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Selegiline belongs to the class of medications called monoamine oxidase inhibitors (M. O.
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Selegiline belongs to the class of medications called monoamine oxidase inhibitors (M.O.S.. It is used to treat Parkinson's Disease. It acts on the nervous system to increase the levels of a chemical called dopamine. Low dopamine levels in the brain are responsible for many of the symptoms of Parkinson's disease, so Selegiline works by rebalancing the levels of dopamine.
Selegiline may be taken alone or in combination with levodopa to treat the symptoms of Parkinson's disease.
Selegiline may be available under multiple brand names and/or in several different forms. Any specific brand name of Selegiline may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Selegiline may not be used for all of the conditions discussed here.
Your doctor may have suggested Selegiline for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Selegiline, speak to your doctor. Do not stop taking Selegiline without consulting your doctor.
Do not give Selegiline to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Selegiline if their doctor has not prescribed it.
The recommended adult dose of selegiline is 5 mg taken twice a day with breakfast and lunch.
Do not take Selegiline later in the day because it may interfere with sleep. Do not use doses higher than this, as there is increased risk of side effects at higher doses and no evidence that there is any greater effect of the medication.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Selegiline exactly as prescribed by your doctor. If you miss a dose of Selegiline, take it as soon as possible. If you do not remember your dose until late afternoon or evening, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Selegiline at room temperature, protect it from light, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Selegiline. If you are concerned about side effects, discuss the risks and benefits of Selegiline with your doctor.
The following side effects have been reported by at least 1% of people taking Selegiline. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Get medical help immediately if any of the following signs of extremely high blood pressure occur (caused by the use of Selegiline with certain foods or medications):
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Selegiline.
Selegiline by Pharmel is no longer being manufactured for sale in Canada. For brands that may still be available, search under selegiline. This article is being kept available for reference purposes only. If you are using Selegiline, speak with your doctor or pharmacist for information about your treatment options.
Do not take selegiline if you:
There may be an interaction between selegiline and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than the ones listed above may interact with Selegiline. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Selegiline.
Antidepressant medication: Severe reactions are possible when selegiline is combined with tricyclic antidepressants or serotonin reuptake inhibitors, medications used to treat depression. The combination of selegiline and antidepressants from these groups must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, and changes in mental state including delirium and agitation. Coma and death are also possible.
If you take any of these medications or have taken antidepressants recently, discuss with your doctor how Selegiline may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Selegiline, and whether any special monitoring is needed.
Headache: If you experiencing a severe headache or other unusual symptoms while taking selegiline, report them to a doctor immediately.
Levodopa: Some people who take selegiline may experience a worsening of levodopa-associated side effects, such as unusual movements of the body. Report these effects to your doctor as soon as possible. Your doctor may help with these effects by reducing the dose of levodopa.
Liver function: People taking selegiline may have changes in liver function that produce abnormal liver test results. Your doctor may recommend regular liver tests while you are taking Selegiline.
Maximum dose: Do not exceed the recommended daily dose of 10 mg of selegiline.
Pregnancy: Selegiline should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Selegiline, contact your doctor immediately.
Breast-feeding: It is not known if selegiline passes into breast milk. If you are a breast-feeding mother and are taking Selegiline, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Selegiline have not been established for children.
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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