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What is Zaxine?

Rifaximin belongs to the class of medications called antibacterial agents. Specifically, it belongs to the family of rifamycin antibacterials.

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Rifaximin belongs to the class of medications called antibacterial agents. Specifically, it belongs to the family of rifamycin antibacterials. It is used in addition to Lactulose to reduce the risk of hepatic encephalopathy recurrence for adults. Hepatic encephalopathy is a condition that frequently develops when a person has chronic (long term) liver disease and the body is unable to easily get rid of the waste product, ammonia. The buildup of ammonia causes changes in brain function and may lead to coma or death if it is not controlled. Rifaximin is believed to work by eliminating bacteria in the digestive system that produce ammonia. It is very poorly absorbed into the rest of the body, making the digestive system the main area in which it works.

Rifaximin is also used to treat irritable bowel syndrome with Diarrhea. It is thought to work by reducing the amount of bacteria and bacterial products in the gut which can help improve symptoms of bloating, stomach pain, and diarrhea.

Zaxine may be available under multiple brand names and/or in several different forms. Any specific brand name of Zaxine may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Zaxine may not be used for all of the conditions discussed here.

Your doctor may have suggested Zaxine for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Zaxine, speak to your doctor. Do not stop taking Zaxine without consulting your doctor.

Do not give Zaxine to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Zaxine if their doctor has not prescribed it.



For the prevention of hepatic encephalopathy, the recommended adult dose of rifaximin is 550 mg taken 2 times a day.

For the treatment of irritable bowel syndrome with diarrhea, the recommended adult dosage is one tablet taken 3 times a day.

Rifaximin should be taken on an empty stomach. Tablets should be swallowed whole with water. Do not crush or chew rifaximin tablets.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Zaxine be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Zaxine at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Zaxine. If you are concerned about side effects, discuss the risks and benefits of Zaxine with your doctor.

The following side effects have been reported by at least 1% of people taking Zaxine. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • bloating
  • diarrhea (mild)
  • dizziness
  • headache
  • itchiness
  • nausea
  • reddish colour to sweat, urine, or tears
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal pain
  • muscle spasms
  • signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • skin rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of bowel inflammation (e.g., Fever that appears after starting the medication, watery and severe diarrhea [may also be bloody])
  • signs of a Anaphylaxis (severe allergic reaction) (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Zaxine.


Available form

Each pink, oval, biconvex tablet with "rfx" debossed on one side contains 550 mg of rifaximin. Nonmedicinal ingredients: colloidal silicon dioxide, glyceryl distearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, red iron oxide, sodium starch glycolate, talc, and titanium dioxide.



Do not take rifaximin if you:

  • are allergic to rifaximin or any ingredients of the medication
  • are allergic to any other rifamycin antibacterial medications



There may be an interaction between rifaximin and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Zaxine. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.



Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Zaxine.

Antibiotic-related diarrhea: As with other antibacterial medications, rifaximin can cause a severe form of diarrhea associated with a condition known as pseudomembranous colitis. If you develop severe diarrhea while taking (or within a few weeks of taking) Zaxine, contact your doctor.

Liver function: Liver disease or reduced liver function may cause Zaxine to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Zaxine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zaxine, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Zaxine.

Pregnancy: Zaxine should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Zaxine, contact your doctor immediately.

Breast-feeding: It is not known if rifaximin passes into breast milk. If you are a breast-feeding mother and are taking Zaxine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Zaxine have not been established for children.

Zaxine frequently asked questions

How To Buy Zaxine Online?

You can buy Zaxine online at PocketPills if you already have a valid prescription from your doctor. You can get started by uploading your prescription, ordering a refill by transferring any existing medications to our pharmacy or talking to one of our Canadian Doctors to get an online prescription. Get started now!

How To Get a Prescription for Zaxine?

You can consult a Canadian doctor online at Our physicians can prescribe medications online during your consultation. Once you receive a prescription, you'll have the option to have it delivered to your door in discreet packaging and at no additional cost!. Click here to get an online prescription today!

Can I Get Same-Day Delivery?

Yes! We do provide same-day delivery in select areas. We do next business day delivery and can also ship overnight as well.

How Much is Shipping Cost for Zaxine in Canada?

Shipping cost for Zaxine to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada and low dispensing fees to help you get access to treatment.

How to get Zaxine delivered to my home?

You could get Zaxine delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.

How to get Zaxine in Canada for free?

You can get Zaxine for free in Canada if your health insurance provider covers it fully. Contact your provider or us to help you find out if you qualify to get Zaxine for free.

Can I consult a doctor online to get Zaxine?

Yes. You can book a consultation online with a Canadian doctor here with us at PocketPills to see if you qualify for a prescription to order Zaxine.

Can I buy Zaxine without a prescription?

You need a valid prescription to buy Zaxine from us. Contact us if you need a prescription. One of our doctors can give you a telephone call at your convenience.


All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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