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Rosuvastatin

Rosuvastatin

Rosuvastatin belongs to the group of medications known as HMG CoA reductase inhibitors ("statins"). It is used, along with a healthy diet and exercise program, to improve cholesterol levels by lowering bad cholesterol and raising good cholesterol.

Available form

Tablet

Dosage

5mg, 10mg, 20mg, 40mg

Manufacturers

Accord Healthcare, Angita Pharma, Apotex, Auro Pharma, Biomedpharma, Dominion Pharmacal, Generic Medical Partners, Jamp Pharma Corporation, Laboratoire Riva, Mantra Pharma

Branded drugs

Crestor

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Rosuvastatin information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Directions of use

Before starting rosuvastatin, you should be following a cholesterol-lowering diet. If appropriate, a program of weight control and physical exercise should also be implemented.

The recommended dose of rosuvastatin ranges between 5 mg and 40 mg once daily. For most people, the usual recommended starting dose of rosuvastatin is 10 mg once daily. If necessary, the dose may be increased to a maximum of 40 mg daily. People who require the maximum dose of 40 mg per day should consult a specialist.

For children 10 to 17 years of age, who have inherited cholesterol disorders, the recommended starting dose is 5 mg taken once daily. Your doctor may increase this dose to a maximum of 10 mg daily, depending on the effectiveness of the medication and how well it is tolerated.

For people with severely reduced liver function, the maximum daily dose is 20 mg.

For people with severely reduced kidney function, the starting dose should be 5 mg daily and the maximum daily dose is 10 mg.

A starting dose of 5 mg daily is recommended for people of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin) and those who have severe kidney problems. This low dose should also be considered for people who do not need aggressive cholesterol-lowering effects and for people who may be at a greater risk of experiencing muscle-related problems.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Rosuvastatin may be taken in the morning or in the evening, with or without food.

It is very important that Rosuvastatin be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and carry on with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Rosuvastatin at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Rosuvastatin. If you are concerned about side effects, discuss the risks and benefits of Rosuvastatin with your doctor.

The following side effects have been reported by at least 1% of people taking Rosuvastatin. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Constipation
decreased sexual ability
difficulty sleeping
dizziness
headache
nausea
nightmares
stomach pain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

breast enlargement
confusion
Hives
itching
numbness, tingling, weakness, or pain in the hands or feet
persistent cough, with or without shortness of breath
poor memory
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
skin rash
symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
symptoms of liver damage (such as yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)
symptoms of muscle damage (unexplained muscle pain, tenderness or weakness, or brown or discoloured urine – especially if you also have a Fever or a general feeling of being unwell)
weakness

Stop taking the medication and seek immediate medical attention if any of the following occur:

difficulty swallowing or breathing
severe skin rash, including skin blistering and peeling (possibly with headache, fever, coughing, or aching before the rash begins)
signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
symptoms of a serious allergic reaction (such as swelling of the face or throat, hives, or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Rosuvastatin.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Rosuvastatin.

Alcohol: People who drink large quantities of alcohol should be closely monitored by their doctor while they are taking Rosuvastatin. The combination of alcohol and rosuvastatin increases the risk of developing liver problems.

Diabetes: Rosuvastatin, like other medications in this family, may cause an increase in blood sugar levels and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Rosuvastatin.

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Rosuvastatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Rosuvastatin, and whether any special monitoring is needed.

Hypersensitivity syndrome: A Anaphylaxis (severe allergic reaction) called hypersensitivity syndrome has occurred for some people with the use of "statin" cholesterol medication. Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.

Kidney function: If you have decreased kidney function or Kidney Disease, discuss with your doctor how Rosuvastatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Rosuvastatin, and whether any special monitoring is needed.

Liver function: Rosuvastatin may cause decreased liver function, including liver failure. Consuming alcohol can increase the risk of developing liver problems. Your doctor will perform regular blood tests to check your liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Do not use Rosuvastatin if you have active liver disease or have liver function tests that are higher than normal. If you have reduced liver function or a history of liver disease, discuss with your doctor how Rosuvastatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Rosuvastatin, and whether any special monitoring is needed.

Muscle damage: In rare cases, serious muscle damage has been associated with the use of "statin" medications, especially at higher doses. Before taking Rosuvastatin, tell your doctor or pharmacist if you:

are of Asian ancestry (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin)
are over the age of 70
are taking other cholesterol-lowering medication such as fibrates (e.g., gemfibrozil, fenofibrate) or niacin
are taking other medications (as drug interactions are possible), including prescription, non-prescription, and natural health products
do excessive physical exercise
have diabetes
have a family history of muscular disorders
have had any past problems with muscles (pain, tenderness) after taking a statin
have kidney or liver problems
have thyroid problems
have undergone surgery or other tissue injury
regularly drink 3 or more alcoholic drinks daily

Report any unexplained muscle pain, tenderness, weakness, cramps, or any brown or discoloured urine to your doctor immediately, particularly if you are also experiencing malaise (a general feeling of being unwell) or fever.

Pregnancy: Rosuvastatin should not be taken during pregnancy. If you become pregnant while taking Rosuvastatin, contact your doctor immediately.

Breast-feeding: It is not known if rosuvastatin passes into breast milk. If you are a breast-feeding mother and are taking Rosuvastatin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: There is limited experience with the use of Rosuvastatin by children. Rosuvastatin may be used by children between 10 and 17 years of age who have certain inherited cholesterol disorders. Girls should be at least 1 year past their first menstrual period. It should be used in addition to diet, when diet alone has not provided a satisfactory reduction in cholesterol levels. The safety and effectiveness of Rosuvastatin has not been established for children less than 10 years of age. If rosuvastatin is to be used by a child, the treatment should be supervised by a specialist.

Seniors: If you are older than 65 years of age, your doctor will likely monitor you closely for muscle-related side effects.

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