If you or someone in your family have been prescribed Sertraline (Zoloft) and have questions about its interaction with alcohol and risk of liver damage, keep reading the article.

What is Zoloft?

Zoloft is a prescription medication that is used in the treatment of: 

  • Panic attacks
  • Obsessive-compulsive disorder (a condition in which irritating thoughts do not go away and there is the need to perform specific actions over and over)
  • Depression
  • Social anxiety (extreme fear of performing or interacting with others that interferes with daily life)
  • Post-traumatic stress disorder (a condition where disruptive symptoms like nightmares or severe anxiety develop after having a frightening experience). 

Zoloft helps with bloating, mood swings, breast tenderness and irritability in your period

Zoloft can also relieve symptoms of premenstrual dysphoric disorder, which causes symptoms like bloating, mood swings, breast tenderness, and irritability before your period. The active ingredient of Zoloft is sertraline. It belongs to a class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs). 

What is Sertraline?

Sertraline acts by increasing the amount of serotonin (the happy hormone or chemical in the brain). Increased serotonin levels in the brain help maintain mental balance, improve mood, and improve symptoms of depression and anxiety. 

What happens if you drink alcohol with sertraline?

When you have been prescribed sertraline, your healthcare professional will advise you not to drink alcohol. 

Moreover, if you have depression, you should avoid alcohol as it depresses your central nervous system and may worsen your symptoms. So, it is best to avoid consuming alcohol while on treatment with sertraline. 

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What side effects can you expect if taking alcohol while on Zoloft sertraline?

Health Canada recommends avoiding alcohol while on treatment with Zoloft. Alcohol consumption can amplify the side effects of sertraline. Symptoms include difficulty in concentration, dizziness, and drowsiness.  

If you have depression, your symptoms may worsen if you consume alcohol, especially when you drink significant amounts. 

Sertraline and alcohol liver damage: Is alcohol safe?

In general, sertraline isn’t known to worsen or increase the risk of alcohol-related liver damage. However, it’s clear that drinking excessive alcohol is harmful to the liver in itself. People with depression and anxiety have a higher chance of suffering from substance use disorder, where you might drink too much alcohol in an unhealthy way. This is another reason to avoid alcohol when taking sertraline. 

Rarely, sertraline by itself can also cause acute liver injury. . 

Sertraline for alcohol withdrawal

Research shows that sertraline is helpful for reducing alcohol use in people with mood disorders. 

Sertraline 100mg and alcohol

Health Canada recommends avoiding alcohol while on treatment with Zoloft. Alcohol consumption can amplify the side effects of sertraline. Symptoms include difficulty in concentration, dizziness, and drowsiness. 

If you have depression, your symptoms may worsen if you consume alcohol, especially when you drink excessively. Mood disorders can also make it more likely that you abuse alcohol and drink in harmful amounts. 

150mg sertraline and alcohol

The same side effects apply to that of taking 100mg of sertraline and consuming alcohol.

Sertraline and alcohol: What do reviews say?

Sertraline has 7.2 out of 10 on drugs.com. None of the users mentioned taking alcohol with the medication. 

Can sertraline and alcohol cause death?

It would be best if you did not drink while taking sertraline, as it is not recommended by doctors and health agencies. It’s unknown whether the combination of alcohol and sertraline have caused deaths. However, the additive side effects of alcohol and sertraline could be very serious. For example, drowsiness could lead to bad consequences like a fatal accident or choking on vomit. 

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