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Avastin (Bevacizumab) belongs to a group of cancer-fighting medications called antineoplastics, and specifically to the group of antineoplastics called biological response modifiers. It is used in combination with certain types of chemotherapy medications to treat colon or rectal cancer that has spread to other parts of the body.
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Avastin (Bevacizumab) belongs to a group of cancer-fighting medications called antineoplastics, and specifically to the group of antineoplastics called biological response modifiers. It is used in combination with certain types of chemotherapy medications to treat colon or rectal cancer that has spread to other parts of the body. While chemotherapy directly attacks a tumour, Avastin (Bevacizumab) works by stopping the tumour from forming new blood vessels.
Avastin (Bevacizumab) can also be used in combination with chemotherapy to treat certain types of lung and Brain Cancer. When combined with specific types of chemotherapy, it can be used for certain ovarian, fallopian, and peritoneal cancers.
Avastin (Bevacizumab) has been granted a notice of compliance (meaning available for use on the Canadian market) with conditions (NOC/c) by Health Canada to be used on its own for treatment of a type of brain cancer called glioblastoma. This means that Health Canada has approved Avastin (Bevacizumab) to be marketed based on promising evidence of effectiveness, but additional results of studies are needed to verify its effectiveness. An NOC/c is used to allow access to products that are used for the treatment or prevention of serious, life-threatening, or severely debilitating illness.
Avastin (Bevacizumab) may be available under multiple brand names and/or in several different forms. Any specific brand name of Avastin (Bevacizumab) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Avastin (Bevacizumab) may not be used for all of the conditions discussed here.
Your doctor may have suggested Avastin (Bevacizumab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Avastin (Bevacizumab), speak to your doctor.
Do not give Avastin (Bevacizumab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Avastin (Bevacizumab) if their doctor has not prescribed it.
The recommended adult dose of Avastin (Bevacizumab) is based on body weight and given as an intravenous infusion by your doctor. The dose and frequency depend on the type of cancer that the medication is being used to treat. The first dose should be given slowly over 90 minutes, and if the side effects are acceptable, the second dose can be given over 60 minutes. If the side effects are still acceptable, future infusions can be given over 30 minutes.
Very careful handling of Avastin (Bevacizumab) is required, and it is always given in a hospital or similar setting with access to sterile equipment for preparation.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. It is important Avastin (Bevacizumab) be given exactly as recommended by your doctor. If you miss an appointment to receive Avastin (Bevacizumab), contact your doctor as soon as possible to reschedule your appointment.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
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Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Avastin (Bevacizumab). If you are concerned about side effects, discuss the risks and benefits of Avastin (Bevacizumab) with your doctor.
The following side effects have been reported by at least 1% of people taking Avastin (Bevacizumab). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop using the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Avastin (Bevacizumab).
Each vial contains Avastin (Bevacizumab) 25 mg/mL as either Avastin (Bevacizumab) 100 mg in 4 mL or Avastin (Bevacizumab) 400 mg in 16 mL. Nonmedicinal ingredients: α,α-trehalose dihydrate, polysorbate 20, sodium phosphate and water for injection. Preservative-free.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
December 18, 2023
December 14, 2023
August 8, 2022