Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Trandolapril. If you are concerned about side effects, discuss the risks and benefits of Trandolapril with your doctor.

The following side effects have been reported by at least 1% of people taking Trandolapril. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• cough (dry, persistent)
• Diarrhea
• dizziness
• fatigue
• headache
• loss of appetite
• nasal stuffiness
• nausea
• unusual tiredness
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• confusion
• flu-like symptoms (sudden lack of energy, Fever, cough, sore throat)
• numbness or tingling in hands, feet, or lips
• signs of bleeding (e.g., unusual nosebleeds, blood in urine, coughing blood, bruising easily, cuts that won't stop bleeding)
• signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• signs of fluid and electrolyte imbalance (e.g., drowsiness, muscle pain or cramps, weakness, irregular heartbeat)
• signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of low blood pressure (e.g., dizziness, lightheadedness, fainting)
• signs of too much potassium in the body (e.g., confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; shortness of breath or difficulty breathing; weakness or heaviness of legs)
• skin rash, with or without itching, fever, or joint pain

Stop taking the medication and seek immediate medical attention if any of the following occur:

• abdominal pain, with or without nausea or vomiting
• signs of angioedema (e.g., swollen mouth, lips, tongue, difficulty swallowing or breathing)
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Trandolapril.

0.5 mg
Each size no. 2, hard gelatin capsule with a light scarlet opaque body and rich yellow opaque cap, contains 0.5 mg of trandolapril. Nonmedicinal ingredients: dimeticone, microcrystalline cellulose, lactose monohydrate, starch pregelatinized, colloidal silicon dioxide, magnesium stearate, and empty gelatin capsules; capsule: gelatin, titanium dioxide, erythrosine, sunset yellow, and quinoline yellow.

1 mg
Each size no. 2, hard gelatin capsule with a light scarlet opaque body and light orange opaque cap, contains 1 mg of trandolapril. Nonmedicinal ingredients: dimeticone, microcrystalline cellulose, lactose monohydrate, starch pregelatinized, colloidal silicon dioxide, magnesium stearate, and empty gelatin capsules; capsule: gelatin, titanium dioxide, erythrosine, and sunset yellow.

2 mg
Each size no. 2, hard gelatin capsule with a light scarlet opaque body and light scarlet opaque cap, contains 2 mg of trandolapril. Nonmedicinal ingredients: dimeticone, microcrystalline cellulose, lactose monohydrate, starch pregelatinized, colloidal silicon dioxide, magnesium stearate, and empty gelatin capsules; capsule: gelatin, titanium dioxide, erythrosine, and sunset yellow.

4 mg
Each size no. 2, hard gelatin capsule with a Swedish orange opaque body and Swedish orange opaque cap, contains 4 mg of trandolapril. Nonmedicinal ingredients: dimeticone, microcrystalline cellulose, lactose monohydrate, starch pregelatinized, colloidal silicon dioxide, magnesium stearate, and empty gelatin capsules; capsule: gelatin, titanium dioxide, erythrosine, red iron oxide, and yellow iron oxide.

Do not take trandolapril if you:

• are allergic to trandolapril or any ingredients of the medication
• are allergic to any other ACE inhibitors
• are pregnant or plan to become pregnant
• are breast-feeding
• are taking the medication sacubitril - Valsartan
• are taking the medication Aliskiren or another ACE inhibitor or an angiotensin receptor blocker (ARB) and have one of the following conditions:
• Diabetes
• Kidney Disease
• high levels of potassium in the blood
• have congestive heart failure combined with Low Blood Pressure
• have been diagnosed with hereditary angioedema
• have severely low blood pressure
• have any condition that makes you intolerant to lactose
• have had angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any other ACE inhibitors (e.g., Captopril, Ramipril)
• have narrowing of the blood vessels in the kidneys

There may be an interaction between trandolapril and any of the following:

• acetylsalicylic acid (Asa)
• alcohol
• Aldesleukin
• aliskiren
• Allopurinol
• alpha-agonists (e.g., Clonidine, methyldopa)
• alpha-blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• amifostine
• amphetamines (e.g., Dextroamphetamine, Lisdexamfetamine)
• angiotensin converting enzyme inhibitors (ACEIs; captopril, enalapril, ramipril)
• angiotensin II receptor blockers (ARBs; e.g., Candesartan, Irbesartan, Losartan)
• antacids (e.g., calcium carbonate, magnesium hydroxide)
• Azathioprine
• barbiturates (e.g., butalbital, pentobarbital, Phenobarbital)
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
• brimonidine
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Cyclosporine
• dexmethylphenidate
• diabetes medications (e.g., Canagliflozin, chlorpropamide, glipizide, Glyburide, insulin, Metformin,  Rosiglitazone)
• diazoxide
• Dipyridamole
• diuretics (water pills; e.g., Furosemide, Amiloride, Spironolactone, triamterene)
• drospirenone
• Duloxetine
• Eplerenone
• Everolimus
• gold salts
• grass pollen allergen extract
• Guanfacine
• Heparin
• iron dextran
• iron gluconate
• levodopa
• lithium
• low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
• medications that increase blood levels of potassium (e.g., potassium chloride, salt substitutes containing potassium)
• medications that lower blood pressure
• Methylphenidate
• nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., Indomethacin)
• Obinutuzumab
• Pentoxifylline
• phosphodiesterase 5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• Pregabalin
• sacubitril
• second generation anti-psychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
• Sirolimus
• sodium phosphates
• Tacrolimus
• Temsirolimus
• Tizanidine
• Tolvaptan
• Trimethoprim
• Yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Trandolapril. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Trandolapril.

Angioedema: Angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) may occur with trandolapril, although uncommonly. Angioedema may also affect the digestive system. If swelling of the face, tongue, or glottis occurs, or you experience unexpected abdominal pain that may be accompanied by nausea or vomiting, stop the medication at once and seek immediate medical attention. If you experience angioedema with trandolapril, you should not take any of the other ACE inhibitors, such as Enalapril, Lisinopril, or Quinapril.

People who have had angioedema caused by other substances may be at increased risk of angioedema while taking an ACE inhibitor such as trandolapril.

Blood disorders: In rare cases, a low white blood cell count has been reported by people taking Trandolapril. Your doctor may occasionally monitor your level of white blood cells by performing blood tests. Low white blood cell levels may increase your risk for infection. If you notice any signs of infection (e.g., fever, sore throat), contact your doctor as soon as possible.

Cough: People taking trandolapril may develop a dry, persistent cough that usually disappears only after stopping or lowering the trandolapril dose. Be sure to tell your doctor of any cough which does not seem to be related to a usual cause.

Dizziness/reduced alertness: Trandolapril can cause side effects such as dizziness, drowsiness, headache or fatigue that may reduce alertness, especially when you first start to take Trandolapril. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by Trandolapril.

Fluid and electrolyte balance: Increases in blood levels of potassium may occur as a result of taking trandolapril. This rarely causes problems, but your doctor will probably want to monitor your potassium levels regularly with blood tests. If you experience unexplained nausea, fatigue, muscle weakness, or tingling sensations, contact your doctor.

Kidney function: Certain people who take Trandolapril may experience changes in kidney function. Some people may be more likely to experience changes in kidney function (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills), aliskiren, or nonsteroidal anti-inflammatory drugs (NSAIDs), may further increase risk of kidney problems for those at risk for this problem. If you have kidney disease, discuss with your doctor how Trandolapril may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trandolapril, and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause Trandolapril to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Trandolapril may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trandolapril, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Trandolapril.

Trandolapril may also cause a decrease in liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Occasionally, blood pressure drops too low after taking trandolapril. This usually happens after the first or second dose or when the dose is increased. It is more likely to occur for those who take aliskiren, water pills, have a salt restricted diet, are on dialysis, or are experiencing diarrhea or vomiting. These individuals should be monitored closely by their doctor for the first weeks of treatment and whenever the dose of the medication is increased. To reduce the risk of dizziness, get up slowly from a lying down or sitting position. If low blood pressure causes you to faint or feel lightheaded, contact your doctor.

Excessive sweating and lack of fluid intake may lead to an excessive fall in blood pressure because of reduced fluid in your blood vessels. Vomiting or diarrhea may also lead to a fall in blood pressure. Consult your doctor if you feel your blood pressure is too low.

Pregnancy: ACE inhibitors such as trandolapril may cause severe harm or death to a developing baby if taken by the mother during pregnancy. Trandolapril should not be used during pregnancy. If you become pregnant while taking Trandolapril, contact your doctor immediately.

Breast-feeding: Trandolapril passes into breast milk. If you are a breast-feeding mother and are taking trandolapril, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Trandolapril have not been established for children.

Seniors: Seniors may have an increased risk of experiencing side effects when taking trandolapril due to reduced kidney function. Lower doses may be necessary to minimize side effects.

Trandolapril belongs to the class of medications called angiotensin converting enzyme (ACE) inhibitors. It is used to treat mild-to-moderate high blood pressure. It works by relaxing blood vessels, allowing the heart to pump more efficiently. It is also used after heart attacks to reduce the risk of another Heart Attack and prevent the onset or worsening of Congestive Heart Failure.

Trandolapril may be available under multiple brand names and/or in several different forms. Any specific brand name of Trandolapril may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Trandolapril may not be used for all of the conditions discussed here.

Your doctor may have suggested Trandolapril for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Trandolapril, speak to your doctor. Do not stop taking Trandolapril without consulting your doctor.

Do not give Trandolapril to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Trandolapril if their doctor has not prescribed it.