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Desvenlafaxine belongs to the class of antidepressant medications known as selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It is used to treat Depression.
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It works on the central nervous system (CNS) to elevate mood by increasing the amount of 2 neurotransmitters (chemical messengers) called serotonin and norepinephrine that are available in certain parts of the brain. It may take several weeks before the full benefits of Apo Desvenlafaxine are seen.
Apo Desvenlafaxine may be available under multiple brand names and/or in several different forms. Any specific brand name of Apo Desvenlafaxine may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Desvenlafaxine may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking Apo Desvenlafaxine without consulting your doctor.
Do not give Apo Desvenlafaxine to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
The recommended starting dose of desvenlafaxine for adults is 50 mg once daily at approximately the same time each day. If necessary, your doctor may increase your dose to a maximum of 100 mg daily.
Desvenlafaxine may be taken with or without food. Apo Desvenlafaxine must be swallowed whole with fluid. Do not divide, crush, chew, or dissolve Apo Desvenlafaxine before swallowing it.
When taking Apo Desvenlafaxine, you may see something in your stool that looks like a tablet. This is the empty shell after the medication has been absorbed by your body.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Apo Desvenlafaxine at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Apo Desvenlafaxine. If you are concerned about side effects, discuss the risks and benefits of Apo Desvenlafaxine with your doctor.
The following side effects have been reported by at least 1% of people taking Apo Desvenlafaxine. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Desvenlafaxine.
50 mg Each light pink, rounded-square-shaped, biconvex, film-coated tablet, engraved with "APO" on one side and "DV" over "50" on the other side, contains 50 mg of desvenlafaxine (as base). Nonmedicinal ingredients: anhydrous citric acid, colloidal silicon dioxide, euroxide red iron oxide, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide, and yellow iron oxide.
100 mg Each reddish-orange, rounded-square-shaped, biconvex, film-coated tablet, engraved with "APO" on one side and "DV" over "100" on the other side, contains 100 mg of desvenlafaxine (as base). Nonmedicinal ingredients: anhydrous citric acid, colloidal silicon dioxide, euroxide red iron oxide, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide, and red iron oxide.
Do not take desvenlafaxine if you:
There may be an interaction between desvenlafaxine and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Apo Desvenlafaxine. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Desvenlafaxine.
Abnormal bleeding: There have been some reports of abnormal bleeding associated with desvenlafaxine. The risk of bleeding may be increased by other medications that affect bleeding (e.g., Ibuprofen, Naproxen, acetylsalicylic acid [Asa], Warfarin). If you notice unusual bleeding or bruising, contact your doctor right away. If you have a bleeding disorder, discuss with your doctor how Apo Desvenlafaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Blood pressure: Treatment with desvenlafaxine may increase blood pressure. People with high blood pressure should have their blood pressure controlled before taking Apo Desvenlafaxine. Your doctor will check your blood pressure regularly while you are taking Apo Desvenlafaxine.
Bone fractures: Medications in the same class as desvenlafaxine have been reported to increase the risk for bone fractures. If you have Osteoporosis or are at risk for developing osteoporosis, or have had a recent bone fracture, discuss with your doctor how Apo Desvenlafaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Desvenlafaxine, and whether any special monitoring is needed.
Cholesterol: Apo Desvenlafaxine may increase cholesterol and triglyceride levels. Your doctor may monitor these levels while you are taking Apo Desvenlafaxine. If you have High Cholesterol or triglyceride levels, discuss with your doctor how Apo Desvenlafaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Drowsiness/reduced alertness: If you are taking desvenlafaxine, do not drive a car or perform hazardous tasks until you have determined that Apo Desvenlafaxine does not impair your ability to perform these tasks safely.
Glaucoma: Apo Desvenlafaxine may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Apo Desvenlafaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking Apo Desvenlafaxine.
Heart and other blood vessel disease: If you have heart disease or blood vessel disease in the brain (e.g., history of a Stroke), discuss with your doctor how Apo Desvenlafaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Kidney function: Reduced kidney function or Kidney Disease may cause Apo Desvenlafaxine to build up in the body, causing side effects. If you have reduced kidney function, discuss with your doctor how Apo Desvenlafaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Desvenlafaxine, and whether any special monitoring is needed.
Low sodium levels: Apo Desvenlafaxine may cause low sodium levels, especially for seniors, people who are dehydrated, and people taking diuretics (water pills). Contact your doctor if you notice symptoms of low sodium such as confusion, concentration or memory problems, weakness, or unsteadiness.
Lung problems: Rarely, some people taking Apo Desvenlafaxine may develop certain lung problems or infections. These can become serious very quickly. If you notice any coughing, difficulty breathing, or chest discomfort while taking desvenlafaxine, see your doctor as soon as possible.
Mania or bipolar disorder: Apo Desvenlafaxine may activate mania. If you have a history of mania or bipolar disorder, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Desvenlafaxine, and whether any special monitoring is needed.
Narrowing or blockage of the gastrointestinal tract: This medication should not be taken by people who have narrowing or blockage of the gastrointestinal tract (esophagus, stomach, intestines) due to medical conditions such as "short gut" syndrome, Cystic Fibrosis, or inflammatory bowel disease (e.g., Ulcerative Colitis).
Seizures: As with other antidepressants, Apo Desvenlafaxine may increase the risk of seizures. If you have had seizures in the past, discuss with your doctor how Apo Desvenlafaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Serotonin syndrome or neuroleptic malignant syndrome: This medication may cause the rare but potentially life-threatening conditions called serotonin syndrome or neuroleptic malignant syndrome, especially when used with other medications that increase serotonin levels (e.g., Sumatriptan, Rizatriptan, Tramadol, St. John's wort). Get immediate medical attention if you experience symptoms such as:
Stopping the medication: Stopping Apo Desvenlafaxine suddenly may lead to unwanted symptoms such as:
Although these symptoms usually go away without treatment, tell your doctor if you experience any of these symptoms. When Apo Desvenlafaxine is stopped, it should be stopped gradually as directed by your doctor.
Suicidal or agitated behaviour: People taking antidepressants such as desvenlafaxine may feel agitated (restless, anxious, aggressive, emotional, trouble sleeping, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within the first few weeks of starting Apo Desvenlafaxine. If you notice any changes in mood, behaviours, thoughts, or feelings in yourself or someone who is taking Apo Desvenlafaxine, contact a doctor immediately. Your doctor will monitor you closely for behaviour changes, especially at start of treatment or when your dose is increased or decreased.
Pregnancy: Newborns whose mothers take medications such as desvenlafaxine during the third trimester of pregnancy may experience complications that require prolonged hospitalization. These complications normally resolve over time.
Apo Desvenlafaxine should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Apo Desvenlafaxine, contact your doctor immediately. Do not stop taking Apo Desvenlafaxine without talking to your doctor. If Apo Desvenlafaxine is stopped, it should be stopped gradually as directed by your doctor.
Breast-feeding: Apo Desvenlafaxine passes into breast milk. If you are a breast-feeding mother and are taking desvenlafaxine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and efficacy of using this medication have not been established for children less than 18 years of age. The use of Apo Desvenlafaxine by children less than 18 years old may cause behavioural and emotional changes, such as suicidal thoughts and behaviour.
Seniors: Seniors may be more likely to experience side effects, especially increased blood pressure, with Apo Desvenlafaxine than younger adults. Lower doses may be needed.
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