Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Remodulin (Treprostinil). If you are concerned about side effects, discuss the risks and benefits of Remodulin (Treprostinil) with your doctor.

The following side effects have been reported by at least 1% of people taking Remodulin (Treprostinil). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Diarrhea
• dizziness
• fluid retention
• flushing
• headache
• hypotension (Low Blood Pressure)
• jaw pain
• loss of appetite
• nausea
• pain at the site of infusion
• rash
• redness or rash at the site of infusion

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• bruising
• fainting
• numbness
• swelling
• symptoms of an intravenous line infection (e.g., redness, tenderness, swelling, or pus at the infusion site)

Seek immediate medical attention if any of the following occur:

• sudden onset of Fever
• symptoms of a blood infection (e.g., fever, headache, fatigue)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Remodulin (Treprostinil).

1 mg/mL
Each mL of Remodulin Injection, 1 mg/mL, contains 1 mg of Remodulin (Treprostinil) (as Remodulin (Treprostinil) sodium). Nonmedicinal ingredients: sodium citrate, sodium chloride, metacresol, sodium hydroxide, and water for injection. Hydrochloric acid and sodium hydroxide may have been added to adjust pH.

2.5 mg/mL
Each mL of Remodulin Injection, 2.5 mg/mL, contains 2.5 mg of Remodulin (Treprostinil) (as Remodulin (Treprostinil) sodium). Nonmedicinal ingredients: sodium citrate, sodium chloride, metacresol, sodium hydroxide, and water for injection. Hydrochloric acid and sodium hydroxide may have been added to adjust pH.

5 mg/mL
Each mL of Remodulin Injection, 5 mg/mL, contains 5 mg of Remodulin (Treprostinil) (as Remodulin (Treprostinil) sodium). Nonmedicinal ingredients: sodium citrate, sodium chloride, metacresol, sodium hydroxide, and water for injection. Hydrochloric acid and sodium hydroxide may have been added to adjust pH.

10 mg/mL
Each mL of Remodulin Injection, 10 mg/mL, contains 10 mg of Remodulin (Treprostinil) (as Remodulin (Treprostinil) sodium). Nonmedicinal ingredients: sodium citrate, sodium chloride, metacresol, sodium hydroxide, and water for injection. Hydrochloric acid and sodium hydroxide may have been added to adjust pH.

Do not use Remodulin (Treprostinil) if you are allergic to Remodulin (Treprostinil), any medications with a similar chemical structure to the medication, or any ingredients of the medication.

There may be an interaction between Remodulin (Treprostinil) and any of the following:

• acetylsalicylic acid (Asa)
• alcohol
• Alfuzosin
• alpha agonists (e.g., Clonidine, methyldopa)
• angiotensin converting enzyme inhibitors (ACEIs; Captopril, Ramipril)
• angiotensin receptor blockers (ARBs; e.g., Candesartan, Irbesartan, Losartan)
• antiarrhythmics (e.g., Amiodarone, Dipyridamole, Disopyramide, Flecainide, procainamide, quinidine)
• anti-psychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Apixaban
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Celecoxib
• chloroquine
• dabigatran
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• Domperidone
• Edoxaban
• Gemfibrozil
• Heparin
• herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
• Hydralazine
• low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Methadone
• mifepristone
• nitrates (e.g., isosorbide dinitrate, Nitroglycerin)
• non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
• Phenytoin
• Prasugrel
• primidone
• protein kinase inhibitors (e.g., Lapatinib, Pazopanib, Sunitinib)
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Ofloxacin,
• ritonavir
• saquinavir
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
• Tetrabenazine
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Remodulin (Treprostinil). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Remodulin (Treprostinil).

Infection: Since Remodulin (Treprostinil) is given intravenously and usually for a long period of time through a central venous catheter, this increases your risk of infections in the blood, which can be fatal.

If you notice any signs or symptoms such as a sudden onset of fever, fatigue, or headache, contact your doctor immediately. Giving the medication intravenously also puts you at increased risk of infections at the infusion site. Contact your doctor as soon as possible if you notice symptoms such as redness, tenderness, swelling, or pus at the infusion site.

Kidney or liver disease: If you have kidney or liver disease, discuss with your doctor how Remodulin (Treprostinil) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Remodulin (Treprostinil), and whether any special monitoring is needed.

Stopping the medication: Stopping Remodulin (Treprostinil) abruptly or sudden large decreases in the dose can result in symptoms of pulmonary hypertension such as pain when breathing (dyspnea), dizziness, weakness, and fatigue. If your Remodulin (Treprostinil) is stopped abruptly for some reason and you develop these symptoms, contact your doctor immediately.

Pregnancy: Remodulin (Treprostinil) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Remodulin (Treprostinil), contact your doctor immediately.

Breast-feeding: It is not known if Remodulin (Treprostinil) passes into breast milk. If you are a breast-feeding mother and are taking Remodulin (Treprostinil), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Remodulin (Treprostinil) have not been established for children under 16 years of age.

Seniors: The safety and effectiveness of using Remodulin (Treprostinil) have not been established for people above 65 years of age.