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What is Entyvio?

Entyvio (Vedolizumab) belongs to the class of medications called biologic response modifiers. It is used for the treatment of adults with moderately to severely active Ulcerative Colitis or Crohn's Disease when there has been a poor response to other treatments, or these treatments are no longer effective or have unacceptable side effects.

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Entyvio Indication

Entyvio (Vedolizumab) belongs to the class of medications called biologic response modifiers. It is used for the treatment of adults with moderately to severely active Ulcerative Colitis or Crohn's Disease when there has been a poor response to other treatments, or these treatments are no longer effective or have unacceptable side effects.

Ulcerative colitis is a disease in which the large bowel becomes inflamed, resulting in symptoms such as abdominal pain and cramping, Diarrhea, rectal pain, and rectal bleeding. Crohn's disease is a disease where there is chronic inflammation of the gastrointestinal tract. Entyvio (Vedolizumab) works specifically in the digestive system to reduce the activity of a protein that causes the inflammation that causes the symptoms of ulcerative colitis and Crohn's disease.

Entyvio (Vedolizumab) may be available under multiple brand names and/or in several different forms. Any specific brand name of Entyvio (Vedolizumab) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Entyvio (Vedolizumab) may not be used for all of the conditions discussed here.

Your doctor may have suggested Entyvio (Vedolizumab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Entyvio (Vedolizumab), speak to your doctor. Do not stop taking Entyvio (Vedolizumab) without consulting your doctor.

Do not give Entyvio (Vedolizumab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Entyvio (Vedolizumab) if their doctor has not prescribed it.

Entyvio Dosage

The usual adult dose of Entyvio (Vedolizumab) is 300 mg given by intravenous (into a vein) injection over 30 minutes. The first three doses are given with the first on week 0, then 2 weeks after the first dose, then 6 weeks after the first dose. After the first 3 doses, further treatments are given every 8 weeks.

All treatments are given in a hospital or similar setting with access to sterile equipment for preparation of the medication and facilities to treat medical emergencies, such as infusion reactions.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important Entyvio (Vedolizumab) be given exactly as recommended by your doctor. If you miss an appointment to receive Entyvio (Vedolizumab), contact your doctor as soon as possible to reschedule your appointment.

Entyvio (Vedolizumab) must be refrigerated at 2°C to 8°C (do not freeze), protected from light, and kept out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Entyvio Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Entyvio (Vedolizumab). If you are concerned about side effects, discuss the risks and benefits of Entyvio (Vedolizumab) with your doctor.

The following side effects have been reported by at least 1% of people taking Entyvio (Vedolizumab). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • fatigue
  • Fever
  • headache
  • joint pain
  • nausea

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • cold or flu symptoms (e.g., sore throat, cough, runny nose)
  • signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a Anaphylaxis (severe allergic reaction) (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of an infusion reaction (e.g., rash, itching, feeling hot, rapid, pounding heartbeat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Entyvio (Vedolizumab).

Entyvio Available form

Each single-use vial containing a white-to-off-white cake contains 300 mg of Entyvio (Vedolizumab). Nonmedicinal ingredients: L-histidine, L-histidine monohydrochloride, L-arginine hydrochloride, sucrose, and polysorbate 80.

Entyvio Contraindications

Do not take Entyvio (Vedolizumab) if you:

  • are allergic to Entyvio (Vedolizumab) or any ingredients of the medication
  • have severe, active infections such as blood infections
  • have active infections that develop when your immune system is weakened such as Tuberculosis or cytomegalovirus

Entyvio Precautions

There may be an interaction between Entyvio (Vedolizumab) and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Entyvio (Vedolizumab). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Entyvio Warnings

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Entyvio (Vedolizumab).

Allergic reactions: In rare cases, some people may develop a severe allergic reaction to Entyvio (Vedolizumab). These reactions may not occur with the first infusion of the medication, and may happen with future doses of Entyvio (Vedolizumab). Your health care provider will monitor you while you are receiving Entyvio (Vedolizumab) by infusion. Signs of an allergic reaction include a severe rash, Hives, swollen face or throat, difficulty breathing, lightheadedness, or dizziness. If any of these occur, contact your doctor immediately.

Infections: Entyvio (Vedolizumab) may increase the risk of developing an infection, including serious infections such as sepsis, pneumonia, and tuberculosis. Before starting Entyvio (Vedolizumab) treatment, your doctor may test to see if you have tuberculosis. If you notice signs of an infection such as fever, chills, pain, swelling, coughing, or pus, contact your doctor as soon as possible. Entyvio (Vedolizumab) should also not be started while you have an active infection.

Liver function: Entyvio (Vedolizumab) can cause decreased liver function. If you have liver problems, discuss with your doctor how Entyvio (Vedolizumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Entyvio (Vedolizumab), and whether any special monitoring is needed. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Progressive multifocal leukoencephalopathy (PML): Although there have not been reports of PML after using Entyvio (Vedolizumab), it has been reported with other medications in the same family. PML is a rare disorder that causes nerve damage in the brain. If you experience memory loss, vision loss, trouble thinking, or difficulty walking, contact your doctor immediately.

Vaccines: Live vaccines (e.g., BCG, yellow fever) are not recommended for people taking Entyvio (Vedolizumab). Talk to your doctor if you need any vaccinations while taking Entyvio (Vedolizumab).

Pregnancy: Entyvio (Vedolizumab) should not be used during pregnancy. If you are of childbearing age, effective birth control should be used while you are being treated with Entyvio (Vedolizumab) and for at least 18 weeks after your final treatment. If you become pregnant while taking Entyvio (Vedolizumab), contact your doctor immediately.

Breast-feeding: Entyvio (Vedolizumab) passes into breast milk. If you are a breast-feeding mother and are taking Entyvio (Vedolizumab), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Entyvio (Vedolizumab) have not been established for children.

Entyvio frequently asked questions

How To Buy Entyvio Online?

You can buy Entyvio online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Entyvio?

You can consult a Canadian doctor online at pocketpills.com. Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Entyvio in Canada?

Shipping cost for Entyvio to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Entyvio delivered to my home?

You could get Entyvio delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Entyvio in Canada for free?

You can get Entyvio for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Entyvio for free.

Can I consult a doctor online to get Entyvio?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Entyvio.

Can I buy Entyvio without a prescription?

You need a valid prescription to buy Entyvio from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.


All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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