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Granisetron belongs to the class of medications called 5-HT3 receptor antagonists. Granisetron is used to prevent nausea and vomiting associated with particular types of cancer chemotherapy and radiation therapy.
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Granisetron belongs to the class of medications called 5-HT3 receptor antagonists. Granisetron is used to prevent nausea and vomiting associated with particular types of cancer chemotherapy and radiation therapy. It works by reducing the effects of a naturally-occurring chemical in the body called serotonin, which causes nausea and vomiting.
Granisetron may be available under multiple brand names and/or in several different forms. Any specific brand name of Granisetron may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Granisetron may not be used for all of the conditions discussed here.
Your doctor may have suggested Granisetron for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Granisetron, speak to your doctor. Do not stop taking Granisetron without consulting your doctor.
Do not give Granisetron to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Granisetron if their doctor has not prescribed it.
Chemotherapy: The recommended adult dose of granisetron is 2 mg on the day of chemotherapy. This can be taken as one dose of 2 mg one hour before chemotherapy, or as 2 doses of 1 mg with the first dose one hour before chemotherapy and the second dose 12 hours after chemotherapy.
Radiation: The recommended adult dose of granisetron is 2 tablets (2 mg) taken one hour before radiation treatment.
Granisetron can be given intravenously (in the vein) as an injection if you are unable to swallow or are vomiting too much. In this case, the dose is based on body weight. The recommended adult dose is calculated as 10 µg per kilogram of body weight and is given within 30 minutes of starting chemotherapy. The intravenous form of Granisetron will be prepared and given to you by a health care provider in a clinic or hospital setting.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones above, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Granisetron exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Granisetron at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Granisetron. If you are concerned about side effects, discuss the risks and benefits of Granisetron with your doctor.
The following side effects have been reported by at least 1% of people taking Granisetron. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Granisetron.
Granisetron Hydrochloride Injection by Sandoz is no longer being manufactured for sale in Canada. For brands that may still be available, search under granisetron. This article is being kept available for reference purposes only. If you are using Granisetron, speak with your doctor or pharmacist for information about your treatment options.
Do not take granisetron if you:
There may be an interaction between granisetron and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Granisetron. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Granisetron.
Drowsiness/reduced alertness: There have been occasional reports of drowsiness by people who have taken granisetron. Avoid operating motor vehicles or doing other potentially hazardous activities until you determine the how Granisetron affects you.
Heart rhythm: Granisetron, like other medications in the same family, can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death. If you are at risk for heart rhythm problems (e.g., people with heart failure, Angina, low potassium or magnesium levels), discuss with your doctor how Granisetron may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Granisetron, and whether any special monitoring is needed.
Galactose intolerance/glucose malabsorption: Granisetron tablets are prepared with lactose. If you have lactose or galactose intolerance you should not take these medications.
Liver function: Liver disease or reduced liver function may cause Granisetron to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Granisetron may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Granisetron, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Granisetron.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Serotonin Syndrome: Severe reactions are possible when granisetron is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat Depression.
If you are taking antidepressants, discuss with your doctor how Granisetron may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Granisetron, and whether any special monitoring is needed.
If you experience symptoms of a reaction, such as muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation, get immediate medical attention. Coma and death are possible.
Pregnancy: The safety of granisetron for use by pregnant women has not been established. Granisetron is not recommended for use during pregnancy. If you become pregnant while taking Granisetron, contact your doctor immediately.
Breast-feeding: It is not known if granisetron passes into breast milk. If you are a breast-feeding mother and are taking Granisetron, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of granisetron have not been established for children or adolescents under 18 years of age. Its use by this age group is not recommended.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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