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Risedronate belongs to a group of medications called bisphosphonates. It is used to treat and prevent Osteoporosis for women who are past Menopause, and to treat and prevent osteoporosis caused by treatment with corticosteroids (e.
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Risedronate belongs to a group of medications called bisphosphonates. It is used to treat and prevent Osteoporosis for women who are past Menopause, and to treat and prevent osteoporosis caused by treatment with corticosteroids (e.g., Prednisone) for men and women. It is also used to improve bone mineral density for men with osteoporosis, and to treat a condition called Paget's disease. The long-acting form of risedronate is used only to treat osteoporosis in women who are past menopause.
Risedronate increases the thickness of bone (bone mineral density) by slowing down the cells that usually break down bone (osteoclasts). This allows the cells that build bone (osteoblasts) to work more efficiently. By making bones stronger, risedronate can help to reduce the incidence of osteoporosis-related fractures.
Risedronate may be available under multiple brand names and/or in several different forms. Any specific brand name of Risedronate may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Risedronate may not be used for all of the conditions discussed here.
Your doctor may have suggested Risedronate for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Risedronate, speak to your doctor. Do not stop taking Risedronate without consulting your doctor.
Do not give Risedronate to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Risedronate if their doctor has not prescribed it.
For preventing osteoporosis in women who are past menopause, the recommended dose of risedronate is 5 mg once daily or 35 mg once weekly.
For treating osteoporosis in women who are past menopause, there are multiple schedules for taking risedronate. It may be taken 5 mg once daily, 35 mg once weekly, 75 mg on 2 consecutive days per month on the same calendar days each month, or 150 mg once a month on the same calendar day each month.
For treating osteoporosis in men, the recommended dose of risedronate is 35 mg once weekly.
For treating and preventing osteoporosis caused by treatment with corticosteroids, the recommended dose of risedronate is 5 mg daily.
For treating Paget's disease, the recommended dose is 30 mg once daily for 2 months.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Risedronate exactly as prescribed by your doctor.
The tablet should be taken with plain water at least 30 minutes before the first food or drink of the day. It may also be taken at least 2 hours after any food or drink other than plain water. Do not eat or drink for 2 hours before and for at least 30 minutes after taking the tablet.
All strengths of risedronate should be taken while sitting in an upright position and swallowed whole (not chewed) with at least a half glass of water (i.e., at least 120 mL). Do not lie down for at least 30 minutes after taking the medication to prevent any irritation to your esophagus (the tube connecting the mouth and stomach).
If you are taking calcium supplements or aluminum-, iron-, or magnesium-containing medications (e.g., antacids and mineral supplements), you should take them at a different time of day. When taken together with risedronate, they will decrease the amount of risedronate that is delivered from your stomach into your body and reduce the effectiveness of the risedronate.
If you are taking Risedronate on a once-daily schedule and then miss a dose, do not take it later in the day. Resume your usual schedule the next morning. Do not take 2 doses at the same time.
If you are taking Risedronate on a once-weekly basis and you forget to take it on the regularly scheduled day, take one tablet on the day you first remember. Then, return to taking one tablet once a week on your regularly scheduled day. Do not take 2 tablets on the same day.
If you are taking Risedronate on a twice-monthly basis (schedule of 2 doses on 2 consecutive days per month) and miss a dose and the next month's scheduled doses are more than 7 days away, take the missed tablet in the morning after the day it is remembered. If both tablets are missed, take one tablet in the morning after the day it is remembered and the second tablet on the next consecutive morning. If you remember the missed dose and are within 7 days of the next month's scheduled doses, skip the missed dose(s), and wait until the next month's scheduled dose to continue.
If you are taking Risedronate on a once-monthly basis and miss a dose and the next month's scheduled dose is more than 7 days away, take the missed dose in the morning after the day it is remembered. If a dose is missed within 7 days of the next month's scheduled dose, skip the missed dose and wait until the next month's scheduled dose to continue.
Store Risedronate at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Risedronate. If you are concerned about side effects, discuss the risks and benefits of Risedronate with your doctor.
The following side effects have been reported by at least 1% of people taking Risedronate. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Risedronate.
Each oval, orange-coated tablet debossed with "RS" on one side and "35" on the other contains the equivalent of 35 mg of anhydrous risedronate sodium in the form of the hemipentahydrate with small amounts of monohydrate. Nonmedicinal ingredients: colloidal silicon dioxide, red iron oxide, iron oxide yellow, maltodexterin, mannitol, polyvinyl alcohol-polyethylene glycol graft copolymer, povidone, pregelatinized starch, sodium starch glycolate, sodium stearyl fumarate, sucrose, talc, titaniun dioxide, and triethyl citrate.
Do not take risedronate if you:
There may be an interaction between risedronate and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Risedronate. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Risedronate.
Atypical femur fracture: There is evidence that long-term use of this class of medication may contribute to a type of rare fracture of the long bone in the thigh (femur) without any form of trauma.
If you experience new or unusual pain in the groin, hip, or thigh area, contact your doctor as soon as possible.
Bone, joint, and muscle problems: On rare occasions, people taking Risedronate experience severe bone, joint, or muscle pain. This pain usually goes away when the medication is stopped.
Calcium and vitamin D: Calcium and vitamin D are important contributors to bone growth and strength. It may be necessary to take calcium or vitamin D supplements to get the best effect from risedronate if you are not getting enough from your diet. Your doctor may test you for low calcium levels or vitamin D deficiency before you start taking risedronate.
Effects on the esophagus: Risedronate can cause irritation or ulcers of the esophagus (the passage from the throat to the stomach). In some cases, these effects have been severe and have required hospitalization. Stop taking the medication and contact your doctor immediately if you suddenly experience problems swallowing, find it painful to swallow, develop pain behind the sternum (breastbone), or have new or worsening heartburn.
To reduce the risk of irritation of the esophagus, swallow Risedronate with a full glass of plain water first thing in the morning when you get up. Do not lie down until 30 minutes have passed and you have eaten your first food of the day. Do not chew or suck on the tablet, as this may lead to ulcers in the mouth or throat. Do not take Risedronate at bedtime or before getting up for the day.
Effects on the stomach and intestines: Rarely, people taking Risedronate have developed ulcers of the stomach or intestines. Get immediate medical attention if you have symptoms of a stomach or intestinal ulcer, such as nausea, vomiting, abdominal pain, loss of weight or appetite, black or bloody stools, or vomiting blood.
If you have a history of ulcer or other stomach problems, discuss with your doctor how Risedronate may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Risedronate, and whether any special monitoring is needed.
Inflammation of the eye: Conditions of eye inflammation have been reported by people using risedronate. If you experience changes to your vision, red eyes, or eye pain, contact your doctor as soon as possible.
Jaw problems: Rarely, risedronate can cause severe jaw problems associated with delayed healing and infection, especially in people with cancer or after tooth extractions. Your doctor may ask you to see your dentist before you start taking Risedronate. Any necessary dental procedures should be completed before starting treatment with risedronate. It is important that you take good care of your teeth and gums while taking Risedronate. If you experience any mouth sores or pain in the jaw or teeth, contact your doctor as soon as possible.
Kidney function: Risedronate is removed from the body by the kidneys. Decreased kidney function may cause an increase in the amount of medication in the body, causing side effects. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Risedronate may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Risedronate, and whether any special monitoring is needed.
Risedronate is not recommended for use by people with severely reduced kidney function.
People who cannot stand or sit upright for at least 30 minutes: Risedronate can cause irritation or ulcers of the esophagus (the tube connecting the mouth and stomach). People who cannot stand or sit upright for at least 30 minutes should use risedronate only if the benefits outweigh the risks.
Pregnancy: Risedronate is not intended for use during pregnancy. If you become pregnant while taking Risedronate, contact your doctor immediately.
Breast-feeding: It is not known if risedronate passes into breast milk. Risedronate is not intended for use by women who are breast-feeding. If you are a breast-feeding mother and are taking Risedronate, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Risedronate have not been established for children.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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