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Stelara (Ustekinumab) belongs to the class of medications called selective immunomodulating agents, also known as biologics. It is used to treat chronic, moderate-to-severe plaque psoriasis for adults who are candidates for phototherapy or systemic therapy.
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Stelara (Ustekinumab) belongs to the class of medications called selective immunomodulating agents, also known as biologics. It is used to treat chronic, moderate-to-severe plaque psoriasis for adults who are candidates for phototherapy or systemic therapy. It is also used for children and adolescents 6 to 17 years old who can't tolerate other therapies, or whose symptoms aren't controlled by other therapies. Stelara (Ustekinumab) may be used alone or with Methotrexate to treat adults with active Psoriatic Arthritis.
Stelara (Ustekinumab) is also used to treat adults with moderately-to-severely active Crohn's Disease or Ulcerative Colitis who can't tolerate other medications, or whose symptoms aren't adequately controlled by other medications.
Stelara (Ustekinumab) works by blocking the action of 2 proteins in the body that are part of the immune system. This decreases the activity of parts of the immune system that are believed to be involved in psoriasis and Crohn's disease.
Your doctor may have suggested Stelara (Ustekinumab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Stelara (Ustekinumab), speak to your doctor. Do not stop using Stelara (Ustekinumab) without consulting your doctor.
Do not give Stelara (Ustekinumab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Stelara (Ustekinumab) if their doctor has not prescribed it.
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To treat adults with either plaque psoriasis or psoriatic arthritis, the usual dose is 45 mg injected under the skin. The dose is repeated in 4 weeks, and then every 12 weeks thereafter. For people who weigh more than 100 kg, a dose of 90 mg may be used. When treating plaque psoriasis, some people may need to receive Stelara (Ustekinumab) every 8 weeks. The dose may be injected on top of the thigh or around the abdomen (about 2 inches away from the belly button).
For treating children and adolescents 6 to 17 years of age with plaque psoriasis, the dose is based on body weight.
For the treatment of Crohn's disease and ulcerative colitis, the first dose is given as an intravenous (into a vein) infusion and the dose is based on body weight. The dose is repeated as an injection under the skin 8 weeks after the first dose. The usual maintenance dose is 90 mg every 8 weeks. Under certain conditions, your doctor may decrease the frequency of your injections to once every 12 weeks.
Most people using Stelara (Ustekinumab) can be trained by a health care professional to give themselves the injection. Stelara (Ustekinumab) is used with the guidance and supervision of a doctor. Your doctor or nurse will assist you in the preparation and injection of your first dose (or first few doses). Do not attempt to inject Stelara (Ustekinumab) on your own until you completely understand how to inject a dose.
Follow the instructions from your doctor or pharmacist when administering the medication. The solution should be colourless or slightly yellow and may contain a few small clear or white particles of protein. Do not use the injection if it appears cloudy or discoloured, or if you see other particles floating in it. After taking the medication out of the refrigerator, preparing the syringe, and choosing the injection site, inject the dose under the skin as instructed by your health care provider.
Use a different site for each injection to decrease the risk of skin irritation. Dispose of your used needles in an appropriate sharps container.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important that Stelara (Ustekinumab) be given exactly as recommended by your doctor. If you miss a dose, contact your doctor for advice. Do not inject a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Stelara (Ustekinumab) in the refrigerator in its original carton, protect it from light, and keep it out of the reach of children. If necessary, pre-filled syringes may be kept at room temperature for up to 30 days. Once a syringe has been stored at room temperature, it should not be returned to the refrigerator. Do not freeze or shake the medication.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who uses Stelara (Ustekinumab). If you are concerned about side effects, discuss the risks and benefits of Stelara (Ustekinumab) with your doctor.
The following side effects have been reported by at least 1% of people using Stelara (Ustekinumab). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop using the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Stelara (Ustekinumab).
Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.
Each mL of sterile solution contains 90 mg of Stelara (Ustekinumab). It is available as a pre-filled syringe containing 45 mg (0.5 mL) or 90 mg (1.0 mL) of Stelara (Ustekinumab). Nonmedicinal ingredients: L-histidine, L-histidine monohydrochloride monohydrate, polysorbate 80, sucrose, and water for injection.
Each mL of sterile solution contains 5 mg of Stelara (Ustekinumab). It is available as a solution for intravenous infusion containing 130 mg per 26 mL. Nonmedicinal ingredients: sucrose, L-histidine and L-histidine hydrochloride monohydrate, polysorbate 80, L-methionine, and EDTA disodium salt dihydrate.
Do not use Stelara (Ustekinumab) if you:
We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.
There may be an interaction between Stelara (Ustekinumab) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Stelara (Ustekinumab). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Stelara (Ustekinumab).
Allergic reaction: In rare cases, some people may develop a serious allergic reaction to Stelara (Ustekinumab). Signs of an allergic reaction include a severe rash, hives, swollen face or throat, or difficulty breathing. If these occur, seek immediate medical attention.
Allergy shots: Stelara (Ustekinumab) may affect allergy shots. If you are receiving or have received allergy shots, especially for severe allergic reactions, discuss with your doctor how Stelara (Ustekinumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Stelara (Ustekinumab), and whether any special monitoring is needed.
Immune system and infections: Stelara (Ustekinumab) may lower your ability to fight infections and may increase the risk of infections and reactivate inactive infections. Your doctor may test for tuberculosis before starting Stelara (Ustekinumab).
Your doctor will do regular tests of immune system function while you are using Stelara (Ustekinumab). If you develop a severe infection, contact your doctor as soon as possible.
Latex: The needle cover on the pre-filled syringe contains dry natural rubber (a form of latex). If you are allergic to latex, talk to your doctor before using the pre-filled syringe.
Malignancies (cancer): Stelara (Ustekinumab) may increase the risk of cancer. If you have cancer or have had cancer in the past, discuss with your doctor how Stelara (Ustekinumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Stelara (Ustekinumab), and whether any special monitoring is needed.
Reversible posterior leukoencephalopathy syndrome (RPLS): This is a rare disease of the brain that may occur when using medications like Stelara (Ustekinumab). If you have had a previous episode of RPLS, Stelara (Ustekinumab) may not be an appropriate medication for you. Make sure your doctor knows you have experienced this before. If you experience signs and symptoms of RPLS, such as headache, seizures, change in awareness or consciousness or vision changes, contact your doctor immediately.
Serious infections: Stelara (Ustekinumab) can affect the way your body's natural defences work to fight infection. This makes the body more likely to develop infections due to bacteria, viruses, and fungi. This effect is increased if you are taking Stelara (Ustekinumab) with other medications that reduce the body's ability to fight infection. For some people, these infections have been fatal. If you have a history of chronic or frequent infections, discuss with your doctor how Stelara (Ustekinumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Stelara (Ustekinumab), and whether any special monitoring is needed.
Stop taking the medication and tell your doctor right away if you notice symptoms of a serious infection, such as fever, chills, headache, flu-like symptoms, feeling tired, cough, blood in the sputum, shortness of breath, night sweats, weight loss, nausea, vomiting, diarrhea, frequency of urination or burning while passing urine, redness or swelling of skin or joint, Cold Sores, tooth pain, or new or worsening pain in any part of the body.
If you have an active infection, you should not use Stelara (Ustekinumab) until the infection resolves.
Serious skin conditions: Some people receiving Stelara (Ustekinumab) have reported rare serious skin conditions (exfoliative dermatitis and erythrodermic psoriasis). If you experience redness and shedding of skin over most of the body, contact your doctor immediately.
Tuberculosis: Some people who have had tuberculosis (a lung infection) in the past have had this infection return when they are using Stelara (Ustekinumab). If you have a history of tuberculosis, or have come into recent contact with someone who has tuberculosis, discuss with your doctor how Stelara (Ustekinumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Stelara (Ustekinumab), and whether any special monitoring is needed.
Vaccinations: People taking Stelara (Ustekinumab) should not receive certain vaccines. Talk to your doctor about whether any vaccines you are scheduled to take may be used with Stelara (Ustekinumab).
Pregnancy: Stelara (Ustekinumab) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using Stelara (Ustekinumab), contact your doctor immediately.
Breast-feeding: It is not known if Stelara (Ustekinumab) passes into breast milk. If you are breast-feeding and are taking Stelara (Ustekinumab), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Stelara (Ustekinumab) have not been established for children 6 years of age and younger with plaque psoriasis. The safety and effectiveness of using Stelara (Ustekinumab) have not been established for children less than 18 years of age with psoriatic arthritis, Crohn's disease, or ulcerative colitis.
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All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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