a multivitamin, take it at least 2 hours before or after taking Xenical (Orlistat), or take it at bedtime.
Pregnancy: Xenical (Orlistat) has not been adequately studied in pregnant women. Xenical (Orlistat) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Xenical (Orlistat), contact your doctor immediately.
Breast-feeding: It is not known if Xenical (Orlistat) passes into breast milk. If you are a breast-feeding mother and taking Xenical (Orlistat), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of Xenical (Orlistat) have not been established for use in children less than 12 years of age.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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