Rituxan (Rituximab) belongs to the group of cancer-fighting medications known as antineoplastics. It is used to treat:

• certain forms of Non-Hodgkin's Lymphoma
• Chronic Lymphocytic Leukemia (CLL)
• moderate-to-severe Rheumatoid Arthritis (in combination with Methotrexate) in adults who have not responded to treatment with a group of medications called biologics or tumour necrosis factor (TNF) blockers
• granulomatosis with polyangiitis (Wegener's granulomatosis) and microscopic polyangiitis

Rituxan (Rituximab) SC is only used to treat non-Hodgkin's lymphoma and CLL.

Rituxan (Rituximab) treats cancer and rheumatoid arthritis by attacking and killing the cells that are causing the condition.

Your doctor may have suggested Rituxan (Rituximab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Rituxan (Rituximab), speak to your doctor. Do not stop taking Rituxan (Rituximab) without consulting your doctor.

Do not give Rituxan (Rituximab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Rituxan (Rituximab) if their doctor has not prescribed it.

Rituxan (Rituximab) IV:

Rituxan (Rituximab) should only be given by health care professionals that are experienced treating the conditions that Rituxan (Rituximab) is used for.

For non-Hodgkin's lymphoma and chronic lymphocytic leukemia, the recommended dose and dosing schedule of Rituxan (Rituximab) varies according to body size, the condition being treated, and other medications that are being used.

It is injected intravenously (into a vein) by a health care professional, usually in a clinical setting such as a hospital clinic, over a period of time. This process is called an intravenous infusion.

For rheumatoid arthritis, the recommended dose is 1,000 mg for the first dose, followed 2 weeks later by a second dose of 1,000 mg. The medication is injected into a vein (IV) over a period of time in by a health care professional, usually in a clinic setting.

For Wegener's granulomatosis, the recommended dose is 375 mg/m² of body surface area, given once weekly for 4 weeks.

Very careful handling of Rituxan (Rituximab) is required. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

It is important to receive Rituxan (Rituximab) exactly as recommended by your doctor. If you miss an appointment to receive Rituxan (Rituximab), contact your doctor as soon as possible to reschedule your appointment.

Many things can affect the dose and schedule of medication that a person needs, such as body size, other medical conditions, and other medications. Your doctor may choose a schedule different from the one above.

Rituxan (Rituximab) is stored in the refrigerator at 2°C to 8°C and protected from light.

Rituxan (Rituximab) SC:

Rituxan (Rituximab) SC is used only after the first dose of Rituxan (Rituximab) has been given by intravenous infusion and is tolerated. The recommended adult dose of Rituxan (Rituximab) SC is 1400 mg injected subcutaneously (under the skin) of the stomach on day 1 of each cycle of chemotherapy after the first cycle has been completed.

Very careful handling of Rituxan (Rituximab) is required. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

It is important to receive Rituxan (Rituximab) exactly as recommended by your doctor. If you miss an appointment to receive Rituxan (Rituximab), contact your doctor as soon as possible to reschedule your appointment.

Many things can affect the dose and schedule of medication that a person needs, such as body size, other medical conditions, and other medications. Your doctor may choose a schedule different from the one above.

Rituxan (Rituximab) should be stored in the refrigerator at 2°C to 8°C and protected from light.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who receives Rituxan (Rituximab). If you are concerned about side effects, discuss the risks and benefits of Rituxan (Rituximab) with your doctor.

The following side effects have been reported by at least 1% of people receiving Rituxan (Rituximab). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• dizziness
• fatigue
• flushing
• general feeling of discomfort or illness
• headache
• heartburn
• itching
• nausea
• redness, irritation, or pain at the injection site (Rituxan (Rituximab) SC only)
• vomiting
• weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blood pressure changes
• chest tightness
• dizziness or lightheadedness when rising from a lying or sitting position
• feeling of swelling of tongue and throat
• Fever and chills
• heart rate changes
• mood changes
• muscle or joint pain
• numbness or weakness on one side of your body
• redness of blistering of the skin or inside the mouth
• runny nose
• shortness of breath or difficulty breathing
• signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
• signs and symptoms of kidney problems such as lower back or side pain, swelling of the feet or lower legs, or numbness or tingling in the feet or hands
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood,  bleeding gums, cuts that don't stop bleeding)
• signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling)
• signs of liver problems (including hepatitis B) such as abdominal pain, feeling of sickness, joint pain, loss of appetite, tiredness, yellowing of the skin and eyes (jaundice)
• skin rash or itchy skin
• swelling of hands and feet
• symptoms of an infection such as fever, chills, pain, sore throat, redness or swelling, difficult or painful urination, cough
• symptoms of Shingles such as itching, tingling or severe burning pain with red patches that turn into blisters
• tingling sensations
• trouble thinking or memory problems
• unusual tiredness
• vision changes
• wheezing
• weight loss

Seek immediate medical attention if any of the following occur:

• chest pain or pressure
• difficulty breathing
• seizures
• signs of a severe skin rash (e.g., peeling or blistering skin, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)
• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
• signs and symptoms of bowel blockage such as nausea, vomiting, abdominal swelling or pain, Constipation, or Diarrhea
• signs and symptoms of bowel perforation such as sudden abdominal pain (worse with movement), abdominal tenderness, high fever, chills, nausea, and vomiting
• signs of progressive multifocal leukoencephalopathy (PML) (e.g., memory loss, vision loss, difficulty thinking or walking)
• signs of Stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
• symptoms of an allergic reaction such as difficulty breathing, Hives, and swelling of the face or throat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Rituxan (Rituximab).

10 mg/mL solution for intravenous infusion

Each mL of sterile, clear, colourless liquid concentrate for IV (intravenous) administration contains 10 mg of Rituxan (Rituximab). Nonmedicinal ingredients: hydrochloric acid, polysorbate 80, sodium chloride, sodium citrate, sodium hydroxide, and sterile water for injection. Rituxan (Rituximab) does not contain preservatives.

120 mg/mL solution for subcutaneous injection

Each 1 mL of colorless-to-yellowish, clear-to-opalescent solution supplied in sterile, preservative-free, non-pyrogenic single-dose vial, contains 120 mg of Rituxan (Rituximab). Nonmedicinal ingredients: recombinant human hyaluronidase (rHuPH20), L-histidine, L-histidine hydrochloride monohydrate, α,α-trehalose dehydrate, L-methionine, polysorbate 80, water for injection.

Do not receive Rituxan (Rituximab) if you:

• are allergic to Rituxan (Rituximab) or any ingredients of Rituxan (Rituximab)
• are allergic to proteins of similar origin
• have a severe infection
• have or have had progressive multifocal leukoencephalopathy (PML), a rare disorder associated with nerve damage in the brain

There may be an interaction between Rituxan (Rituximab) and any of the following:

• Abatacept
• alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• alpha agonists (e.g., Clonidine, methyldopa)
• angiotensin converting enzyme inhibitors (ACEIs; Captopril, Ramipril)
• angiotensin receptor blockers (ARBs; e.g., candasartan, Irbesartan, Losartan)
• bacillus Calmette-Guérin (BCG) (intravesical)
• Belimumab
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Certolizumab Pegol
• Clozapine
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• echinacea
• Fingolimod
• Leflunomide
• Natalizumab
• Nivolumab
• Pimecrolimus
• Roflumilast
• Tacrolimus
• tofacititinb
• Trastuzumab
• vaccines

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Rituxan (Rituximab). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.