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Available Form:   Injectable Powder
Manufacturer name:   Pfizer
Generic name:   infliximab
Strength:   100mg

What is Inflectra?

Inflectra (Infliximab) belongs to the class of medications called biological response modifiers ("biologics") or TNF blockers. It is used to treat: active ankylosing spondylitis in adults who have not responded to other therapies or who have experienced unacceptable side effects with other therapies active Psoriatic Arthritis in adults moderate-to-severe chronic plaque psoriasis in adults (after phototherapy has been shown ineffective or inappropriate) moderate-to-severe Rheumatoid Arthritis in adults when used in combination with Methotrexate fistulating Crohn's Disease in adults who have not responded to other therapies moderate-to-severe active Crohn's disease in adults s who have not responded to other therapies moderate-to-severe active Ulcerative Colitis in adults who have not responded to other therapies If you have one of these conditions, your body overproduces a protein called tumour necrosis factor (TNF), which causes pain, inflammation, and damage.

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Inflectra How to Take

Inflectra (Infliximab) belongs to the class of medications called biological response modifiers ("biologics") or TNF blockers. It is used to treat:

  • active ankylosing spondylitis in adults who have not responded to other therapies or who have experienced unacceptable side effects with other therapies
  • active Psoriatic Arthritis in adults
  • moderate-to-severe chronic plaque psoriasis in adults (after phototherapy has been shown ineffective or inappropriate)
  • moderate-to-severe Rheumatoid Arthritis in adults when used in combination with Methotrexate
  • fistulating Crohn's Disease in adults who have not responded to other therapies
  • moderate-to-severe active Crohn's disease in adults s who have not responded to other therapies
  • moderate-to-severe active Ulcerative Colitis in adults who have not responded to other therapies

If you have one of these conditions, your body overproduces a protein called tumour necrosis factor (TNF), which causes pain, inflammation, and damage. Inflectra (Infliximab) blocks the production of TNF and decreases the inflammation in the joints and on the skin. You may start to notice an improvement in symptoms about 2 weeks after starting treatment.

Your doctor may have suggested Inflectra (Infliximab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Inflectra (Infliximab), speak to your doctor. Do not stop using Inflectra (Infliximab) without consulting your doctor.

Do not give Inflectra (Infliximab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Inflectra (Infliximab) if their doctor has not prescribed it.

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Inflectra Dosage

The recommended dose of Inflectra (Infliximab) depends on the condition being treated and varies according to body weight.

It is injected intravenously (into a vein) by a health care professional, usually in a clinical setting such as a hospital clinic, over several hours. This process is called an intravenous infusion. You should keep all your appointments and follow-ups as recommended by your doctor.

The appropriate dose for the following conditions is usually given 2 and 6 weeks after the first dose, then every 8 weeks thereafter:

  • Crohn's disease
  • rheumatoid arthritis
  • ulcerative colitis
  • psoriatic arthritis
  • plaque psoriasis

For ankylosing spondylitis, the appropriate dose is usually given 2 and 6 weeks after the first dose, then every 6 to 8 weeks thereafter.

It is important to receive Inflectra (Infliximab) exactly as recommended by your doctor. If you miss an appointment to receive Inflectra (Infliximab), contact your doctor as soon as possible to reschedule your appointment.

Many things can affect the dose and schedule of medication that a person needs, such as body weight, other medical conditions, and other medications. Your doctor may choose a schedule different from the one above.

Inflectra (Infliximab) must be refrigerated at 2°C to 8°C (do not freeze it) and kept out of the reach of children. Inflectra (Infliximab) does not contain preservatives and must be mixed with sterile water for injection before IV infusion. Once the powder has been mixed, it should be used within 3 hours.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Inflectra Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Inflectra (Infliximab). If you are concerned about side effects, discuss the risks and benefits of Inflectra (Infliximab) with your doctor.

The following side effects have been reported by at least 1% of people taking Inflectra (Infliximab). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • back pain
  • cough
  • Diarrhea
  • dizziness
  • fatigue
  • headache
  • itch
  • upset stomach

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • Fever or chills
  • joint pain
  • shortness of breath
  • signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
  • signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling)
  • signs of nervous system problems (e.g., vision changes, weakness in arms, legs or numbness or tingling in any part of the body)
  • skin rash
  • symptoms of an infection (e.g., fever, chills, pain, swelling, or pus)
  • symptoms of liver damage (e.g., yellow skin or eyes, dark urine, loss of appetite, abdominal pain, fever, and fatigue)
  • symptoms of Lupus (e.g., chest discomfort/pain, shortness of breath, joint pain, rash on the cheeks or arms)
  • symptoms of upper respiratory infections (e.g., sore throat, fever, cough, fatigue, chest congestion)
  • symptoms of a urinary tract infection (e.g. pain when urinating, urinating more often than usual, low back or flank pain)

Seek immediate medical attention if any of the following occur:

  • seizures
  • symptoms of an allergic reaction (such as difficulty breathing, Hives, swelling of the face or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Inflectra (Infliximab).

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Inflectra Available Form

Each vial of sterile white lyophilized powder for intravenous infusion contains 100 mg of Inflectra (Infliximab). Nonmedicinal ingredients: 500 mg of sucrose, 0.5 mg of polysorbate 80, 2.2 mg of sodium dihydrogen phosphate monohydrate, and 6.1 mg of di-sodium hydrogen phosphate dihydrate.

References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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