Banzel (Rufinamide) belongs to the class of medications called antiepileptics (anti-seizure medications). It is used along with other seizure medications to help control the seizures associated with Lennox-Gastaut syndrome in adults and children 4 years of age and older. Lennox-Gastaut syndrome is a seizure disorder where the person experiences frequent seizures and different types of seizures. Banzel (Rufinamide) is not used to treat other seizure disorders.

Your doctor may have suggested Banzel (Rufinamide) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Banzel (Rufinamide), speak to your doctor. Do not stop taking Banzel (Rufinamide) without consulting your doctor.

Do not give Banzel (Rufinamide) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Banzel (Rufinamide) if their doctor has not prescribed it.

The recommended starting dose for people who weigh less than 30 kg is 100 mg taken twice a day. The recommended starting dose for people who weigh more than 30 kg is 200 mg taken twice a day.

Depending on your body's response to the medication and side effects, your doctor will gradually increase your daily dose until your seizures are controlled. The maximum daily dose is based on your body weight.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

In order to get the most benefit from each dose, take Banzel (Rufinamide) with food.

It is important to take Banzel (Rufinamide) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Banzel (Rufinamide) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Banzel (Rufinamide). If you are concerned about side effects, discuss the risks and benefits of Banzel (Rufinamide) with your doctor.

The following side effects have been reported by at least 1% of people taking Banzel (Rufinamide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• decreased appetite
• dizziness
• headache
• nausea
• sleepiness
• tiredness
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• balance problems
• difficulty walking
• signs of Depression (e.g., poor concentration, changes in weight, changes in
• signs of liver problems (e.g., nausea, vomiting, Diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• vision changes (e.g., double vision, blurred vision)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• thoughts of suicide or harming yourself
• signs of allergic reaction (e.g., rash, facial swelling, Fever, swollen lymph nodes)
• signs of an irregular heartbeat (e.g., dizziness, palpitations [pounding or racing heartbeat], fainting or loss of consciousness)
• severe skin rash (e.g., blistering, peeling, or loosening of the skin and mucous membranes)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Banzel (Rufinamide).

100 mg
Each pink, oval-shaped, slightly convex, film-coated tablet, with a score on both sides and marked with "€261" on one side, contains 100 mg of Banzel (Rufinamide). Nonmedicinal ingredients: colloidal silicon dioxide, corn starch, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulphate; film coating: hypromellose, iron oxide red, polyethylene glycol, talc, and titanium dioxide.

200 mg
Each pink, oval-shaped, slightly convex, film-coated tablet, with a score on both sides and marked with "€262" on one side, contains 200 mg of Banzel (Rufinamide). Nonmedicinal ingredients: colloidal silicon dioxide, corn starch, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulphate; film coating: hypromellose, iron oxide red, polyethylene glycol, talc, and titanium dioxide.

400 mg
Each pink, oval-shaped, slightly convex, film-coated tablet, with a score on both sides and marked with "€263" on one side, contains 400 mg of Banzel (Rufinamide). Nonmedicinal ingredients: colloidal silicon dioxide, corn starch, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulphate; film coating: hypromellose, iron oxide red, polyethylene glycol, talc, and titanium dioxide.

Do not take Banzel (Rufinamide) if you:

• are allergic to Banzel (Rufinamide) or any ingredients of Banzel (Rufinamide)
• are allergic to any of the "azole" antifungal drugs (e.g., fluconazole, ketoconazole)
• have a heart arrhythmia called familial short QT syndrome or have a family history or history of short QT syndrome

Do not give Banzel (Rufinamide) to children under 4 years of age.

There may be an interaction between Banzel (Rufinamide) and any of the following:

• alcohol
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• anti-psychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• barbiturates (e.g., butalbital, Phenobarbital)
• benzodiazepines (e.g., Clonazepam, Diazepam, Lorazepam)
• birth control pills
• Buspirone
• chloral hydrate
• Entacapone
• Methadone
• Mirtazapine
• muscle relaxants (e.g., Baclofen, Cyclobenzaprine, methocarbamol, orphenadrine)
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• Olopatadine
• scopolamine
• other seizure medications (e.g.,  Carbamazepine, Clobazam, Levetiracetam, phenobarbital, phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
• Tapentadol
• tolcapone
• Tramadol
• tricyclic antidepressants (e.g., Amitriptyline, Desipramine, Nortriptyline)
• Zopiclone
• Zolpidem

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Banzel (Rufinamide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.