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Available Form:   Injectable
Manufacturer name:   Hoffmann-La Roche
Generic name:   bevacizumab
Strength:   25mg/ml

What is Avastin?

Avastin (Bevacizumab) belongs to a group of cancer-fighting medications called antineoplastics, and specifically to the group of antineoplastics called biological response modifiers. It is used in combination with certain types of chemotherapy medications to treat colon or rectal cancer that has spread to other parts of the body.

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Avastin How to Take

Avastin (Bevacizumab) belongs to a group of cancer-fighting medications called antineoplastics, and specifically to the group of antineoplastics called biological response modifiers. It is used in combination with certain types of chemotherapy medications to treat colon or rectal cancer that has spread to other parts of the body. While chemotherapy directly attacks a tumour, Avastin (Bevacizumab) works by stopping the tumour from forming new blood vessels.

Avastin (Bevacizumab) can also be used in combination with chemotherapy to treat certain types of lung and Brain Cancer. When combined with specific types of chemotherapy, it can be used for certain ovarian, fallopian, and peritoneal cancers.

Avastin (Bevacizumab)  has been granted a notice of compliance (meaning available for use on the Canadian market) with conditions (NOC/c) by Health Canada to be used on its own for treatment of a type of brain cancer called glioblastoma. This means that Health Canada has approved Avastin (Bevacizumab) to be marketed based on promising evidence of effectiveness, but additional results of studies are needed to verify its effectiveness. An NOC/c is used to allow access to products that are used for the treatment or prevention of serious, life-threatening, or severely debilitating illness.

Avastin (Bevacizumab) may be available under multiple brand names and/or in several different forms. Any specific brand name of Avastin (Bevacizumab) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Avastin (Bevacizumab) may not be used for all of the conditions discussed here.

Your doctor may have suggested Avastin (Bevacizumab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Avastin (Bevacizumab), speak to your doctor.

Do not give Avastin (Bevacizumab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Avastin (Bevacizumab) if their doctor has not prescribed it.

Automatic Refills

We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.

Avastin Dosage

The recommended adult dose of Avastin (Bevacizumab) is based on body weight and given as an intravenous infusion by your doctor. The dose and frequency depend on the type of cancer that the medication is being used to treat. The first dose should be given slowly over 90 minutes, and if the side effects are acceptable, the second dose can be given over 60 minutes. If the side effects are still acceptable, future infusions can be given over 30 minutes.

Very careful handling of Avastin (Bevacizumab) is required, and it is always given in a hospital or similar setting with access to sterile equipment for preparation.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. It is important Avastin (Bevacizumab) be given exactly as recommended by your doctor. If you miss an appointment to receive Avastin (Bevacizumab), contact your doctor as soon as possible to reschedule your appointment.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Avastin Side Effects

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Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Avastin (Bevacizumab). If you are concerned about side effects, discuss the risks and benefits of Avastin (Bevacizumab) with your doctor.

The following side effects have been reported by at least 1% of people taking Avastin (Bevacizumab). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • changes in taste sensation
  • Constipation
  • Diarrhea
  • dry, scaly skin or changes in skin colour
  • hoarseness
  • lack of energy or strength
  • loss of appetite
  • headache
  • mouth sores
  • nausea or vomiting
  • runny nose
  • trouble sleeping
  • unusual pain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • bleeding from the rectum (bright red blood with or without stools)
  • changes in blood or urine tests
  • high or Low Blood Pressure
  • high blood sugar (increased appetite, increased thirst, increased urination, weakness)
  • increased infections  (symptoms may include Fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • jaw pain
  • signs of Anemia (low red blood cells; e.g., dizziness,  pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of bleeding (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • signs of heart failure (e.g., feet or ankle swelling, fatigue when doing regular household activities, shortness of breath)
  • swelling of the hands or feet
  • tingling sensation in the fingers and toes
  • vision changes
  • weight loss
  • wounds that are slow to heal

Stop using the medication and seek immediate medical attention if any of the following occur:

  • chest pain that spreads to the arms, jaw, or back
  • loss of vision or blurred vision
  • pain, swelling, warmth, or tenderness in the leg
  • signs and symptoms of hypertensive encephalopathy, e.g.:
    • headache
    • nausea
    • seizures or confusion
    • very high blood pressure
    • vision problems
    • vomiting
  • signs of a rare neurological disorder called posterior reversible encephalopathy syndrome (PRES), e.g.:
    • confusion
    • dizziness
    • headache
    • high blood pressure
    • seizures
    • vision problems or blindness
  • sudden loss of speech or numbness in part or all of the body
  • sudden shortness of breath
  • sudden stomach pain or tenderness with constipation, vomiting, or high fever
  • symptoms of a serious allergic reaction, e.g.:
    • difficulty breathing
    • Hives
    • swelling of the face, tongue, or throat
  • unexplained dizziness or sudden falls
  • vomiting blood or coffee-ground-like substance

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Avastin (Bevacizumab).

Discreet Packaging

Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.

Avastin Available Form

Each vial contains Avastin (Bevacizumab) 25 mg/mL as either Avastin (Bevacizumab) 100 mg in 4 mL or Avastin (Bevacizumab) 400 mg in 16 mL. Nonmedicinal ingredients: α,α-trehalose dihydrate, polysorbate 20, sodium phosphate and water for injection. Preservative-free.

References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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