Follitropin alpha belongs to the class of medications called gonadotropins. It is a synthetic version of the naturally-occurring follicle stimulating hormone (FSH), a hormone produced by the pituitary gland that helps egg development in the ovaries.
Available form
Injectable
Dosage
Manufacturer
Emd Canada
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The recommended dose of follitropin alpha varies according to individual circumstances. The goal is to use the lowest dose that is expected to achieve good results. Doses usually range from 75 IU to 450 IU (5.5 µg to 33 µg) per day.
To induce ovulation, treatment is usually started at a dose of 75 IU once daily. The dose can be increased by up to 37.5 IU by the doctor after 14 days, and then every 7 days after that. One course of treatment should not exceed 35 days under normal circumstances. Intercourse should be attempted at a consistent frequency of at least 3 times per week from the day prior to administration of hCG until ovulation becomes apparent. If there is evidence of ovulation but pregnancy does not occur, the regimen is repeated for at least 2 more courses before the dose is increased to 150 IU per day for 7 to 12 days.
For ART procedures, treatment is usually started at a dose of 150 IU or 225 IU (depending on your circumstances) once a day. After the first 5 days, your doctor may consider increasing the dose by 37.5 IU to 150 IU. Additional dose increases can be made every 3 to 5 days.
After preparation, follitropin alpha is injected either under the skin (subcutaneous) or into a muscle (intramuscular) as directed, usually into the thigh or abdomen.
If you are giving the injection to yourself, be sure you completely understand the proper method of safely preparing and injecting your medication.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is very important to use Gonal F Pen (Follitropin-alpha) on a regular schedule and exactly as prescribed by your doctor. If you miss a dose of Gonal F Pen (Follitropin-alpha), discuss with your doctor when you should receive your next dose. Do not administer a double dose to make up for a missed one.
Vials with powder should be stored at or below room temperature, protected from light, not allowed to freeze, and kept out of the reach of children. The medication should be used immediately after mixing and any unused medication should be discarded.
The pen may be stored in the refrigerator. It may also be stored at room temperature for a single period of not more than 3 months. After first use, the pen can be kept at room temperature for up to 28 days. Do not freeze the pen. Protect it from light, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Gonal F Pen (Follitropin-alpha). If you are concerned about side effects, discuss the risks and benefits of Gonal F Pen (Follitropin-alpha) with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Gonal F Pen (Follitropin-alpha).
300 IU/0.5 mL (22 µg/0.5 mL)
1 prefilled pen and 5 needles to be used with the pen for subcutaneous administration. Nonmedicinal ingredients: disodium phosphate dihydrate, L-methionine, m-cresol, phosphoric acid, poloxamer 188, sodium dihydrogen phosphate monohydrate, sodium hydroxide, sucrose, and water for injection.
450 IU/0.75 mL (33 µg/0.75 mL)
1 prefilled pen and 7 needles to be used with the pen for subcutaneous administration. Nonmedicinal ingredients: disodium phosphate dihydrate, L-methionine, m-cresol, phosphoric acid, poloxamer 188, sodium dihydrogen phosphate monohydrate, sodium hydroxide, sucrose, and water for injection.
900 IU/1.5 mL (66 µg/1.5 mL)
1 prefilled pen and 14 needles to be used with the pen for subcutaneous administration. Nonmedicinal ingredients: disodium phosphate dihydrate, L-methionine, m-cresol, phosphoric acid, poloxamer 188, sodium dihydrogen phosphate monohydrate, sodium hydroxide, sucrose, and water for injection.
There is no latex in the components of the prefilled pen.
Do not use Gonal F Pen (Follitropin-alpha) if you:
There may be an interaction between follitropin alpha and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood Clots: Gonal F Pen (Follitropin-alpha) may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities. Talk to your doctor about the risks and benefits of using Gonal F Pen (Follitropin-alpha).
Ectopic pregnancies: Gonal F Pen (Follitropin-alpha) may increase the risk of having an Ectopic Pregnancy (i.e., the baby develops in one of the fallopian tubes instead of in the uterus). It is important to have an early ultrasound to ensure that the baby is developing inside the uterus.
Instructions: It is extremely important to understand your treatment and to follow instructions closely. Be sure to ask your doctor any questions you might have.
Lung problems: Rarely, Gonal F Pen (Follitropin-alpha) can cause problems with the lungs. Get immediate medical attention if you experience wheezing or difficulty breathing.
Multiple births: Gonal F Pen (Follitropin-alpha) may increase the risk of multiple births (e.g., twins). Talk to your doctor about the risks of multiple births before beginning treatment.
Ovarian enlargement: Some women using Gonal F Pen (Follitropin-alpha) may experience ovarian enlargement associated with abdominal bloating or pain. In most cases, the bloating and pain stop without treatment within 2 or 3 weeks. If you experience these symptoms contact your doctor.
Ovarian hyperstimulation syndrome (OHSS): Treatment with Gonal F Pen (Follitropin-alpha) can cause a condition called ovarian hyperstimulation syndrome (OHSS). With OHSS, too many follicles grow and cause abdominal or pelvic discomfort or pain, nausea, vomiting, and weight gain. Some women may experience difficulty breathing, diarrhea, and decreased urination. OHSS can progress rapidly and may become serious. If you experience any of these symptoms while using this medication, contact your doctor immediately.
Pregnancy: Gonal F Pen (Follitropin-alpha) should not be used during pregnancy.
Breast-feeding: It is not known if Gonal F Pen (Follitropin-alpha) passes into breast milk. If you are a breast-feeding mother and are taking Gonal F Pen (Follitropin-alpha), it may affect your baby. Gonal F Pen (Follitropin-alpha) should not be used while breast-feeding.
Children: Gonal F Pen (Follitropin-alpha) is intended for use by women of child-bearing age and therefore, the safety and effectiveness of Gonal F Pen (Follitropin-alpha) have not been established for children.
Seniors: Gonal F Pen (Follitropin-alpha) is intended for use by women of child-bearing age and therefore, the safety and effectiveness of Gonal F Pen (Follitropin-alpha) have not been established for seniors.
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