Jardiance (Empagliflozin) belongs to the class of medications called oral antihyperglycemic agents. It works in the kidneys to increase the amount of glucose removed from the body by the kidneys.

Jardiance (Empagliflozin) is used alone or in combination with other medications for people with Type 2 Diabetes to control their blood glucose. Jardiance (Empagliflozin) should be used as part of an overall diabetes management plan that includes a diet and exercise program.

Jardiance (Empagliflozin) is also used for people with type 2 diabetes who also have cardiovascular disease. It is used in addition to diet, exercise, and other medications to reduce the risk of dying from cardiac disease.

Jardiance (Empagliflozin) may be available under multiple brand names and/or in several different forms. Any specific brand name of Jardiance (Empagliflozin) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Jardiance (Empagliflozin) may not be used for all of the conditions discussed here.

Your doctor may have suggested Jardiance (Empagliflozin) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Jardiance (Empagliflozin), speak to your doctor. Do not stop taking Jardiance (Empagliflozin) without consulting your doctor.

Do not give Jardiance (Empagliflozin) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Jardiance (Empagliflozin) if their doctor has not prescribed it.

Do not give Jardiance (Empagliflozin) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Jardiance (Empagliflozin) if their doctor has not prescribed it.

How should I use Jardiance (Empagliflozin)?

The usual starting dose of Jardiance (Empagliflozin) is 10 mg taken by mouth once a day. Depending on how effectively it reduces your blood glucose, your doctor may increase the dose to 25 mg taken once a day.

Jardiance (Empagliflozin) may be taken at any time of the day, with or without food. The tablet must be swallowed whole. Do not cut or chew the tablets.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Jardiance (Empagliflozin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 12 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Jardiance (Empagliflozin) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Jardiance (Empagliflozin). If you are concerned about side effects, discuss the risks and benefits of Jardiance (Empagliflozin) with your doctor.

The following side effects have been reported by at least 1% of people taking Jardiance (Empagliflozin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• dizziness when rising from a sitting or lying position
• increased urination
• itching
• rash
• symptoms of yeast infection of the penis (e.g., red, swollen, itchy head of penis, unpleasant odour, discharge under foreskin, pain passing urine or during sexual activity)
• symptoms of vaginal yeast infection (e.g., itching, burning, soreness, whitish-grey discharge)
• unusual thirst

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• fainting
• Low Blood Pressure
• signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
• signs of infection that has spread from the urinary tract (e.g., Fever or chills, severe Diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour)
• symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)
• symptoms of a urinary tract infection (e.g., pain when urinating, urinating more often than usual, low back or flank pain)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• pain, redness, or swelling in and around the anus or genitals, especially if accompanied by fever, tiredness, or weakness
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of a serious skin reaction (e.g., skin rash; red skin; blistering of the lips, eyes, or mouth; skin peeling; fever; or joint pain)
• symptoms of diabetic ketoacidosis (DKA; e.g., difficulty breathing, extreme thirst, vomiting, nausea, loss of appetite, stomach pain, confusion, unusual tiredness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Jardiance (Empagliflozin).

10 mg
Each pale yellow, round, biconvex and bevelled-edged, film-coated tablet, debossed with "S10" on one side and the Boehringer Ingelheim company symbol on the other side, contains 10 mg of Jardiance (Empagliflozin). Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, macrogol, microcrystalline cellulose, titanium dioxide, talc, and yellow ferric oxide.

25 mg
Each pale yellow, oval, biconvex, film-coated tablet, debossed with "S25" on one side and the Boehringer Ingelheim company symbol on the other side, contains 25 mg of Jardiance (Empagliflozin). Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, macrogol, microcrystalline cellulose, titanium dioxide, talc, and yellow ferric oxide.

Do not take Jardiance (Empagliflozin) if you:

• are allergic to Jardiance (Empagliflozin) or any ingredients of the medication
• have severely decreased kidney function or end-stage Kidney Disease, or are on dialysis
• have type I diabetes

There may be an interaction between Jardiance (Empagliflozin) and any of the following:

• acetylsalicylic acid (Asa)
• androgens (e.g., testosterone)
• angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
• atypical antipsychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
• other diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Rosiglitazone)
• Disopyramide
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• Duloxetine
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Everolimus
• Glucagon
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
• Lanreotide
• levodopa
• mifepristone
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
• Niacin
• Octreotide
• oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
• Pasireotide
• pentamidine
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• somatostatin
• sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
• Tacrolimus
• Teriflunomide
• Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Jardiance (Empagliflozin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.