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Chlorthalidone belongs to the group of medications called diuretics. It is also an antihypertensive.
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Chlorthalidone belongs to the group of medications called diuretics. It is also an antihypertensive. Chlorthalidone is used to treat fluid retention (edema) occurring with Congestive Heart Failure and disorders of the liver and kidney. It is also used alone or in combination with other medications to treat high blood pressure. Chlorthalidone works by making the body lose excess water and salt.
Chlorthalidone may be available under multiple brand names and/or in several different forms. Any specific brand name of Chlorthalidone may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Chlorthalidone may not be used for all of the conditions discussed here.
Your doctor may have suggested Chlorthalidone for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Chlorthalidone, speak to your doctor. Do not stop taking Chlorthalidone without consulting your doctor.
Do not give Chlorthalidone to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Chlorthalidone if their doctor has not prescribed it.
The usual recommended dose of chlorthalidone is 25 mg to 100 mg once daily or in divided doses.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Chlorthalidone exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Chlorthalidone at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Chlorthalidone. If you are concerned about side effects, discuss the risks and benefits of Chlorthalidone with your doctor.
The following side effects have been reported by at least 1% of people taking Chlorthalidone. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Signs and symptoms of too much potassium loss:
Signs and symptoms of too much sodium loss:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Chlorthalidone.
Chlorthalidone is available as a 50 mg tablet.
Do not take chlorthalidone if you:
If the passage of urine continues to increase over time during treatment of severe progressive Kidney Disease, chlorthalidone should be stopped.
There may be an interaction between chlorthalidone and any of the following:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Chlorthalidone. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Chlorthalidone.
Cholesterol: Increases in cholesterol and triglyceride levels may occur when you are taking chlorthalidone. Your doctor will monitor your cholesterol and triglyceride levels with blood tests while you are taking Chlorthalidone.
Diabetes: Chlorthalidone may make it more difficult for people with diabetes to control their blood sugar. If you have diabetes, discuss with your doctor how Chlorthalidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Chlorthalidone, and whether any special monitoring is needed.
Dizziness/slower reaction: Because dizziness and a slower reaction time are possible side effects of taking chlorthalidone, especially at the start of therapy, you should see how the medication affects you before operating machines or driving motor vehicles.
Fluid and electrolyte balance: The levels of electrolytes in your body such as potassium, sodium, magnesium, and chloride can be reduced by the use of chlorthalidone. Your doctor will periodically check to see whether these are in balance, and a potassium supplement may be necessary. Warning signs or symptoms of fluid and electrolyte imbalance include:
If you experience any of these symptoms, contact your doctor. To prevent low potassium levels, eat foods that are high in potassium (e.g., bananas, dried figs, dates, prunes, nuts). If your potassium level is low, your doctor may suggest a potassium supplement.
Gout: Chlorthalidone may aggravate or cause gout. People with high levels of uric acid in the blood or a history of gout should discuss with their doctor how Chlorthalidone may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Chlorthalidone, and whether any special monitoring is needed.Kidney disease: If you have reduced kidney function, discuss with your doctor how Chlorthalidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Chlorthalidone, and whether any special monitoring is needed.
Liver disease: If you have reduced liver function or progressive liver disease, discuss with your doctor how Chlorthalidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Chlorthalidone, and whether any special monitoring is needed.
Lupus: Chlorthalidone may worsen or activate the symptoms of lupus. If you experience swollen and painful joints, fever, fatigue, or rash on the nose and cheeks while taking Chlorthalidone, contact your doctor.
Pregnancy: Chlorthalidone should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Chlorthalidone, contact your doctor immediately.
Breast-feeding: Chlorthalidone passes into breast milk. If you are a breast-feeding mother and are taking chlorthalidone, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Chlorthalidone have not been established for children.
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