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Alecensaro (Alectinib) belongs to a group of cancer fighting medications called protein kinase inhibitors. It works by recognizing certain types of cancer cells and blocking the action of chemicals that cause them to divide and grow.
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Alecensaro (Alectinib) belongs to a group of cancer fighting medications called protein kinase inhibitors. It works by recognizing certain types of cancer cells and blocking the action of chemicals that cause them to divide and grow. This may slow down or stop cancers from growing and dividing.
Alecensaro (Alectinib) may be used to treat non-small cell Lung Cancer that is locally advanced and cannot be surgically removed or has spread to other parts of the body (metastasized) and is anaplastic lymphoma kinase (ALK)-positive.
Alecensaro (Alectinib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Alecensaro (Alectinib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Alecensaro (Alectinib) may not be used for all of the conditions discussed here.
Your doctor may have suggested Alecensaro (Alectinib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Alecensaro (Alectinib), speak to your doctor. Do not stop taking Alecensaro (Alectinib) without consulting your doctor.
Do not give Alecensaro (Alectinib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Alecensaro (Alectinib) if their doctor has not prescribed it.
The usual adult dose of Alecensaro (Alectinib) is 600 mg (four 150 mg capsules) taken by mouth, twice a day, with food. This provides a daily total of 1,200 mg of Alecensaro (Alectinib).
Swallow the capsules whole with some liquid. Do not open or dissolve the capsules to take them.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Alecensaro (Alectinib) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
If you vomit after taking a dose, take your next dose at the regularly scheduled time. Do not replace the vomited dose.
Store Alecensaro (Alectinib) at room temperature in its original package, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Alecensaro (Alectinib). If you are concerned about side effects, discuss the risks and benefits of Alecensaro (Alectinib) with your doctor.
The following side effects have been reported by at least 1% of people taking Alecensaro (Alectinib). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Alecensaro (Alectinib).
Each hard, white capsule, with "ALE" printed in black ink on the cap and "150 mg" printed in black ink on the body, contains 150 mg Alecensaro (Alectinib) (equivalent to 161.3 mg Alecensaro (Alectinib) hydrochloride). Nonmedicinal ingredients: carboxymethylcellulose calcium, hydroxypropylcellulose, lactose monohydrate, magnesium stearate, sodium lauryl sulfate; capsule shell: carnauba wax, carrageenan, corn starch, hypromellose, potassium chloride, titanium dioxide, and trace of printing ink.
Do not take Alecensaro (Alectinib) if you are allergic to Alecensaro (Alectinib) or any ingredients of the medication.
There may be an interaction between Alecensaro (Alectinib) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Alecensaro (Alectinib). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Alecensaro (Alectinib).
Heart disease: Alecensaro (Alectinib) can cause very low heart rate. If you have heart conditions with low heart rate such as certain types of arrhythmia, Congestive Heart Failure, sick sinus syndrome or certain types of heart block, discuss with your doctor how Alecensaro (Alectinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Alecensaro (Alectinib), and whether any special monitoring is needed.
If you experience signs of slow heartbeat, such as dizziness, lightheadedness and fainting, let your doctor know as soon as possible.
Gastrointestinal perforation: Rarely, people taking Alecensaro (Alectinib) experience a gastrointestinal perforation. This is a condition where a hole forms through the walls of the digestive tract and is a medical emergency. If you have risk factors for this type of complication, such as a history of Diverticulitis, cancer that has spread to the digestive tract or are taking other medications that may cause gastrointestinal perforation, discuss with your doctor how Alecensaro (Alectinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Alecensaro (Alectinib), and whether any special monitoring is needed.
Kidney function: Alecensaro (Alectinib) may cause decreased kidney function. If you experience signs of kidney problems, such as a change in the amount or colour of urine, increased urination at night, blood in the urine, or swelling in the feet or legs, contact your doctor.
Liver function: Liver disease or reduced liver function may cause Alecensaro (Alectinib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Alecensaro (Alectinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Alecensaro (Alectinib), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Alecensaro (Alectinib).
Alecensaro (Alectinib) may also cause harm to the liver. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Lung inflammation: Rarely, some people taking Alecensaro (Alectinib) have experienced lung inflammation (interstitial lung disease), causing difficulty breathing. This complication can be serious and sometimes fatal. If you experience new or worsening shortness of breath or cough (with or without fever) at any time while you are taking Alecensaro (Alectinib), contact your doctor immediately.
Muscle effects: Muscle damage has been associated with the use of Alecensaro (Alectinib). Report any unexplained muscle pain, tenderness, weakness or cramps, or any brown or discoloured urine to your doctor immediately, particularly if you are also experiencing malaise (a general feeling of being unwell) or fever.
Sensitivity to sunlight: Alecensaro (Alectinib) may increase the sensitivity of the skin to sunlight, increasing the risk of Sunburn. Avoid exposure to sunlight for long periods of time, particularly between the hours of 10 am and 2 pm, while you are taking Alecensaro (Alectinib) and for 7 days after completing treatment. Wear a broad-spectrum sunscreen and lip balm with an SPF of 50 or higher. If you notice any unusual skin rash or peeling, contact your doctor immediately.
Pregnancy: Alecensaro (Alectinib) should not be used during pregnancy unless the benefits outweigh the risks. Women of childbearing age who are taking Alecensaro (Alectinib) and women whose partners are taking Alecensaro (Alectinib) should use an effective method of birth control, such as condoms, during treatment and for at least 3 months after stopping the medication. If you become pregnant while taking Alecensaro (Alectinib), contact your doctor immediately.
Breast-feeding: It is not known if Alecensaro (Alectinib) passes into breast milk. If you are a breast-feeding mother and are taking Alecensaro (Alectinib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Alecensaro (Alectinib) have not been established for children.
Seniors: People over the age of 75 are more likely to experience severe side effects of taking Alecensaro (Alectinib).
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