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Tremfya (Guselkumab) belongs to the class of medications called selective immunomodulating agents, also known as biologics. Specifically, it is an interleukin-23 inhibitor.
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Tremfya (Guselkumab) belongs to the class of medications called selective immunomodulating agents, also known as biologics. Specifically, it is an interleukin-23 inhibitor. It is used to treat moderate-to-severe plaque psoriasis for adults who are candidates for phototherapy or systemic therapy. It is also used to treat adults with active Psoriatic Arthritis.
Tremfya (Guselkumab) works by blocking the action of the protein interleukin-23 in the body. If you have psoriasis, your body overproduces this protein.
Tremfya (Guselkumab) may be available under multiple brand names and/or in several different forms. Any specific brand name of Tremfya (Guselkumab) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Tremfya (Guselkumab) may not be used for all of the conditions discussed here.
Your doctor may have suggested Tremfya (Guselkumab) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Tremfya (Guselkumab), speak to your doctor. Do not stop taking Tremfya (Guselkumab) without consulting your doctor.
Do not give Tremfya (Guselkumab) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Tremfya (Guselkumab) if their doctor has not prescribed it.
The usual dose of Tremfya (Guselkumab) is 100 mg injected under the skin. After the first dose, the second dose is given in 4 weeks, and then every 8 weeks for subsequent doses.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Most people using Tremfya (Guselkumab) can be taught by a health care professional to give themselves the injection. Tremfya (Guselkumab) is used with the guidance and supervision of a doctor. Your doctor or nurse will assist you in the preparation and injection of your first dose (or first few doses). Do not attempt to inject Tremfya (Guselkumab) on your own until you completely understand how to inject a dose.
Before using Tremfya (Guselkumab), remove it from the refrigerator and allow it to warm to room temperature, with the cap on. This takes approximately 30 minutes. Do not shake Tremfya (Guselkumab). Shaking causes the medication to become less effective.
Follow the instructions from your doctor or pharmacist when administering the medication. The solution should be clear to slightly yellow and may contain tiny white or clear particles. Do not use the injection if it appears cloudy or discoloured, or if it has large particles floating in it.
Use a different site for each injection to decrease the risk of skin irritation. Dispose of your used needles in an appropriate sharps container.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Tremfya (Guselkumab) in the refrigerator, protect it from freezing, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Tremfya (Guselkumab). If you are concerned about side effects, discuss the risks and benefits of Tremfya (Guselkumab) with your doctor.
The following side effects have been reported by at least 1% of people taking Tremfya (Guselkumab). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tremfya (Guselkumab).
Each mL of sterile, clear-to-slightly-yellow solution for injection in a prefilled syringe contains 100 mg of Tremfya (Guselkumab). Nonmedicinal ingredients: L-histidine, L-histidine monohydrochloride monohydrate, sucrose, polysorbate 80, and water for injection.
Each mL of sterile, clear-to-slightly-yellow solution for injection in a patient-controlled injector contains 100 mg of Tremfya (Guselkumab). Nonmedicinal ingredients: L-histidine, L-histidine monohydrochloride monohydrate, sucrose, polysorbate 80, and water for injection.
Do not take Tremfya (Guselkumab) if you are allergic to Tremfya (Guselkumab) or any ingredients of the medication.
There may be an interaction between Tremfya (Guselkumab) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Tremfya (Guselkumab). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Tremfya (Guselkumab).
Infections: Tremfya (Guselkumab) can increase the risk of developing an infection, including serious infections such as sepsis, pneumonia, and Tuberculosis. Before starting Tremfya (Guselkumab) treatment, your doctor may test to see if you have tuberculosis. If you notice signs of an infection such as fever, chills, pain, swelling, coughing, or pus, contact your doctor as soon as possible. Tremfya (Guselkumab) should also not be started while you have an active infection.
Tell your doctor if you have a history of infections that keep coming back, or other conditions that might increase your risk of infections such as Diabetes. While you are taking Tremfya (Guselkumab), your doctor will monitor you for signs of infection.
Vaccinations: Vaccines that are given during treatment with Tremfya (Guselkumab) may not be as effective as expected. Also, people taking Tremfya (Guselkumab) should not receive certain vaccines. Talk to your doctor about whether any vaccines you are scheduled to take may be used with Tremfya (Guselkumab).
Pregnancy: Tremfya (Guselkumab) should not be used during pregnancy unless the benefits outweigh the risks. Women who may become pregnant should use effective birth control while taking Tremfya (Guselkumab) and for at least 12 weeks after the last dose of Tremfya (Guselkumab). If you become pregnant while taking Tremfya (Guselkumab), contact your doctor immediately.
Breast-feeding: It is not known if Tremfya (Guselkumab) passes into breast milk. If you are a breast-feeding mother and are taking Tremfya (Guselkumab), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Tremfya (Guselkumab) have not been established for children.
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